[1]刘华,崔秀卿,邢金梅,等.银杏达莫联合丁苯酞及瑞替普酶治疗急性脑梗死临床观察[J].西部中医药,2020,33(S1):90-91.
 LIU Hua,CUI Xiuqing,XING Jinmei,et al.Clinical Observation on Ginkgo Leaf Extract and Dipyridamole Injection,Butylphthalide and Reteplase in Treating Acute Cerebral Infarction[J].Western Journal of Traditional Chinese Medicine,2020,33(S1):90-91.
点击复制

银杏达莫联合丁苯酞及瑞替普酶治疗急性脑梗死临床观察()
分享到:

《西部中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
33
期数:
2020年S1
页码:
90-91
栏目:
出版日期:
2021-06-30

文章信息/Info

Title:
Clinical Observation on Ginkgo Leaf Extract and Dipyridamole Injection,Butylphthalide and Reteplase in Treating Acute Cerebral Infarction
作者:
刘华1 崔秀卿2 邢金梅2 时岩2
1 保定市安国市医院, 河北保定 071200;2 保定市第二医院
Author(s):
LIU Hua1 CUI Xiuqing2 XING Jinmei2 SHI Yan2
1 Anguo City Hospital, Baoding 071200, China; 2 Baoding City the Second Hospital
关键词:
急性脑梗死 1 型纤维蛋白溶解酶原激活抑制剂 超氧化物歧化酶血浆组织纤维蛋白溶解酶原激活剂 神经功能 生活质量 银杏达莫 丁苯酞 瑞替普酶
Keywords:
acute cerebralinfarction PAI-1SODt-PA neurological functionquality of life ginkgo leaf extract and dipyridamole injection butylphthalide reteplase
摘要:
目的: 观察银杏达莫联合丁苯酞及瑞替普酶治疗急性脑梗死的临床疗效。方法:将急性脑梗死患者 120 例采用随机数字表法分为两组各60例, 对照组采用丁苯酞联合瑞替普酶治疗,治疗组在对照组基础上加用银杏达莫治疗,7天为1个疗程,两个疗程后观察两组患者临床疗效,检测治疗前后两组患者血清C反应蛋白(C-reaction protein, CRP)、 肿瘤坏死因子α(tumor necrosis factor α, TNF-α)、 白细胞介素 1β(interleukin-1β, IL-1β)、 超氧化物歧化酶(superoxide dismutase, SOD)、 丙二醛(malonaldehyde,MDA)、 一氧化氮(nitric oxide, NO), 血浆组织纤维蛋白溶解酶原激活剂(tissue-type plaminogen activator, t-PA)、 1型纤维蛋白溶解酶原激活抑制剂(plasminogen activator inhibitor-1, PAI-1)水平, 评估两组患者神经功能缺损评分 (national institute of health strolce scale,NIHSS)及日常生活能力评分(activities of daily living,ADL)。结果: 总有效率治疗组为 91.7%(55/60), 优于对照组的 83.3%(50/60), 差异有统计学意义(P<0.05)。两组治疗后 CRP、 TNF-α、 IL-1β、 MDA、 PAI-1 及 NIHSS 评分较治疗前降低, SOD、 NO、 t-PA 及 ADL 评分较治疗前升高, 治疗组各项指标改善程度优于对照组, 差异均有统计学意义 (P<0.05)。 结论: 银杏达莫联合丁苯酞及瑞替普酶能减轻急性脑梗死患者炎症反应, 调节血浆纤维蛋白溶解系统功能, 清除体内氧自由基及提高抗氧化酶活性, 能恢复患者的神经功能, 提高其日常生活能力, 改善患者生活质量, 效果优于丁苯酞联合瑞替普酶。
Abstract:
Objective: To observe clinical effects of ginkgo leaf extract and dipyridamole injection,butylphthalide and reteplase in treating acute cerebral infarction (ACI). Methods: All 120 patients were allocated to two groups according to random number table method, 60 cases each group, the control group were treated by butylphthalide and reteplase, the treatment group by ginkgo leaf extract and dipyridamole injection based on the therapty the control group accepted, seven days were one course, to observe clinical effects in both groups after two courses, to detect the levels of CRP, TNF-α, IL-1β, SOD, MDA, NO, t-PA and PAI-1 before and after treating between both groups, to assess NIHSS scores and ADL scores between both groups. Results: Total effective rate of the treatment group was 91.7%(55/60), superior to 83.3%(50/60) of the control group, and the difference hadstatistical meaning (P<0.05). The levels of CRP, TNF-α, IL-1β, MDA, PAI-1 and NIHSS scores of both groups after treating reduced than before treating, the levels of SOD, NO and t-PA and ADL scores rose compared with these before treating, and the improvements of different indexes of the treatment group were superior to these of the control group, and the difference had statistical meaning (P <0.05). Conclusion: Ginkgo leaf extract and dipyridamole injection, butylphthalide and reteplase could relieve inflammatory reaction in ACI patients, regulate the function of plasma fibrinolysis system, eliminate oxygen free radicals in vivo and enhance the activity of antioxidant enzyme, help the recovery of neurological function, lift ADL, improve quality of life in patients, and its effects superior to these of butylphthalide and reteplase.

