[1]安小平,崔庆荣,康学东,等.黄连化浊方联合二甲双胍治疗肥胖型2型糖尿病合并血脂异常临床研究[J].西部中医药,2021,34(09):99-102.[doi:10.12174/j.issn.2096-9600.2021.09.27]
　AN Xiaoping,CUI Qingrong,KANG Xuedong,et al.Clinical Study on Huanglian Turbidity-resolving Prescription and Metformin in the Treatment for Obesity Type 2 Diabetes Mellitus with Dyslipidemia[J].Western Journal of Traditional Chinese Medicine,2021,34(09):99-102.[doi:10.12174/j.issn.2096-9600.2021.09.27]
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黄连化浊方联合二甲双胍治疗肥胖型2型糖尿病合并血脂异常临床研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年09期
页码:
99-102
栏目:
衷中参西
出版日期:
2021-09-15

文章信息/Info

Title:
Clinical Study on Huanglian Turbidity-resolving Prescription and Metformin in the Treatment for Obesity Type 2 Diabetes Mellitus with Dyslipidemia
作者:
安小平1, 崔庆荣1, 康学东1, 王道坤2
1.甘肃中医药大学附属医院糖尿病科，甘肃 兰州 730020
2.甘肃中医药大学
Author(s):
AN Xiaoping1, CUI Qingrong1, KANG Xuedong1, WANG Daokun2
1.Department of Diabetes Mellitus, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730020, China
2.Gansu University of Chinese Medicine
关键词:
2型糖尿病; 肥胖型; 血脂异常; 黄连化浊方; 二甲双胍; 临床研究
Keywords:
type 2 diabetes mellitus;  obesity; dyslipidemia; turbidity-resolving prescription; metformin; clinical study
分类号:
R587
DOI:
10.12174/j.issn.2096-9600.2021.09.27
摘要:
目的观察黄连化浊方联合二甲双胍治疗肥胖型2型糖尿病(type 2 diabetes mellitus，T2DM)合并血脂异常的临床疗效及安全性。 方法将肥胖型2型糖尿病合并血脂异常患者76例随机分为治疗组和对照组各38例。治疗组予黄连化浊方联合二甲双胍治疗，对照组予二甲双胍治疗。共治疗16周，观察治疗前后两组患者体质量指数（body mass index，BMI）、糖化血红蛋白(glycosylated hemoglobin，HbAlc)、空腹血糖（fasting blood glucose，FBG）、餐后2 h血糖（2-hour postprandial blood glucose，2hPG）、胰岛素（INSan）、血C肽（C-P）、β细胞功能指数（HBCI）、总胆固醇（total cholesterol，TC）、甘油三酯（triglyceride，TG）、脂联素（adiponectin，APN）变化情况及不良反应。 结果治疗组降糖、降脂及减轻体质量的效果优于对照组，两组比较差异有统计学意义（P＜0.05）；不良反应两组比较差异无统计学意义（P＞0.05）。 结论黄连化浊方联合二甲双胍能降低肥胖型T2DM合并血脂异常患者血糖、血脂，减轻体质量，效果优于单纯二甲双胍治疗。
Abstract:
ObjectiveTo observe clinical effects and the safety of Huanglian turbidity-resolving prescription and metformin in the treatment for obesity type 2 diabetes mellitus (T2DM) with dyslipidemia. MethodsAll 76 patients were randomized into the treatment group and the control group, 38 cases in each group. The treatment group were treated by Huanglian turbidity-resolving prescription and metformin, and the control group took metformin. To observe the changes of BMI, HbA1c, FPG, 2hPG, INS, C-P, HOMA-β, TC, TG and APN and adverse reaction in both groups before and after treating after they were treated for 16 weeks. ResultsThe effects of lowering blood glucose, blood lipid and body mass in the treatment group were superior to these of the control gorup, and the difference had statistical meaning between both groups (P<0.05); the difference had no statistical meaning between both groups in adverse reaction (P>0.05). ConclusionHuanglian turbidity-resolving prescription combined with metformin could lower the levels of blood glucose and blood lipid in the patients, reduce body mass, and the effects are superior to these of only metformin.

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备注/Memo

备注/Memo:
安小平（1981—），女，硕士学位，副主任医师。研究方向：糖尿病及胃肠疾病的中西医结合治疗。甘肃省中医药管理局项目（GZK-2014-4）。
更新日期/Last Update: 2021-09-15