[1]何琼,高晓东,李晓琴,等.结核丸联合抗结核药物治疗反复难治性结核病的临床疗效观察[J].西部中医药,2021,34(06):110-114.[doi:10.12174/j.issn.2096-9600.2021.06.27]
　HE Qiong,GAO Xiaodong,LI Xiaoqin,et al.Observation on Clinical Effects of Tuberculosis Pills Combined with Antituberculosis Drugs in the Treatment of Recurrent Refractory Tuberculosis[J].Western Journal of Traditional Chinese Medicine,2021,34(06):110-114.[doi:10.12174/j.issn.2096-9600.2021.06.27]
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结核丸联合抗结核药物治疗反复难治性结核病的临床疗效观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年06期
页码:
110-114
栏目:
衷中参西
出版日期:
2021-06-15

文章信息/Info

Title:
Observation on Clinical Effects of Tuberculosis Pills Combined with Antituberculosis Drugs in the Treatment of Recurrent Refractory Tuberculosis
作者:
何琼1, 高晓东1, 李晓琴2, 黄海涛3, 李江红4, 满世军5, 高佩媛1, 赵天莹1
1.甘肃省疾病预防控制中心,甘肃 兰州 730000
2.武威凉州区传染病医院
3.天水市传染病医院
4.天水市疾病预防控制中心
5.武威市疾病预防控制中心
Author(s):
HE Qiong1, GAO Xiaodong1, LI Xiaoqin2, HUANG Haitao3, LI Jianghong4, MAN Shijun5, GAO Peiyuan1, ZHAO Tianying1
1.Gansu Provincial Center for Disease Control and Prevention, Lanzhou 730000, China
2.Liangzhou District Hospital of Infectious Disease of Wuwei
3.Tianshui Hospital of Infectious Disease
4.Tianshui Center for Disease Control and Prevention
5.Wuwei Center for Disease Control and Prevention
关键词:
结核病; 反复性; 难治性; 结核丸; 临床疗效; 中医药; 痰检
Keywords:
recurrent refractory tuberculosis; tuberculosis pills; clinical observation; TCM; sputum examination
分类号:
R521
DOI:
10.12174/j.issn.2096-9600.2021.06.27
摘要:
目的观察结核丸联合化疗治疗反复性、难治性结核病的临床疗效。 方法选择202例确诊的复治涂阳肺结核患者，随机分为观察组和对照组，每组101例。对照组给予单纯抗结核药物治疗，观察组内服抗结核药物联合中药结核丸治疗。观察两组临床疗效、痰检结果、痰涂片转阴率、症状变化及肝功能指标。 结果观察组临床有效率［99.01%（100/101）］优于对照组［92.08%（93/101）］（P＜0.05）。观察组治疗第8、24周痰检转阴率分别为96.04%（97/101）及100%（101/101）；对照组治疗第8、24周痰检转阴率均为99.01%（100/101），两组比较差异无统计学意义（P＞0.05）。治疗第4、8、24周后，ALT及AST水平，观察组均较对照组同期降低明显，差异有统计学意义（P＜0.05）。 结论结核丸联合化疗治疗反复性、难治性肺结核，可提高临床疗效、痰检转阴率，改善临床症状，且可缓解肝功能损伤。
Abstract:
ObjectiveTo observe clinical effects of tuberculosis pills and chemotherapy in the treatment of recurrent refractory tuberculosis. MethodsAll 202 patients who were confirmed and retreatment of smear positive pulmonary tuberculosis were selected and randomized into the observation group and the control group, 101 cases in each group. The control group accepted only antituberculosis drugs, and the observation group oral antituber-culosis drugs and tuberculosis pills. To observe clinical effects, the results of sputum examination, negative conversion rate of sputum smear, the changes of the symptoms and the indexes of liver function between both groups. ResultsClinical effective rate of the observation group was 99.01% (100/101), superior to 92.08% (93/101) of the control group (P<0.05); the results of sputum examination, negative conversion rates of the observation group at the eighth and 24th week of treatment were 96.04% (97/101) and 100% (101/101) respectively, while the rates of the control group at the eighth and 24th week of treatment were 99.01% (100/101) and 99.01% (100/101), and the difference had no statistical meaning between both groups (P>0.05); after four, eight and 24 weeks of treatment, the levels of ALT of the observation group lowered compared with these of the control group, and the difference had statistical meaning (P<0.05); after eight and 24 weeks of treatment, the levels of AST of the observation group reduced compared with the control group, and the difference showed statistical meaning (P<0.05). ConclusionTuberculosis pills and chemotherapy in the treatment of recurrent refractory tuberculosis could raise clinical effects and negative conversion rates of sputum examination, improve clinical symptoms and relieve liver function damage.

相似文献/References:

[1]陈晓艳,张婉,戈艳蕾,等.路北区儿童家长结核病防治知识调查[J].西部中医药,2014,27(08):41.
[2]李富良.金昌市城区2005—2011年结核病流行病学分析[J].西部中医药,2013,26(08):64.
　LI Fuliang.Epidemiological Analysis of Tuberculosis from 2005 to 2011 in the Urban Area of Jinchang[J].Western Journal of Traditional Chinese Medicine,2013,26(06):64.
[3]王爱梅,卢敏芳.中西医结合健康教育对武威市1 600名学生结核病知晓率的影响[J].西部中医药,2019,32(08):54.
　WANG Aimei,LU Minfang.Influence of Integrative Medicine Health Education on Tuberculosis Awareness Rate of 1 600 Students in Wuwei City[J].Western Journal of Traditional Chinese Medicine,2019,32(06):54.

备注/Memo

备注/Memo:
何琼（1975—），女，硕士学位，副主任医师。研究方向：艾滋病的中西医结合防治。
更新日期/Last Update: 2021-06-15