j.issn.2096-9600.2021.06.23]
点击复制

金匮肾气丸治疗创伤后应激障碍的临床疗效观察

分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

Title:: Observation on Clinical Effects of Jingui Shenqi Pills in the Treatment of Post-traumatic Stress Disorder

Author(s):: PENG Xiaoming, TANG Ke, GAO Libo, ZHANG Zhenwen, HUANG Shenghui; Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730020, China

Keywords:: post traumatic stress disorder; pills; brain derived neurotrophic factor; plasma cortisol

摘要:: 目的探讨金匮肾气丸治疗创伤后应激障碍（post-traumatic stress disorder，PTSD）的临床疗效。方法将100例创伤后应激障碍患者应用随机数字表法分为观察组和对照组，每组50例。对照组给予盐酸帕罗西汀治疗，观察组给予盐酸帕罗西汀联合金匮肾气丸治疗。观察两组创伤后应激障碍检查表评分、汉密尔顿抑郁量表评分、汉密尔顿焦虑量表评分，检测两组血浆皮质醇、脑源性神经营养因子水平，并记录两组不良反应发生情况。结果观察组治疗4、8周，汉密尔顿抑郁量表中焦虑/躯体化、认知障碍、睡眠障碍、绝望感评分低于对照组（P＜0.05）；汉密尔顿焦虑量表各因子评分均低于对照组（P＜0.05）；血浆皮质醇、脑源性神经营养因子水平均高于对照组（P＜0.05）。结论金匮肾气丸可能通过调节皮质醇、脑源性神经营养因子水平改善创伤后应激障碍患者的临床症状。

Abstract:: ObjectiveTo explore clinical effects of Jingui Shenqi pills in treating post-traumatic stress disorder (PTSD). MethodsOne hundred patients were separated in to the observation group and the control group using random number table method, 50 cases in each group. The control group was treated with paroxetine hydrochloride,and the observation group were given paroxetine hydrochloride and Jingui Shenqi pills.To observe PTSD inventory,HAMD and HAMA between both groups, to detect the levels of plasma cortisol and brain derived neurotrophic factor,and to record the incidence of adverse reaction between both groups. ResultsAfter treated for four and eight weeks,the observation group was lower than the control group in anxiety/somatization,cognitive impairment,sleep disorder, despair of HAMD(P<0.05);lower than the control group in the scores of each factor of HAMA(P<0.05);higher than the control group in the levels of plasma cortisol and brain derived neurotrophic factor(P<0.05). ConclusionJingui Shenqi pills could improve clinical symptoms of PTSD patients through regulating plasma cortisol and brain derived neurotrophic factor.

[1]张军梅.金匮肾气丸加味配合中药外敷治疗复发性口腔溃疡临床观察[J].西部中医药,2014,27(09):92.
[2]刘祥敏,张先庚△,薛秒.PTSD睡眠障碍流行病学及中医调护研究进展[J].西部中医药,2018,31(09):146.
　LIU Xiangmin,ZHANG Xiangeng,XUE Miao.Research Progress on TCM Nursing and Epidemiology of Sleep Disorder of PTSD Patients[J].Western Journal of Traditional Chinese Medicine,2018,31(06):146.
[3]李姝蒙,刘忠瀚,殷晓辉,等.基于旷场实验探究二十味沉香丸对卒中后PTSD模型大鼠的调节作用[J].西部中医药,2021,34(10):16.[doi:10.12174/j.issn.2096-9600.2021.10.04]
　LI Shumeng,LIU Zhonghan,YIN Xiaohui,et al.Regulatory Effects of Ershiwei Chenxiang Pills on PTSD Rat Models Based on Open Field Experiment[J].Western Journal of Traditional Chinese Medicine,2021,34(06):16.[doi:10.12174/j.issn.2096-9600.2021.10.04]

备注/Memo:: 彭晓明（1978—），男，硕士学位，副主任医师。研究方向：精神心理疾病的中西医结合诊治。甘肃自然科学基金（1606RJZA163）。

更新日期/Last Update: 2021-06-15