[1]马思遥,任延毅,王雪冰,等.养阴活血类中药复方治疗放射性肺炎的Meta分析[J].西部中医药,2023,36(01):70-78.[doi:10.12174/j.issn.2096-9600.2023.01.17]
 MA Siyao,REN Yanyi,WANG Xuebing,et al.Meta-analysis of Compound Traditional Chinese Medicine of Nourishing-Yin and Promoting Blood Circulation in the Treatment of Radioactive Pneumonia[J].Western Journal of Traditional Chinese Medicine,2023,36(01):70-78.[doi:10.12174/j.issn.2096-9600.2023.01.17]
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养阴活血类中药复方治疗放射性肺炎的Meta分析
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年01期
页码:
70-78
栏目:
出版日期:
2023-01-15

文章信息/Info

Title:
Meta-analysis of Compound Traditional Chinese Medicine of Nourishing-Yin and Promoting Blood Circulation in the Treatment of Radioactive Pneumonia
作者:
马思遥, 任延毅, 王雪冰, 王沈玉
中国医科大学肿瘤医院/辽宁省肿瘤医院,辽宁 沈阳 110042
Author(s):
MA Siyao, REN Yanyi, WANG Xuebing, WANG Shenyu
Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, China
关键词:
肺炎放射性肿瘤中西医结合养阴活血Meta分析中药复方
Keywords:
pneumonia radioactivetumorintegrated Traditional Chinese and Western medicinenourishing and promoting blood circulationMeta analysiscompound traditional Chinese medicine
分类号:
R319
DOI:
10.12174/j.issn.2096-9600.2023.01.17
文献标志码:
A
摘要:
目的利用Meta分析方法对养阴活血类中药复方治疗放射性肺炎的作用进行系统评价。 方法检索PubMed、Embase、Medline、中国期刊全文数据库(China National Knowledge Infrastructure,CNKI)、维普中文科技期刊全文数据库(Vip Chinese Science and Technology Journal Database,VIP)及万方数据库(WanFang Data)等常用中、英文数据库,检索时间为从建库至2020年5月1日,筛选符合纳入标准的文献进行系统评价。 结果共纳入40项研究,涉及2528例患者。总有效率观察组优于对照组(P<0.01,RR=1.32,95%CI[1.27,1.38]);治疗后观察组影像学改善优于对照组(P<0.01,SMD=1.12,95%CI[1.01,1.25]),血浆白细胞介素6(interleukin-6,IL-6)变化较对照组明显(P<0.01,SMD=-0.96,95%CI[-1.18,-0.75]);血浆肿瘤坏死因子α(tumor necrosis factor α,TNF-α)、血浆转化生长因子β(transforming growth factor-β,TGF-β)水平两组治疗后比较差异无统计学意义;治疗后观察组VC改善优于对照组(P<0.01,SMD=0.74,95%CI[0.50,0.99]);治疗后观察组第一秒用力肺活量/潮气量比值(first second forced vital capacity/tidal volume,FEV1/FVC)百分比缓解优于对照组(P<0.01,SMD=0.65,95%CI[0.41,0.90])。 结论养阴活血类中药复方在放射性肺炎患者总有效率、影像学、IL-6水平及肺功能(VC、FEV1/FVC百分比)方面有疗效优势。
Abstract:
ObjectiveTo perform systematic evaluation of compound traditional Chinese medicine of nourishing-Yin and promoting blood circulation in the treatment of radioactive pneumonia by utilizing Meta-analysis method. MethodsThe literature which met the inclusion criteria were searched from PubMed, Embase, Medline, CNKI, VIP and Wanfang, and the retrieval time was from the data building time to May 1, 2020, to conduct systematic evaluation. ResultsA total of 40 studies were included, involving 2528 patients. Total effective rate of the observation group was better than that of the control group (P<0.01, RR=1.32, 95% CI[1.27, 1.38]); after the treatment, the observation group was better than the control group in imaging improvement (P<0.01, SMD=1.12, 95% CI[1.01, 1.25]), the changes of IL-6 were more noticeable than these of the control group (P<0.01, SMD=-0.96, 95% CI[-1.18, -0.75]). The difference had no statistical meaning in the levels of TNF-α and TGF-β between both groups after the treatment. After the treatment, VC improvement of the observation group was better than that of the control group (P<0.01, SMD=0.74, 95% CI[0.50, 0.99]). The observation group was superior to the control group in FEV1/FVC% (P<0.01, SMD=0.65, 95% CI[0.41, 0.90]). ConclusionCompound traditional Chinese medicine of nourishing-Yin and promoting blood circulation owns the advantages in the clinical efficacy of total effective rate, imaging, the levels of IL-6, pulmonary function (VC and FEV1/FVC%) in patients with radioactive pneumonia.

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备注/Memo

备注/Memo:
马思遥(1986—),女,硕士学位。研究方向:肺癌、结肠癌、乳腺癌及其并发症的中西医结合治疗。辽宁省自然科学基金指导计划(2019-ZD-0579,2019-ZD-0582);辽宁中医药大学中医脏象理论及应用国家教育部重点实验室开放基金(ZYZX1904)。
更新日期/Last Update: 2023-01-15