[1]丁永芬,程玲,赖娟,等.补肾活血方治疗肾虚血瘀型多囊卵巢综合征80例[J].西部中医药,2019,32(04):97-99.
　DING Yongfen,CHENG Ling,LAI Juan,et al.Invigorating-kidney Activating-blood Prescription in Treating 80 Patients of PCOS of Kidney-deficiency Blood-stasis Pattern[J].Western Journal of Traditional Chinese Medicine,2019,32(04):97-99.
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补肾活血方治疗肾虚血瘀型多囊卵巢综合征80例
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
32
期数:
2019年04期
页码:
97-99
栏目:
出版日期:
2019-04-15

文章信息/Info

Title:
Invigorating-kidney Activating-blood Prescription in Treating 80 Patients of PCOS of Kidney-deficiency Blood-stasis Pattern
文章编号:
1004-6852(2019)04-0097-03
作者:
丁永芬，程玲，赖娟，徐先敏
中国中医科学院望京医院，北京 100102
Author(s):
DING Yongfen, CHENG Ling, LAI Juan, XU Xianmin
Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 100102, China
关键词:
多囊卵巢综合征; 补肾活血方; 性激素
Keywords:
PCOS; invigorating-kidney activating-blood prescription;  sex hormone
分类号:
R711.75
文献标志码:
B
摘要:
目的：观察补肾活血方治疗肾虚血瘀型多囊卵巢综合征(PCOS)的临床疗效。方法：将157例患者随机分为2组。观察组80例，服用补肾活血方，1剂/d，每日一次；对照组77例，予炔雌醇环丙孕酮(达英35)口服1片/次，1次/d，2组均以治疗3个月为1疗程，共治疗2个疗程，疗程结束3个月后统计临床疗效、妊娠率与基础体温双相率，检测血清睾酮(T)、黄体生成素(LH)、促卵泡素(FSH)、雌二醇(E2)等指标。结果：总有效率观察组为90.0%，对照组为80.5%，2组比较差异无统计学意义(P＞0.05)。基础体温双相率观察组为30.0%，对照组为13.0%，2组比较差异有统计学意义(P＜0.05)。妊娠率观察组为20.0%，对照组为7.8%，2组比较差异有统计学意义(P＜0.05)。对照组中1例治疗1个疗程后丙氨酸转移酶升高，停药后经消化科治疗3个月后恢复正常。观察组未见异常。观察组治疗后FSH、LH、T治疗后明显下降，差异有统计学意义(P＜0.05)。对照组治疗后FSH水平无明显变化，差异无统计学意义(P＞0.05)，LH、E2、T治疗后明显下降，差异有统计学意义(P＜0.05)。结论：补肾活血方治疗PCOS临床疗效确切。
Abstract:
Objective: To observe clinical effects of invigorating-kidney activating-blood prescription in the treatment for polycystic ovarian syndrome (PCOS) of kidney-deficiency blood-stasis pattern. Methods: All 157 patients were randomized into two groups, 80 cases of the observation group took invigorating-kidney activating-blood prescription orally, one dose each day, once each day; and 77 cases of the control group were given ethinylestradiol and cyproterone acetate tablets orally, one pill each time once each day, three months were one course, and both groups were treated for two courses, the indexes of estradiol(E2), follicle-stimulating hormone(FSH), luteinizing hormone(LH) and testosterone(T) were detected, clinical effects, pregnancy rate and basal body temperature two-phase rates were counted in three months after the course ended. Results: Total effective rate of the observation group was 90.0%, higher than 80.5% of the control group, and the difference had no statistical meaning (P＞0.05). Two-phase rate of basal body temperature of the observation group was 30.0%, higher than 13.0% of the control group, and the difference had statistical meaning (P＜0.05). The pregnancy rate of the observation group was 20.0%, higher than 7.8% of the control group, and the difference showed statistical meaning(P＜0.05). After one course, alanine transferase (ALT) of one case in the control group rose, and it restored to normal after withdrawl when they were treated for three months in gastrointestinal department. No abnormality was found in the observation group. The levels of FSH ,LH and T lowered notably in the observation groups after treating, and the difference had no statistical meaning(P＜0.05). No obvious change had been found in the level of FSH in the control group after treating, and the difference had no statistical meaning (P＞0.05), the levels of LH, E2 and T decreased notably after treating, and the difference had been found (P＜0.05). The difference had no statistical meaning in the comparisons of these indexes between both groups after treating (P＞0.05). Conclusion: Invigorating-kidney activating-blood prescription could gain definite effects in the treatment for PCOS of kidney-deficiency blood-stasis pattern.

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备注/Memo

备注/Memo:
收稿日期：2018-11-01 *基金项目：中国中医科学院望京医院院级课题(编号wj2011-2)。 作者简介：丁永芬(1970—)，女，博士学位，副主任医师。研究方向：妇科内分泌疾病的诊治。
更新日期/Last Update: 2019-04-15