[1]沈照峰,朱磊,刘亚军,等.基于德尔菲法的溃疡性结肠炎患者相关危险因素调查分析[J].西部中医药,2020,33(04):82-86.[doi:10.12174/j.issn.1004-6852.2020.04.25]
　SHEN Zhaofeng,ZHU Lei,LIU Yajun,et al.An Investigation into the Related Risk Factors of UC Patients Based on Delphi Method[J].Western Journal of Traditional Chinese Medicine,2020,33(04):82-86.[doi:10.12174/j.issn.1004-6852.2020.04.25]
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基于德尔菲法的溃疡性结肠炎患者相关危险因素调查分析
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年04期
页码:
82-86
栏目:
出版日期:
2020-04-15

文章信息/Info

Title:
An Investigation into the Related Risk Factors of UC Patients Based on Delphi Method
文章编号:
1004-6852(2020)04-0082-05
作者:
沈照峰，朱磊，刘亚军，周青
江苏省中医院/南京中医药大学附属医院，江苏 南京 210029
Author(s):
SHEN Zhaofeng, ZHU Lei, LIU Yajun, ZHOU Qing△
Jiangsu Province Hospital of Chinese Medicine / Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China
关键词:
结肠炎; 溃疡性; 病例对照研究; 危险因素; 德尔菲法
Keywords:
colitis;  ulcerative;  case control study;  risk factors;  delphi method
分类号:
R516.1
DOI:
10.12174/j.issn.1004-6852.2020.04.25
文献标志码:
A
摘要:
目的：探讨溃疡性结肠炎(ulcerative colitis，UC)患者相关危险因素，丰富我国UC流行病学数据库。方法：运用德尔菲专家咨询法构建《溃疡性结肠炎患者流行病学调查问卷》，按照病例对照研究的设计思路，对来源于全国12家大型中医院的253例UC患者及同期对照进行回顾性的临床流行病学调查，通过对调查数据进行提取，应用SPSS 22.0软件先进行单因素分析，筛选出可能的危险因素，再将其纳入多因素logistic模型进行系统分析，并计算各因素OR及95%可信区间。结果：1)经过2轮的专家评议，专家积极系数为88.9%，按指标权重排序，共评出89个一致性较高的UC危险因素，形成相对权威可信的调查表；2)临床流行病学调查共纳入了253例UC病例和253例对照者，单因素分析提示有15个可能的影响因素，分别为职业性质、性格情志、宠物牲畜、家庭饮水、吸烟、饮食结构、冰箱食物、饮酒、甜食、油炸腌渍食品、辛辣刺激食物、蔬菜水果、生命早期感染、大量使用抗生素、NSAID类药物和家族史；而多元回归分析显示，性格内向、饮食结构以肉食为主、经常吃油炸腌制的食物、经常吃冰箱食物、生命早期感染史、有感染性腹泻等家族史是UC发病的危险因素(OR＞1，P＜0.05)，而经常吃蔬菜水果、吸烟是UC的保护因素(OR＜1，P＜0.05)。结论：本次调查发现，导致溃疡性结肠炎发病的主要因素包括性格情志、饮食结构、油炸腌渍食品摄入、蔬菜水果摄入、冰箱食物摄入、吸烟史、生命早期感染史、感染性腹泻等家族史，可针对上述危险因素和保护因素制定合理的健康教育和干预措施，以期降低疾病的发病率和患病率。
Abstract:
Objective: To explore the risk factors of the patients with ulcerative colitis (UC), and enrich the database of UC epidemiology. Methods: Delphi method was used to construct ″epidemiological questionnaire of UC patients″, 253 UC patients from 12 large TCM hospitals were investigated and a retrospective clinical epidemiologi-cal survey in the same period was performed according to the design ideas of case control study, SPSS 22.0 software was applied to perform single factor analysis and screen the potential risk factors through extracting the survey data, the potiential risk factors were systematically analyzed after included into multivariate logistic model, to calculate OR and 95% confidence interval of different factors. Results: 1) After two rounds of expert review, expert positive coefficient was 88.9%, according to the weight of the indexes, there were 89 UC risk factors, and they formed the relatively authoritative and credible questionnaire; 2) Clinical epidemiological investigation included 253 UC patients and 253 controls, single factor analysis suggested that there were 15 potential influencing factors, which contained professional nature, character and emotion, pet and livestock, drinking water, smoking, dietary structure, refrigerator food, drinking, sweet food, fried and pickled food, vegetables and fruits, early life infection, extensive use of antibiotics, NSAID drugs and family history; and multiple regression analysis showed that introverted personality, carnivorous mainly, often eating fried and pickled food, often eating refrigerator food, early life infection, family history of infectious diarrhea are the risk factors of UC attacking (OR＞1, P＜0.05), and often eating fruit and vegetables, smoking are the protective factors of UC (OR<1, P＜0.05). Conclusion: The main factors of inducing UC contain character and emotion, dietary structure, intake of fried and pickled food, vegetables and fruits and refrigerator food, smoking history, early life infection, family history of infectious diarrhea in the study, rational health education and intervention measures are established aiming at the above risk factors and protective factors, in an attempt to reduce the morbidity rate and the prevalence rate of the disease.

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备注/Memo

备注/Memo:
收稿日期：2019-06-11*基金项目：国家中医药管理局行业专项（201407001）；江苏省中医院创新发展基金（Y2019CX18）。作者简介：沈照峰(1989—)，男，硕士学位。研究方向：临床研究方法学、流行病学与卫生统计学研究。△通讯作者：周青(1981—)，男，博士学位，副主任中医师。研究方向：中西医结合临床研究。
更新日期/Last Update: 2020-04-15