[1]赵军,师建平,董重阳,等.蒙药蓝刺头对绝经后骨质疏松症大鼠瘦素、β2肾上腺素受体的影响[J].西部中医药,2021,34(03):72-76.[doi:10.12174/j.issn.2096-9600.2021.03.19]
 ZHAO Jun,SHI Jianping,DONG Chongyang,et al.Effects of Mongolian Medicine Lancitou on Leptin and β2 Adrenaline Receptors of PMOP Rats[J].Western Journal of Traditional Chinese Medicine,2021,34(03):72-76.[doi:10.12174/j.issn.2096-9600.2021.03.19]
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蒙药蓝刺头对绝经后骨质疏松症大鼠瘦素、β2肾上腺素受体的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年03期
页码:
72-76
栏目:
民族医药
出版日期:
2021-03-15

文章信息/Info

Title:
Effects of Mongolian Medicine Lancitou on Leptin and β2 Adrenaline Receptors of PMOP Rats
作者:
赵军1, 师建平2, 董重阳2, 刘岩3, 常虹3, 刘晋1
1.内蒙古自治区中医医院,内蒙古 呼和浩特 010020
2.内蒙古医科大学中医学院
3.内蒙古医科大学附属医院
Author(s):
ZHAO Jun1, SHI Jianping2, DONG Chongyang2, LIU Yan3, CHANG Hong3, LIU Jin1
1.Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine, Hohehot 010020, China
2.TCM College, Inner Mongolia Medical University
3.Affiliated Hospital of Inner Mongolia Medical University
关键词:
骨质疏松绝经后蓝刺头瘦素肾上腺素受体大鼠
Keywords:
osteoporosis postmenopausalleptinadrenaline receptorsrats
分类号:
R285.5
DOI:
10.12174/j.issn.2096-9600.2021.03.19
摘要:
目的从预防骨丢失和促进骨再生两方面研究蒙药蓝刺头对绝经后骨质疏松症的防治作用,阐述其促进抑制破骨作用的信号通路。 方法通过去卵巢复制绝经后骨质疏松症模型;用蒙药蓝刺头、强骨胶囊和己烯雌酚分别灌胃模型大鼠90天,观察比较各组大鼠骨密度(bone mineral density,BMD)、骨小梁体积/组织体积(bone trabecula volume/tissue volume,BV/TV)、子宫重量/体质量(uterus weight/body weight,UW/BW)及瘦素(leptin,LEP)、股骨β2肾上腺素能受体(β2-adrenergic receptor,ADRβ2R)的表达。 结果与模型组比较,蒙药蓝刺头能从骨密度方面有效防治绝经后骨质疏松症模型大鼠疏松骨质,能降低绝经后骨质疏松症模型大鼠血清LEP水平(P<0.01)及ADRβ2R的表达(P<0.05)。 结论蒙药蓝刺头具有抑制骨吸收、促进骨形成的作用,其防治骨质疏松的作用机制涉及LEP/ADRβ2R信号通路,这为基于蒙医“肾主骨,治以补暖补精”理论防治骨质疏松提供了实验依据。
Abstract:
ObjectiveTo study the effects of mongolian medicine Lancitou(echinops sphaerocephalus) on the prevention of postmenopausal osteoporosis (PMOP) from preventing bone loss and promoting bone regeneration, and elucidate the signaling pathway of promoting and inhibiting bone-destroying effects. MethodsPMOP models were established by ovariectomizing; rat models were drenched with mongolian medicine Lancitou, Qianggu capsules and diethylstilbestrol for 90 days, to observe and compare bone mineral density (BMD) in different groups, bone trabecula volume/tissue volume (BV/TV), uterine weight/body weight (UW/BW), leptin (LEP) and the expressions of femoral β2 adrenergic receptors (ADRβ2R). ResultsCompared with the model group, mongolian medicine Lancitou could effectively prevent osteoporosis of PMOP rats from BMD and reduce LEP levels(P<0.01), and lower the epressions of ADRβ2R(P<0.05). ConclusionMongolian medicine Lancitou owns the effects of inhibiting bone resorption and promoting bone regeneration, and its mechanism of preventing osteoporosis involves LEP/ADRβ2R signaling pathway, and it could provide experimental reference for the prevention and treatment of PMOP by classical treatment of mongolian medicine.

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备注/Memo

备注/Memo:
赵军(1988—),男,硕士学位,主治医师。研究方向:骨伤科疾病的中医诊治。国家中医药管理局中医药传承与创新“百千万人才工程”项目(J20184832009);内蒙古医科大学“科技百万工程”联合项目[YKD2017KJBW(LH)064];内蒙古自治区第三批老蒙医药中医药专家学术经验继承项目(内卫计蒙中字[2019]126);内蒙古自治区草原英才创新团队“中医治未病”项目(CYYCTD2018)。
更新日期/Last Update: 2021-03-05