[1]李莉,邵琴,陈洁.散结镇痛胶囊联合醋酸甲羟孕酮对子宫腺肌病腹腔镜子宫切除术后患者的影响[J].西部中医药,2025,38(05):147-150.[doi:10.12174/j.issn.2096-9600.2025.05.28]
　LI Li,SHAO Qin,CHEN Jie.Effects of Nodulus-eliminating Pain-relieving Capsules Combined with Medroxyprogesterone Acetate on Patients with Adenomyosis After Laparoscopic Hysterectomy[J].Western Journal of Traditional Chinese Medicine,2025,38(05):147-150.[doi:10.12174/j.issn.2096-9600.2025.05.28]
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散结镇痛胶囊联合醋酸甲羟孕酮对子宫腺肌病腹腔镜子宫切除术后患者的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年05期
页码:
147-150
栏目:
衷中参西
出版日期:
2025-05-15

文章信息/Info

Title:
Effects of Nodulus-eliminating Pain-relieving Capsules Combined with Medroxyprogesterone Acetate on Patients with Adenomyosis After Laparoscopic Hysterectomy
作者:
李莉, 邵琴, 陈洁
宁国市人民医院妇产科，安徽 宁国 242300
Author(s):
LI Li, SHAO Qin, CHEN Jie
Department of Obstetrics and Gynecology, Ningguo County People’s Hospital, Ningguo 242300, China
关键词:
子宫腺肌病; 腹腔镜术; 雌二醇; 血清癌抗原125; 散结镇痛胶囊; 醋酸甲羟孕酮
Keywords:
adenomyosis; laparoscopic surgery; estradiol; CA125; nodulus-eliminating pain-relieving capsules; medroxyprogesterone acetate
分类号:
R271.9
DOI:
10.12174/j.issn.2096-9600.2025.05.28
文献标志码:
B
摘要:
目的探讨散结镇痛胶囊联合醋酸甲羟孕酮对子宫腺肌病腹腔镜子宫切除术后患者的影响。 方法选取宁国市人民医院妇产科收治的行腹腔镜手术治疗的子宫腺肌病患者90例，随机分为对照组和联合组，每组45例。对照组术后予醋酸甲羟孕酮治疗，联合组术后予散结镇痛胶囊联合醋酸甲羟孕酮治疗，比较两组患者临床疗效、血清指标、炎症因子、性激素水平及不良反应发生率。 结果联合组总有效率为93.33%（42/45），高于对照组的77.78%（35/45）（P＜0.05）。治疗后两组患者血清糖类抗原125（carbohydrate antigen 125，CA125）、CA199、人附睾蛋白4（human epididymis protein 4，HE4）、雌二醇（estradiol，E2）、促黄体生成素（luteinizing hormone，LH）、卵泡刺激素（follicle-stimulating hormone，FSH）、超敏C反应蛋白（high-sensitivity C-reactive protein，hs-CRP）、肿瘤坏死因子α（tumor necrosis factor α，TNF-α）、白细胞介素6（interleukin-6，IL-6）均降低（P＜0.05），且联合组低于对照组（P＜0.05）。不良反应发生率联合组为11.11%（5/45），对照组为8.89%（4/45），两组比较差异无统计学意义（χ2=0.123，P=0.725）。 结论散结镇痛胶囊联合醋酸甲羟孕酮可改善子宫腺肌病腹腔镜子宫切除术后患者的血清指标及性激素水平，减轻患者炎症反应，疗效确切且安全性较高。
Abstract:
ObjectiveTo explore the influence of nodulus-eliminating pain-relieving capsules and medroxy-progesterone acetate on patients with adenomyosis after laparoscopic hysterectomy. MethodsAll 90 patients with adenomyosis, who were admitted to department of obstetrics and gynecology, Ningguo county people’s hospital, were chosen and randomized into the control group and the combination group with 45 cases in each group. The control group was treated with medroxyprogesterone acetate after the operation, and the combination group orally took nodulus-eliminating pain-relieving capsules and medroxyprogesterone acetate after the surgery, to compare clinical effects, serum markers, the levels of inflammatory factors and sex hormone, and the incidences of adverse reactions between both groups. ResultsTotal effective rate of the combination group was 93.33% (42/45), higher than 77.78% (35/45) of the control group (P<0.05). After the treatment, the levels of CA125, CA199, HE4, E2, LH, FSH, hs-CRP, TNF-α and IL-6 were lowered (P<0.05), and the combination group was lower than the control group (P<0.05). The incidence of adverse reaction of the combination group was 11.11%(5/45), higher than 8.89%(4/45) of the control group, and the difference had no statistical meaning between both groups (χ2=0.123, P=0.725). ConclusionNodulus-eliminating pain-relieving capsules and medroxyprogesterone acetate could improve the levels of serum markers and sex hormone in patients with adenomyosis after laparoscopic hysterectomy and alleviate the patients’ inflammatory reaction with definite clinical effects and higher safety.

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备注/Memo

备注/Memo:
李莉（1979—），女，主任医师。研究方向：妇产科疾病的诊治。Email：nglili@163.com。
更新日期/Last Update: 2025-05-15