[1]曾寒泊,麻春杰△,魏玉霞,等.胃和冲剂Ⅱ号对慢性萎缩性胃炎寒热错杂证患者胃黏膜PTEN和ERK-2蛋白表达的影响[J].西部中医药,2019,32(07):16-19.
 ZENG Hanbo,MA Chunjie,WEI Yuxia,et al.Effects of WeiHe Granules No.Ⅱ on the Expressions of Gastric Mucosa PTEN and ERK-2 Protein of the Patients with CAG of Intermingled Heat and Cold Pattern[J].Western Journal of Traditional Chinese Medicine,2019,32(07):16-19.
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胃和冲剂Ⅱ号对慢性萎缩性胃炎寒热错杂证患者胃黏膜PTEN和ERK-2蛋白表达的影响
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《西部中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
32
期数:
2019年07期
页码:
16-19
栏目:
方药·药理研究
出版日期:
2019-07-15

文章信息/Info

Title:
Effects of WeiHe Granules No.Ⅱ on the Expressions of Gastric Mucosa PTEN and ERK-2 Protein of the Patients with CAG of Intermingled Heat and Cold Pattern
文章编号:
1004-6852(2019)07-0016-04
作者:
曾寒泊1麻春杰1△魏玉霞2胡刚2李翰1郝蔷薇1任存霞1白雅文1牛仁秀1
1 内蒙古医科大学中医学院,内蒙古 呼和浩特 010110; 2 内蒙古自治区中医医院
Author(s):
ZENG Hanbo1 MA Chunjie1△ WEI Yuxia2 HU Gang2 LI Han1 HAO Qiangwei1REN Cunxia1 BAI Yawen1 NIU Renxiu1
1 TCM College, Inner Mongolia Medical University, Hohhot 010110, China; 2 Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine
关键词:
慢性萎缩性胃炎PTENERK-2胃和冲剂Ⅱ号
Keywords:
CAG PTEN ERK-2 WeiHe granules no.Ⅱ
分类号:
R243
文献标志码:
A
摘要:
目的:探讨胃和冲剂Ⅱ号对慢性萎缩性胃炎(CAG)寒热错杂证患者胃黏膜PTEN和ERK-2蛋白表达的影响。方法:将CAG患者60例随机分为治疗组和对照组各30例,治疗组口服胃和冲剂Ⅱ号(2次/d,10 g/次),对照组口服胃复春片(3次/d,4片/次),2组均连续治疗12周。采用免疫组化法检测治疗前后经胃镜所取患者胃黏膜组织中PTEN和ERK-2,比较2组患者治疗前后PTEN和ERK-2蛋白表达的差异。结果:治疗后2组患者PTEN蛋白表达均升高(P<0.05),ERK-2蛋白表达均降低(P<0.05),2组组间比较差异无统计学意义(P>0.05)。结论:胃和冲剂Ⅱ号可能通过提高PTEN表达,抑制ERK2表达改善CAG寒热错杂证患者的胃黏膜病理状态,效果与胃复春片相当。
Abstract:
Objective: To discuss the effects of WeiHe granules no.Ⅱ on the expression of gastric mucosa PTEN and ERK-2 protein of the patients with chronic atrophic gastritis (CAG) of intermingled heat and cold pattern. Methods: Sixty CAG patients were randomized into the treatment group and the control group, 30 cases each group, the treatment group took WeiHe granules no.Ⅱ, twice each day, 10g each time, and the control group Weifuchun tablets, three times each day, four tablets each time, both groups were treated for 12 weeks consecutively. Pathological tissue of gastric mucosa were collected before and after treating using gastroscope, immunohistochemical method was used to detect PTEN and ERK-2, and compare the difference between their expressions before and after treating in both groups. Results: After treating PTEN protein expressions of both groups raised(P<0.05), ERK-2 protein expressions lowered(P<0.05), no obvious difference could be found in the expressions of PTEN and ERK-2 between both groups (P>0.05). Conclusion: WeiHe granules no.Ⅱ could improve pathological state of gastric mucosa in the patients of CAG of intermingled heat and cold pattern which might be realized by raising the expressions of PTEN and inhibiting the expression of ERK-2, and its effects are equivalent to Weifuchun tablets.

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备注/Memo

备注/Memo:
收稿日期:2018-05-21*基金项目:内蒙古自治区2013年应用技术研究与开发资金项目(编号kjt13sf17);内蒙古自治区2013年医疗卫生科研计划项目(编号201303034)。作者简介:曾寒泊(1989—),男,硕士学位。研究方向:脾胃病的中医诊治。△通讯作者:麻春杰(1965—),女,博士学位,教授。研究方向:消化系统疾病的诊治。
更新日期/Last Update: 2019-07-15