参考文献/References:

[1]中华医学会神经病学分会脑血管病学组缺血性脑卒中二级预防指南撰写组.中国缺血性脑卒中和短暂性脑缺血发作二级预防指南[J]中华神经科杂志,2010,43(2):154-160.
[2]许锦奋.川芎嗪、银杏达莫注射液治疗脑梗塞急性期不同证型的临床研究[D].广州:广州中医药大学,2011.
[3]中华医学会神经病学分会.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,(4):246-257.
[4]国家中医药管理局.中医病症诊断疗效标准[S].南京:南京大学出版社,1994:24.
[5]李丽.丁苯酞联合法舒地尔治疗急性脑梗死的疗效及对血浆超敏C反应蛋白及血黏度的影响[J].中国实用神经疾病杂志,2016,19(23):65-67.
[6]张磊(整理).美国国立卫生研究院卒中量表[J].中华神经外科杂志,2014,30(1):79.
[7]付广荣,李根玉.丁苯酞对急性脑梗死患者NT-proBNP水平和血清炎症因子的影响[J].药物评价研究,2017,40(4):513-516.
[8]日常生活能力量表(ADL)简介[J].临床荟萃,2009,24(14):1216.
[9]陈清棠.脑卒中患者临床神经功能缺损程度评分标准(1995)[J].中华神经科杂志,1996,29(6):381-383.
[10]武玉举,成连江.两种方案治疗急性缺血性脑血管病的临床分析[J].中国现代药物应用,2016,10(16):195-196.
[11] 曹开端.银杏达莫注射液治疗急性脑梗死的临床研究[J].药品评价,2017,14(8):36-38.
[12] 刘浪.银杏达莫注射液对急性脑梗死颈动脉相关指标的影响[J].西南国防医药,2017,27(5):462-465.
[13] 李撵萍.银杏达莫注射液治疗急性脑梗塞患者的临床观察[J].中医临床研究,2016,8(26):65-66,67.
[14] 任德全,颉飞鸿,崔建平,等.银杏达莫注射液治疗急性脑梗死的Meta分析[J].数理医药学杂志,2016,29(10):1518-1520.
[15]彭俊阳.丁苯酞注射液对急性脑梗死患者血清中VEGF_bFGF水平的影响[D].长春:吉林大学,2011.
[16]Song-Jie Liao,Jian-Wen Lin,Zhong Pei,Chun-Ling Liu,Jin-Sheng Zeng,Ru-Xun Huang. Enhanced angiogenesis with dl -3n-butylphthalide treatment after focal cerebral ischemia in RHRSP[J]. Brain Research,2009,1289.
[17] 陈清清,梁彩红,丁一.局部灌注瑞替普酶与阿替普酶治疗肺动脉栓塞的效果比较[J].中国基层医药,2017,24(12):1785-1789.
[18] 符布清,赵春,沈建江,等.急性脑梗死中医证型与T-SOD、NO、MDA的相关性分析[J].中西医结合心脑血管病杂志,2016,14(20):2348-2349.
[19] 韩晶,王胜文,杨柏新,等.动脉留置导管连续给药对脑梗死患者血清IL-1β、hs-CRP、TNF-α水平的影响[J].中国老年学杂志,2014,(20):5644-5645.
[20] 卢波,韩莉,吕志昆,等.急性脑梗死患者血清炎性因子、t-PA、PAI-1变化规律及其意义[J].疑难病杂志,2015,14(9):906-909.

相似文献/References:

[1]曹骅,张振昶.银杏二萜内酯葡胺注射液治疗急性脑梗死疗效观察[J].西部中医药,2019,32(03):74.
 CAO Hua,ZHANG Zhenchang.Clinical Observation on Treating Acute Cerebral Infarction with Ginkgo Biloba Diterpene Lactone Meglumine Injection[J].Western Journal of Traditional Chinese Medicine,2019,32(S1):74.
[2]蓝雪花,陈嘉汇,覃丽容,等.中医护理在急性脑梗死患者中的应用[J].西部中医药,2019,32(08):126.
 LAN Xuehua,CHEN Jiahui,QIN Lirong,et al.The Application of TCM Nursing to the Patients Suffering Acute Cerebral Infarction[J].Western Journal of Traditional Chinese Medicine,2019,32(S1):126.
[3]杨光,岳扬,才蕊.银杏叶提取物注射液联合持续正压通气治疗急性脑梗死合并OSAHS 43例[J].西部中医药,2020,33(04):99.[doi:10.12174/j.issn.1004-6852.2020.04.30]
 YANG Guang,YUE Yang,CAI Rui.Ginkgo Biloba Leaf Extract Injection Joined with Continuous Positive Airway Pressure in Treating 43 Cases of Acute Cerebral Infarction Complicated with OSAHS[J].Western Journal of Traditional Chinese Medicine,2020,33(S1):99.[doi:10.12174/j.issn.1004-6852.2020.04.30]

备注/Memo

备注/Memo:
收稿日期: 2019-05-14 * 基金项目: 保定市科技计划项目(18ZF016)。 作者简介: 刘华(1984—), 女, 主治医师。研究方向: 脑血管病的中西医结合防治。
更新日期/Last Update: 2020-09-30