[1]王鼎盛,赵天莹,何琼,等.基于中医传承辅助平台分析布鲁氏菌病瘀血阻络证的用药规律[J].西部中医药,2023,36(08):59-65.[doi:10.12174/j.issn.2096-9600.2023.08.15]
　WANG Dingsheng,ZHAO Tianying,HE Qiong,et al.The Medication Rules of Blood Stasis Obstructing Collateral Pattern Brucellosis Based on TCMISS[J].Western Journal of Traditional Chinese Medicine,2023,36(08):59-65.[doi:10.12174/j.issn.2096-9600.2023.08.15]
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基于中医传承辅助平台分析布鲁氏菌病瘀血阻络证的用药规律
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年08期
页码:
59-65
栏目:
出版日期:
2023-08-15

文章信息/Info

Title:
The Medication Rules of Blood Stasis Obstructing Collateral Pattern Brucellosis Based on TCMISS
作者:
王鼎盛1, 赵天莹1, 何琼1, 席进孝1, 王小荣2, 关宏1, 周晓艳1, 赵琦1
1.甘肃省疾病预防控制中心,甘肃 兰州 730000
2.甘肃中医药大学，甘肃 兰州 730020
Author(s):
WANG Dingsheng1, ZHAO Tianying1, HE Qiong1, XI Jinxiao1, WANG Xiaorong2, GUAN Hong1, ZHOU Xiaoyan1, ZHAO Qi1
1.Gansu Center for Disease Control and Prevention, Lanzhou 730000, China
2.Gansu University of Chinese Medicine, Lanzhou 730020, China
关键词:
布鲁氏菌病; 瘀血阻络证; 中医传承辅助系统; 数据挖掘; 用药规律
Keywords:
brucellosis; blood stasis obstructing collateral pattern; TCMISS; data mining; medication rules
分类号:
R378.5+1
DOI:
10.12174/j.issn.2096-9600.2023.08.15
文献标志码:
A
摘要:
目的分析中医治疗布鲁氏菌病瘀血阻络证的方药特征信息，探索组方用药规律，挖掘有效的药物组合及新处方。 方法检索相关数据库并查阅资料，收集关于布鲁氏菌病瘀血阻络证的文献和医案，筛选治疗该病证的方剂。基于中医传承辅助平台V2.5建立方药特征数据库，并通过关联规则分析法、改进互信息法、熵层次聚类等方法，对处方用药进行数据分析，包括药物四气、五味、归经分布以及用药频次统计，组方规律和新方等。 结果筛选出关于布鲁氏菌病瘀血阻络证的组方41首，中药64味，使用频次最高的五味中药为桃仁、川芎、当归、红花、秦艽，并获得核心药物组合14个，用药规则以红花、川芎、丹参、桃仁、当归、地龙、秦艽之间的配合为主，得出7个新的处方。 结论布鲁氏菌病瘀血阻络证主要以补血活血，疏经行气通络为治疗原则，且活血药与补血药、活血药与祛风湿药、活血药与通络药之间多以“相须”“相使”为主，为临床用药规律及科学研究提供数据支撑。
Abstract:
ObjectiveTo analyze the characteristic information of prescription and drugs in the treatment of blood stasis obstructing collateral pattern brucellosis by TCM, explore the medication rules of the prescription, and unearth the effective drug combination and new prescription. MethodsThe literature and medical cases of blood stasis obstructing collateral pattern brucellosis were collected by searching the relevant database and consulting the data, to screen the prescriptions of treating the disease. The database of prescription and drugs was established based on TCMISS V2.5, the data of the prescribed herbs, including four properties, five flavors, meridian tropism and distribution, medication frequency statistics, the rule of the prescriptions and new prescription, was analyzed through association rule analysis method, informed mutual information method, entropy hierarchical clustering. ResultsA total of 41 prescriptions and 64 herbs were selected, the most frequently used herbs were Taoren (Persicae semen), Chuanxiong(Chuanxiong rhizoma), Danggui (Angelicae sinensis radix), Honghua (Carthami flos) and Qinjiao (Gentianae macrophyllae radix), 14 core drug combination and seven new prescriptions were yielded, the medication rule were mainly the compatibility between Honghua, Chuanxiong, Danshen (Salviae miltiorrhizae radix et rhizoma), Taoren, Danggui, Dilong (pheretima) and Qinjiao. ConclusionBlood stasis obstructing collateral pattern brucellosis principally adopts tonifying and activating blood, dredging collateral, promoting Qi circulation and unobstructing the collateral as therapeutic principles, meanwhile, the drugs of activating blood, and the ones of enriching blood, the ones of activating blood, and the ones for rheumatism, the ones of activating blood, and the one of unobstructing the collateral are mostly "mutually promoted" or "mutually assisted", which could provide data support for clinical drug use and scientific study.

相似文献/References:

[1]杨宏伟.中药口服、塌渍联合西药治疗布鲁氏菌病疗效观察[J].西部中医药,2022,35(05):144.[doi:10.12174/j.issn.2096-9600.2022.05.33]
　YANG Hongwei.Clinical Observation on Oral Administration of Herbs, Hot Compressing with Herbs Combined with Western Medicine in the Treatment of Brucellosis[J].Western Journal of Traditional Chinese Medicine,2022,35(08):144.[doi:10.12174/j.issn.2096-9600.2022.05.33]
[2]高晓峰,程慧娟,刘利娟,等.中药针剂联合中医特色疗法治疗脑梗死急性期瘀血阻络证疗效回顾性分析[J].西部中医药,2022,35(09):115.[doi:10.12174/j.issn.2096-9600.2022.09.23]
　GAO Xiaofeng,CHENG Huijuan,LIU Lijuan,et al.Retrospective Analysis of Curative Effects of Traditional Chinese Medicine Injection in Combination with TCM-featured Therapy in the Treatment of Acute Cerebral Infarction of Blood Stasis Obstructing Collaterals Pattern[J].Western Journal of Traditional Chinese Medicine,2022,35(08):115.[doi:10.12174/j.issn.2096-9600.2022.09.23]

备注/Memo

备注/Memo:
王鼎盛（1975—），男，硕士学位，主任医师。研究方向：布鲁氏菌病防治与研究。2019年甘肃省中医药科研课题（GZK-2019-58）。
更新日期/Last Update: 2023-08-15