[1]史凡凡,赵继荣,雒永生,等.中医药干预Wnt/β-catenin信号通路治疗激素性骨质疏松症的研究进展[J].西部中医药,2024,37(03):73-76.[doi:10.12174/j.issn.2096-9600.2024.03.13]
　SHI Fanfan,ZHAO Jirong,LUO Yongsheng,et al.Research Progress of the Treatment of Glucocorticoid-induced Osteoporosis with Traditional Chinese Medicine Intervention on Wnt/β-catenin Signaling Pathway[J].Western Journal of Traditional Chinese Medicine,2024,37(03):73-76.[doi:10.12174/j.issn.2096-9600.2024.03.13]
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中医药干预Wnt/β-catenin信号通路治疗激素性骨质疏松症的研究进展
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年03期
页码:
73-76
栏目:
研究进展
出版日期:
2024-03-15

文章信息/Info

Title:
Research Progress of the Treatment of Glucocorticoid-induced Osteoporosis with Traditional Chinese Medicine Intervention on Wnt/β-catenin Signaling Pathway
作者:
史凡凡1, 赵继荣1, 雒永生2, 马同2, 陈文2, 蔡毅1, 张天龙2, 杨涛1, 张立存1, 李玮农1, 杨文通1, 蒋鹏1
1.甘肃中医药大学，甘肃 兰州 730030
2.甘肃省中医院，甘肃 兰州 730050
Author(s):
SHI Fanfan1, ZHAO Jirong1, LUO Yongsheng2, MA Tong2, CHEN Wen2, CAI Yi1, ZHANG Tianlong2, YANG Tao1, ZHANG Licun1, LI Weinong1, YANG Wentong
1.Gansu University of Chinese Medicine, Lanzhou 730030, China
2.Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
关键词:
骨质疏松症; 激素性; Wnt/-catenin信号通路; 中医药
Keywords:
osteoporosis;  glucocorticoid-induced; Wnt/-catenin signaling pathway; traditional Chinese medicine
分类号:
R274.9
DOI:
10.12174/j.issn.2096-9600.2024.03.13
文献标志码:
A
摘要:
对Wnt/β-catenin信号通路与激素性骨质疏松症（glucocorticoid-induced osteoporosis，GIOP）相关性及中药单体、中药复方干预Wnt/β-catenin信号通路治疗GIOP的研究进行综述，指出当Wnt/β-catenin信号通路受到抑制时，骨形成减少的同时骨吸收增加，从而诱发GIOP；中药单体及复方通过调控Wnt/β-catenin信号通路抑制剂Dickkopf相关蛋白1（dickkopf related protein 1，DKK1）、组织蛋白酶K（cathepsin K，CTSK）、Wnt抑制因子1（Wnt inhibitory factor 1，WIF1）、糖原合成酶激酶3β（glycogen synthetase kinase-3β，GSK3β）、骨硬化蛋白（sclerostin protein，SOST）等表达水平，再次激活Wnt/β-catenin信号通路，从而达到防治GIOP的目的。因此，探讨中医药对Wnt/β-catenin信号通路的作用，可为防治GIOP提供有力依据，为中医药治疗GIOP提供新方向。
Abstract:
By reviewing the connections between Wnt/β-catenin signaling pathway and glucocorticoid induced osteoporosis (GIOP), and the researches on the treatment of GIOP with herbal monomers and herbal compounds intervention on Wnt/β-catenin signaling pathway, it is found that the inhibition of Wnt/β-catenin signaling pathway is related to the occurrence and development of GIOP; herbal monomers and herbal compounds could activate Wnt/β-catenin signaling pathway again by regulating the expressions of the inhibitors of Wnt/β-catenin signaling pathway including DKK1, CTSK, WIFI, GSK3β, SOST, thereby preventing and treating GIOP. Therefore, the exploration into the effects of TCM on Wnt/β-catenin signaling pathway could provide the powerful reference for the prevention and the treatment of GIOP and the new direction for TCM therapy of GIOP.

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备注/Memo

备注/Memo:
史凡凡（1994—），男，硕士学位。研究方向：脊柱相关疾病的中医药防治。国家自然科学基金（81760877）；甘肃省自然科学基金（17JR5RA051）；甘肃省中医药管理局科研课题（GZK-2018-35，GZK-2019-2）；兰州市创新人才项目（2018-RC-99）；兰州市科技局科研课题（2019-ZD-116）；甘肃中医药大学研究生创新基金项目（CS2018-10）。
更新日期/Last Update: 2024-03-15