[1]王艳,达春和,胡杰亮,等.苦参碱对胃癌化疗后不良反应及炎症标志物PLA2、SAA的影响[J].西部中医药,2022,35(04):117-119.[doi:10.12174/j.issn.2096-9600.2022.04.27]
　WANG Yan,DA Chunhe,HU Jieliang,et al.Effects of Matrine on Adverse Reaction and Inflammatory Markers PLA2 and SAA after Chemotherapy for Gastric Cancer[J].Western Journal of Traditional Chinese Medicine,2022,35(04):117-119.[doi:10.12174/j.issn.2096-9600.2022.04.27]
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苦参碱对胃癌化疗后不良反应及炎症标志物PLA2、SAA的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年04期
页码:
117-119
栏目:
出版日期:
2022-04-15

文章信息/Info

Title:
Effects of Matrine on Adverse Reaction and Inflammatory Markers PLA2 and SAA after Chemotherapy for Gastric Cancer
作者:
王艳, 达春和, 胡杰亮, 屈蕾蕾, 张媛媛, 包丽, 张强
甘肃中医药大学第三附属医院，甘肃 白银 730900
Author(s):
WANG Yan, DA Chunhe, HU Jieliang, QU Leilei, ZHANG Yuanyuan, BAO Li, ZHANG Qiang
The Third Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Baiyin 730900, China
关键词:
胃癌; 苦参碱; 化疗; 磷脂酶A2; 血清淀粉样蛋白A; 肿瘤标志物
Keywords:
gastric cancer; matrine; chemotherapy; PLA2; serum amyloid A; tumor markers
分类号:
R735
DOI:
10.12174/j.issn.2096-9600.2022.04.27
文献标志码:
B
摘要:
目的探讨苦参碱对胃癌化疗后不良反应及炎症标志物磷脂酶A2（phospholipase A2，PLA2）、血清淀粉样蛋白A（serum amyloid A，SAA）的影响。 方法选择Ⅱ～Ⅲ期胃癌术后化疗患者126例，随机分为观察组（70例）和对照组（56例）。观察组采用苦参碱+FOLFOX化疗方案，对照组采用单纯FOLFOX化疗方案。观察两组化疗后不良反应发生率，血清炎症标志物PLA2、SAA水平及肿瘤标志物CEA，CA199，CA724水平的变化。 结果观察组在化疗开始后，恶心、脱发、发热、口腔溃疡，静脉炎等不良反应发生率明显低于对照组（P＜0.05），血清中PLA2、SAA、CEA、CA199、CA724水平明显低于对照组（P＜0.05）。 结论苦参碱可以显著降低炎症标志物水平，减少全身炎症综合症的发生，对化疗药物具有协同增敏作用。
Abstract:
ObjectiveTo survey the effects of matrine on adverse reaction and PLA2 and SAA after chemotherapy for gastric cancer. MethodsAll 126 patients undergoing chemotherapy after the surgery of gastric cancer at stage Ⅱ to Ⅲ were chosen, randomized into the observation group (70 cases) and the control group (56 cases). The observation group adopted matrine+FOLFOX chemotherapy regimen, and the control group used FOLFOX chemotherapy regimen only. To observe the incidence of adverse reaction after the chemotherapy, the levels of serum inflammatory markers including PLA2, SAA, the levels of tumor markers CEA, CA199 and CA724. ResultsIn the observation group after the chemotherapy, the incidences of adverse reactions including nausea, hair loss, fever, oral ulcer, phlebitis were lower than these of the control group (P<0.05), the levels of PLA2, SAA, CEA, CA199 and CA724 were lower than these of the control group (P<0.05). ConclusionMatrine could notably decrease the levels of inflammatory markers, reduce the incidence of systemic inflammatory syndrome, and it has synergistic sensitizing effect on chemotherapy drugs.

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备注/Memo

备注/Memo:
王艳（1976—），女，副主任护师。研究方向：肿瘤疾病的术后护理。甘肃省中医药管理局科研课题（GZK-2014-55）。
更新日期/Last Update: 2022-06-24