[1]李宏云,胡榕,汪明辉,等.抗感颗粒（儿童装）对普通型手足口病患儿免疫功能及炎性因子的影响[J].西部中医药,2021,34(04):1-4.[doi:10.12174/j.issn.2096-9600.2021.04.01]
　LI Hongyun,HU Rong,WANG Minghui,et al.The Influence of Kanggan Granules (for children) on Immunologic Function and Inflammatory Factor in Children Suffering Common Hand-foot-and-mouth Disease[J].Western Journal of Traditional Chinese Medicine,2021,34(04):1-4.[doi:10.12174/j.issn.2096-9600.2021.04.01]
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抗感颗粒（儿童装）对普通型手足口病患儿免疫功能及炎性因子的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年04期
页码:
1-4
栏目:
临床论著
出版日期:
2021-04-15

文章信息/Info

Title:
The Influence of Kanggan Granules (for children) on Immunologic Function and Inflammatory Factor in Children Suffering Common Hand-foot-and-mouth Disease
作者:
李宏云1, 胡榕1, 汪明辉1, 张晓清1, 沈咏梅2, 黄媛莉2, 王亚云2, 王存林2
1.常德市第一人民医院，湖南 常德 415003
2.成都高新好医生第一医院
Author(s):
LI Hongyun1, HU Rong1, WANG Minghui1, ZHANG Xiaoqing1, SHEN Yongmei2, HUANG Yuanli2, WANG Yayun2, WANG Cunlin2
1.Changde City the First People′s Hospital, Changde 415003, China
2.Chengdu Hi-tech Good doctor First Affiliated Hospital
关键词:
手足口病; 普通型; 抗感颗粒; 免疫功能; 炎性因子
Keywords:
hand-foot-and-mouth disease;  common type; granules; immunologic function; inflammatory factors
分类号:
R246.4
DOI:
10.12174/j.issn.2096-9600.2021.04.01
摘要:
目的探讨抗感颗粒（儿童装）对轻症型手足口病儿童免疫功能及炎性因子的影响。 方法将60例普通型手足口病患儿随机分为观察组与对照组各30例。两组均给予单磷酸阿糖腺苷治疗，观察组在此基础上给予抗感颗粒（儿童装）口服治疗。观察治疗前及治疗5天后两组免疫指标及炎性因子水平。 结果治疗后，观察组免疫球蛋白A（immunoglobulin A，IgA）较治疗前显著升高，免疫球蛋白M（immunoglobulin M，IgM）、免疫球蛋白G（immunoglobulin G，IgG）较治疗前显著下降，差异有统计学意义（P＜0.05）；治疗后，观察组IgA高于对照组，IgM、IgG显著低于对照组，差异有统计学意义（P＜0.05）。治疗后，两组CD3+、CD4+、CD8+显著升高，CD19+淋巴细胞水平均较治疗前显著下降，CD4+/CD8+较治疗前升高，差异均有统计学意义（P＜0.05）；治疗后，观察组CD3+、CD4+、CD8+显著高于对照组，CD19+淋巴细胞水平均显著低于对照组，CD4+/CD8+高于对照组，差异有统计学意义（P＜0.05）。治疗后，两组白细胞介素2（interleukin-2，IL-2）、白细胞介素4（interleukin-4，IL-4）、白细胞介素6（interleukin-6，IL-6）、白细胞介素10（interleukin-10，IL-10）、肿瘤坏死因子α（tumor necrosis factor α，TNF-α）、干扰素γ（interferon-γ，IFN-γ）均较治疗前显著下降，差异有统计学意义（P＜0.05）；治疗后，观察组IL-2、IL-4、IL-6、IL-10、TNF-α、IFN-γ显著低于对照组，差异有统计学意义（P＜0.05）。 结论抗感颗粒（儿童装）能够提高普通型手足口病患儿的免疫功能，降低炎性因子水平，从而改善患儿临床症状。
Abstract:
ObjectiveTo discuss the effects of Kanggan granules (for children) on immunologic function and inflammatory factors in children with mild hand-foot-and-mouth disease (HFMD). MethodsSixty children were randomly allocated to the observation group and the control group, 30 cases in each group. Both groups were given adenosine monophosphate, and the observation group took Kanggan granules (for children) orally based on Western medicine therapy. To detect the immune indexes and inflammatory factors of both groups before treating and five days after treating respectively. ResultsAfter treating, IgA of the observation group soared compared with before treating, IgM and IgG dropped than before treating, and the difference had statistical meaning (P＜0.05); after treating, IgA of the observation group was higher than that of the control group, IgM and IgG were lower than these of the control group, and the difference was statistically significant (P＜0.05). After treatment, the levels of CD3+, CD4+ and CD8+ increased notably in both groups, the levels of CD19+ decreased remarkably compared with before treating, CD4+/CD8+ lifted compared with before treating, and the difference had statistical meaning (P＜0.05); After treatment, the levels of CD3+, CD4+ and CD8+ of the observation group were notably higher than these of the control group, the levels of CD19+ lower than these of the control group, CD4+/CD8+ higher than that of the control group, and there were the significant differences (P＜0.05). After treatment, the levels of IL-2, IL-4, IL-6, IL-10, TNF-α and IFN-γ in both groups lowered notably compared with before treatment, and the difference had statistical meaning (P＜0.05); after treating, the observation group was lower than the control group in the levels of IL-2, IL-4, IL-6, IL-10, TNF-α and IFN-γ notably, the difference was statistically significant (P＜0.05). ConclusionKanggan granules (for children) could improve immunologic function in children with mild HFMD, lower the levels of inflammatory factors, thus improving clinical symptoms.

相似文献/References:

[1]林海鸿.银翘散治疗手足口病的临床观察[J].西部中医药,2013,26(06):64.
　LIN Haihong.Clinical Observation on YinQiaoSan in Treating Hand-foot-and-mouth Disease[J].Western Journal of Traditional Chinese Medicine,2013,26(04):64.
[2]刘丽霞,白龙.小儿柴桂退热颗粒治疗小儿手足口病81例[J].西部中医药,2012,25(08):68.
　LIU Li-xia,BAI Long.XiaoEr ChaiGui TuiRe Granules in Treating 81 Cases of Hand-Foot-and-Mouth Disease in Children[J].Western Journal of Traditional Chinese Medicine,2012,25(04):68.
[3]陈春.柴胡口服液联合利巴韦林分散片治疗儿童手足口病 50 例[J].西部中医药,2014,27(08):111.
[4]蔡钢,张选明,张辰龙,等.从“燥”论治新疆地区手足口病[J].西部中医药,2011,24(11):28.
[5]易天江.中西结合治疗对不同年龄段手足口病患儿心肌酶的影响[J].西部中医药,2016,29(01):113.
　YI Tianjiang.Influence of Integrative Medicine on Myocardial Enzymes of the Children with Hand-foot-and-mouth Disease at Different Ages[J].Western Journal of Traditional Chinese Medicine,2016,29(04):113.

备注/Memo

备注/Memo:
李宏云（1975—），女，主任医师。研究方向：小儿呼吸系统疾病的诊治。湖南省卫生计生委科研计划课题（B20180434）。
更新日期/Last Update: 2021-04-15