小剂量利妥昔单抗联合银屑病1号方治疗系统性红斑狼疮疗效观察-《西部中医药》

文章信息/Info

Title:: Clinical Observation on Low Dose Rituximab Combined with Psoriasis No.1 Formula in Treating Systemic Lupus Erythematosus

Author(s):: NI Fei¹, XU Ping², PAN Jie²; 1.Liyang City People's Hospital, Liyan 213300, China
2.Liyang Branch of Jiangsu Provincial People's Hospital

摘要:: 目的观察小剂量利妥昔单抗联合银屑病1号方治疗系统性红斑狼疮的临床疗效。方法选择81例系统性红斑狼疮患者，随机分为观察组（40例）和对照组（41例）。对照组采用小剂量利妥昔单抗治疗，观察组联用银屑病1号方，观察两组临床疗效，血清肿瘤坏死因子α（tumor necrosis factor-α，TNF-α）、白细胞介素17（interleukin-17，IL-17）、免疫球蛋白G（immunoglobulin G，IgG）、抗核抗体（antinuclear antibody，ANA）、S100钙结合蛋白P（S100 calcium binding protein，S100P）、泌乳素（prolactin，PRL）、血清补体C3、环氧二十碳三烯酸（epoxyeicosatrienoic acids，EET）水平。结果总有效率观察组［80.00%（32/40）］明显高于对照组［58.54%（24/41）］（P＜0.05）；治疗后，两组TNF-α、IL-17、IgG、ANA、S100P、PRL水平均治疗前明显降低，血清补体C3、EET水平明显升高（P＜0.05），且观察组较对照组改善更明显（P＜0.05）。结论小剂量利妥昔单抗联合银屑病1号方治疗系统性红斑狼疮疗效显著，不仅能改善免疫功能指标，还能改善疾病相关血清因子水平。

Abstract:: ObjectiveTo study clinical effects of low dose rituximab and psoriasis No.1 formula in treating systemic lupus erythematosus(SLE). MethodsAll 81 SLE patients were chosen and randomized into the observation group(40 cases) and the control group(41 cases).The control group adopted low dose rituximab,and the observation group psoriasis No.1 formula, to observe clinical effects,the levels of TNF-α,IL-17,IgG,ANA,S100P, PRL, serum complement C3 and EET in two groups. ResultsTotal effective rate of the observation group was[80.00%(32/40)], higher than[58.54%(24/41)] of the control group (P<0.05); after treating, the levels of TNF-α,IL-17, IgG, ANA, S100P and PRL reduced notably in the serum of both groups than these before treating(P<0.05), the levels of C3 and EET in the serum increased obviously(P<0.05), and the improvement of the observation group was more notable compared with that of the control group(P<0.05). ConclusionLow dose rituximab and psoriasis No.1 own notable effects in treating SLE, it could not only improve immune function indexes,but also improve the levels of disease-related serum factors.

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