[1]马新,郑晶晶,张杰,等.血必净注射液联合替加环素对碳青霉烯泛耐药鲍曼不动杆菌感染的疗效[J].西部中医药,2020,33(07):110-113.[doi:10.12174/j.issn.1004-6852.2020.07.29]
 MA Xin,ZHENG Jingjing,ZHANG Jie,et al.The Effects of Xuebijing Injection and Tigecycline on Carbapenem Resistant Acinetobacter Baumannii Infection[J].Western Journal of Traditional Chinese Medicine,2020,33(07):110-113.[doi:10.12174/j.issn.1004-6852.2020.07.29]
点击复制

血必净注射液联合替加环素对碳青霉烯泛耐药鲍曼不动杆菌感染的疗效
分享到:

《西部中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
33
期数:
2020年07期
页码:
110-113
栏目:
报道·衷中参西
出版日期:
2020-07-15

文章信息/Info

Title:
The Effects of Xuebijing Injection and Tigecycline on Carbapenem Resistant Acinetobacter Baumannii Infection
文章编号:
1004-6852(2020)07-0110-04
作者:
马新郑晶晶张杰周志安边树伟白艳
1 承德市中医院,河北 承德 067000; 2 兴隆县中医医院;3 承德市中心医院
Author(s):
MA Xin1 ZHENG Jingjing1 ZHANG Jie2 ZHOU Zhian3 BIAN Shuwei 3 BAI Yan1
1 Chengde City TCM Hospital, Chengde 067000, China; 2 Xinglong County TCM Hospital; 3 Chengde Central Hospital
关键词:
感染碳青霉烯鲍曼不动杆菌广泛耐药血必净注射液替加环素临床疗效
Keywords:
infection carbapenem cextensive drug resistance acinetobacter baumannii Xuebijing injection tigecycline clinical effects
分类号:
R742
DOI:
10.12174/j.issn.1004-6852.2020.07.29
文献标志码:
B
摘要:
目的:探讨血必净注射液联合替加环素对碳青霉烯耐鲍曼不动杆菌感染的临床效果。方法:将泛耐药鲍曼不动杆菌肺部感染患者66例随机分为对照组与研究组各33例。对照组予替加环素,首剂100 mg,后50 mg,静脉滴注,每12 h 1次,维持治疗14天;研究组加用血必净注射液50 mL,每日两次,维持治疗14天。检测两组患者血清白细胞(white blood cell,WBC)、C反应蛋白(C-reaction protein,CRP)、降钙素原(procalcitonin,PCT)水平,并进行细菌学鉴定和药敏试验,评价细菌学疗效以及临床疗效。结果:与治疗前比较,治疗后两组患者WBC、CRP、PCT水平均降低(P<0.01),研究组低于对照组(P<0.01);细菌清除率对照组为30.3%(10/33),研究组为54.5%(18/33),两组比较差异有统计学意义( χ2=3.970,P=0.046);总有效率对照组为51.5%(17/33),研究组为75.8%(25/33),两组比较差异有统计学意义( χ2=4.190,P=0.041)。结论:血必净注射液联合替加环素对碳青霉烯泛耐药鲍曼不动杆菌感染疗效优于单纯替加环素。
Abstract:
Objective: To explore clinical effects of Xuebijing injection combined with tigecycline in treating the patients suffering carbapenem resistant acinetobacter baumannii infection. Methods: All 66 patients were randomized into the control group and the study group, 33 cases each group. The control group were given tigecycline, initial dose 100mg, later 50 mg, intravenous dripping, once every 12 hours, maintenance therapy for 14 days; the study group accepted Xuebijing injection, 50mL, twice each day, maintenance therapy for 14 days. To detect the levels of PCT, CRP and WBC between both groups, to perform bacteriological identification and drug sensitive test, and to assess clinical effects and curative effects of bacteriology. Results: Compared with before treating, the levels of WBC, CRP and PCT of both groups reduced after treating(P<0.01), the study group was lower than the control group(P<0.01), bacterial clearance rate of the control group was 30.3%(10/33), lower than 54.5%(18/33) of the study group, the difference had statistical meaning between both groups( χ2=3.970, P=0.046); total effective rate of the control group was 51.5%(17/33), lower than 75.8%(25/33) of the study group, and the difference showed statistical meaning between both groups( χ2=4.190, P=0.041). Conclusion: Xuebijing injection combined with tigecycline are superior to only tigecycline in treating carbapenem resistant acinetobacter baumannii infection.

相似文献/References:

[1]黄郢荷.循证护理对维持性血液透析导管感染发生情况的影响[J].西部中医药,2012,25(05):103.
 HUANG Ying-he.Effects of Evidence-based Nursing on Catheter Related Infections of Maintenance Hemodialysis[J].Western Journal of Traditional Chinese Medicine,2012,25(07):103.
[2]尹晓慧,王颖,程如意,等.VSD联合抗生素链珠菌植入术治疗股骨干骨折术后感染的护理体会[J].西部中医药,2014,27(02):129.
 YIN Xiaohui,WANG Ying,CHENG Ruyi,et al.Nursing Experience for the Patients with Infection after the Operation of Femoral Shaft Fracture Treated by VSD Combined with the Implantation of Antibiotics and Bone Cement[J].Western Journal of Traditional Chinese Medicine,2014,27(07):129.
[3]李旗,田福玲,郑德松.消毒愈肌膏对糖尿病足感染的影响[J].西部中医药,2014,27(09):86.
[4]石丽丽,周毓萍,程麦莉,等.某中医院多重耐药菌感染的流行特征及耐药性分析[J].西部中医药,2014,27(10):74.
[5]赵晓慧.环境因素对门诊手术室医院感染的影响[J].西部中医药,2014,27(12):53.
[6]胡建锋,王彩霞,谢培钧,等.骨折内固定术后感染原因分析及治疗策略[J].西部中医药,2016,29(07):137.
 HU Jianfeng,WANG Caixia,XIE Peijun,et al.Therapeutic Strategies and Postoperative Infection Causes of Fracture Internal Fixation[J].Western Journal of Traditional Chinese Medicine,2016,29(07):137.
[7]高静.重症再生障碍性贫血感染的护理及预防[J].西部中医药,2018,31(11):108.
 GAO Jing.Nursing and Prevention for the Infection of Grave Aplastic Anemia[J].Western Journal of Traditional Chinese Medicine,2018,31(07):108.
[8]苏莉,刘永民,刘永红,等.新型冠状病毒肺炎眼传播及其防控探讨[J].西部中医药,2020,33(S1):80.
 SU Li,LIU Yongmin,LIU Yonghong,et al.On Eye Transmission, the Prevention and Control of COVID-19[J].Western Journal of Traditional Chinese Medicine,2020,33(07):80.

备注/Memo

备注/Memo:
收稿日期:2019-05-20*基金项目:2016年承德市科学技术研究与发展计划项目(201601A020)。作者简介:马新(1981—),男,主治医师。研究方向:重症医学。
更新日期/Last Update: 2020-07-15