清金化痰汤治疗痰热郁肺型哮喘慢阻肺重叠临床研究-《西部中医药》

文章信息/Info

Title:: Clinical Study on Qingjin Huatan Decoction in the Treatment of Phlegm-heat Stagnating in Lung Pattern ACO

作者:: 吴红英¹, 许光兰², 陈小丽¹, 陈青蓝¹, 明春玉¹; 1.广西中医药大学，广西南宁 530001
2.广西中医药大学第一附属医院，广西南宁 530001

Author(s):: WU Hongying¹, XU Guanglan², CHEN Xiaoli¹, CHEN Qinglan¹, MING Chunyu¹; 1.Guangxi University of Chinese Medicine, Nanning 530001, China
2.The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530001, China

Keywords:: asthma-COPD overlap; decoction; phlegm-heat stagnating in lung; clinical study

摘要:: 目的观察清金化痰汤对痰热郁肺型哮喘慢阻肺重叠的临床疗效。方法将60例哮喘慢阻肺重叠患者，按照随机数字表法分为观察组和对照组，每组30例。两组均予布地奈德福莫特罗吸入剂治疗，观察组加服清金化痰汤，疗程4周。比较两组肺功能［第一秒用力呼气容积（forced expiratory volume in one second，FEV₁）/用力肺活量（forced vital capcacity，FVC）］、呼出气一氧化氮（fractional expired nitric oxide，FeNO）、血清炎症因子水平［白细胞介素4（interleukin 4，IL-4）、白细胞介素6（interleukin 6，IL-6）、肿瘤坏死因子α（tumor necrosis factor α，TNF-α）］。结果治疗后，两组FEV₁值、FEV₁/FVC较治疗前增高，FeNO、IL-4、IL-6、TNF-α水平降低（P＜0.05）；且观察组各项指标水平改善优于对照组（P＜0.05）。观察组总有效率［96.67%（29/30）］高于对照组［86.67%（26/30）］（P＜0.05）。结论清金化痰汤可有效改善哮喘慢阻肺重叠痰热郁肺患者的肺功能、减轻炎症反应，提高临床疗效。

Abstract:: ObjectiveTo observe clinical effects of Qingjin Huatan decoction in the treatment of asthma-COPD overlap (ACO) of phlegm-heat stagnating in lung pattern. MethodsSixty ACO patients were allocated to the observation group and the control group according to random number table method, 30 cases in each group. Both groups were treated by budesonide and formoterol fumarate powder for inhalation, the observation group took Qingjin Huatan decoction, and the course was four weeks. To compare pulmonary function [FEV₁/FVC], FeNO, the levels of serum inflammatory factor [IL-4, IL-6 and TNF-α] between both groups. ResultsAfter the treatment, FEV₁ and FEV₁/FVC increased in the two groups, the levels of FeNO, IL-4, IL-6 and TNF-α reduced (P<0.05); and the improvements of different indexes of the observation group were better than these of the control group (P<0.05). Total effective rate of the observation group was [96.67%(29/30)], higher than [86.67%(26/30)] of the control group (P<0.05). ConclusionQingjin Huatan decoction could effectively improve lung function, relieve inflammatory reaction and raise clinical effects in the treatment ofACO of phlegm-heat stagnating in lung pattern.