[1]杨光,岳扬,才蕊.银杏叶提取物注射液联合持续正压通气治疗急性脑梗死合并OSAHS 43例[J].西部中医药,2020,33(04):99-102.[doi:10.12174/j.issn.1004-6852.2020.04.30]
　YANG Guang,YUE Yang,CAI Rui.Ginkgo Biloba Leaf Extract Injection Joined with Continuous Positive Airway Pressure in Treating 43 Cases of Acute Cerebral Infarction Complicated with OSAHS[J].Western Journal of Traditional Chinese Medicine,2020,33(04):99-102.[doi:10.12174/j.issn.1004-6852.2020.04.30]
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银杏叶提取物注射液联合持续正压通气治疗急性脑梗死合并OSAHS 43例
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年04期
页码:
99-102
栏目:
出版日期:
2020-04-15

文章信息/Info

Title:
Ginkgo Biloba Leaf Extract Injection Joined with Continuous Positive Airway Pressure in Treating 43 Cases of Acute Cerebral Infarction Complicated with OSAHS
文章编号:
1004-6852(2020)04-0099-04
作者:
杨光，岳扬，才蕊
1 唐山市协和医院，河北 唐山 063001； 2 唐山市丰南区医院
Author(s):
YANG Guang1, YUE Yang1, CAI Rui2
1 Tangshan Union Medical College Hospital, Tangshan 063001, China; 2 Fengnan District Hospital
关键词:
急性脑梗死; 阻塞性睡眠呼吸暂停综合征; 银杏叶提取物; 持续正压通气; C反应蛋白; 同型半胱氨酸; 基质金属蛋白酶9; 脑血流动力学
Keywords:
acute cerebral infarction;  OSAHS;  ginkgo biloba leaf extract;  continuous positive airway pressure;  CRP;  Hcy;  MMP-9;  cerebral hemodynamics
分类号:
R255.2
DOI:
10.12174/j.issn.1004-6852.2020.04.30
文献标志码:
B
摘要:
目的：观察银杏叶提取物注射液联合持续正压通气治疗急性脑梗死合并阻塞性睡眠呼吸暂停综合征(OSAHS)患者的临床疗效及对C反应蛋白(C-reactive protein，CRP)、同型半胱氨酸(Homocysteine，Hcy)、基质金属蛋白酶9（matrix metalloproteinases-9，MMP-9）和脑血流动力学的影响。方法：将84例急性脑梗死合并OSAHS患者按照随机数字表法分为观察组(43例)与对照组(41例)。观察组采用持续正压通气联合银杏叶提取物注射液治疗，对照组仅采用持续正压通气治疗。两组疗程均为4周。比较两组患者临床疗效，治疗前后神经功能缺损评分(National Institutes of Health Stroke Scale，NIHSS)、CRP、Hcy、MMP-9及脑血流动力学水平变化。结果：总有效率观察组为93.02%(40/43)，对照组为68.29%(28/41)，两组比较差异有统计学意义(P＜0.05)。NIHSS评分治疗前两组比较，差异无统计学意义(P＞0.05)；治疗后NIHSS评分两组均明显降低，差异有统计学意义(P＜0.05)；治疗后观察组低于对照组，差异有统计学意义(P＜0.05)。双侧大脑中动脉平均流速(Vm)和峰流速(Vp)治疗前两组比较，差异无统计学意义(P＞0.05)；两组治疗后均明显升高，差异有统计学意义(P＜0.05)；治疗后观察组高于对照组，差异有统计学意义(P＜0.05)。血清CRP、Hcy和MMP-9水平治疗前两组比较，差异无统计学意义(P＞0.05)；观察组治疗后明显降低，差异有统计学意义(P＜0.05)；对照组治疗后无明显变化，差异无统计学意义(P＞0.05)；治疗后两组比较，差异有统计学意义(P＜0.05)。结论：银杏叶提取物注射液联合持续正压通气治疗急性脑梗死合并OSAHS患者疗效显著，且可降低CRP、Hcy和MMP-9水平，改善脑血流动力学。
Abstract:
Objective: To observe clinical effects of ginkgo biloba leaf extract injection and continuous positive airway pressure in the treatment of acute cerebral infarction complicated with obstructive sleep apnea hypopnea syndrome (OSAHS), and their influence on CRP, Hcy, MMP-9 and cerebral hemodynamics. Methods: All 84 patients were allocated to the observation group (n=43) and the control group (n=41) according to random number table method. The observation group were treated by ginkgo biloba leaf extract injection and continuous positive airway pressure, the control group adopted continuous positive airway pressure. The course was four weeks. To compare therapeutic effects between both groups, NIHSS scores, CRP, Hcy, MMP-9 and cerebral hemodynamics before and after treating. Results: Total effective rate of the observation group was 93.02% (40/43), higher than 68.29% (28/41) of the control group, and the difference had statistical meaning (P＜0.05). The difference had no statistical meaning in NIHSS scores between both groups before treating (P＞0.05); after treating, NIHSS scores reduced in both groups obviously, and the difference presented statistical meaning (P＜0.05), after treating, the observation group was lower than the control group, and there was a significant difference (P＜0.05), the difference had no statistical meaning in Vm and Vp between both groups before treating (P＞0.05); Vm and Vp rose notably after treating, and the difference showed statistical meaning (P＜0.05); after treating, the observation group was higher than the control group, and there was a significant difference (P＜0.05). The difference had no statistical menaing in the levels of CRP, Hcy and MMP-9 between both groups before treating (P＞0.05); they reduced notably in the observation group after treating, and the difference had statistical meaning (P＜0.05); there was no obvious change in the control group after treating, and the difference had no statistical meaning (P＞0.05); the difference had statistical meaning between both groups after treating (P＜0.05). Conclusion: Ginkgo biloba leaf extract injection and continuous positive airway pressure are effective in the treatment of acute cerebral infarction complicated with OSAHS, the therapy could reduce the levels of CRP, Hcy and MMP-9, and improve cerebral hemodynamics.

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备注/Memo

备注/Memo:
收稿日期：2019-07-03*基金项目：河北省重点研发计划自筹项目(172777126)。作者简介：杨光(1982—)，男，硕士学位，主治医师。研究方向：卒中后认知障碍。
更新日期/Last Update: 2020-04-15