[1]王强,刘皎茹,马莉娉,等.红景天治疗抑郁症有效性及安全性Meta分析[J].西部中医药,2025,38(06):86-89.[doi:10.12174/j.issn.2096-9600.2025.06.16]
　WANG Qiang,LIU Jiaoru,MA Lipin,et al.Meta-analysis of the Effectiveness and Safety of Hongjingtian in the Treatment of Depression[J].Western Journal of Traditional Chinese Medicine,2025,38(06):86-89.[doi:10.12174/j.issn.2096-9600.2025.06.16]
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红景天治疗抑郁症有效性及安全性Meta分析()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年06期
页码:
86-89
栏目:
二次研究
出版日期:
2025-06-15

文章信息/Info

Title:
Meta-analysis of the Effectiveness and Safety of Hongjingtian in the Treatment of Depression
作者:
王强, 刘皎茹, 马莉娉, 赵玉荣, 杨文珂, 马雪曼
青海大学医学部，青海 西宁 810016
Author(s):
WANG Qiang, LIU Jiaoru, MA Lipin, ZHAO Yurong, YANG Wenke, MA Xueman
关键词:
抑郁症; 中医药; 红景天; Meta分析
Keywords:
depression; TCM; Meta-analysis
分类号:
R256.29
DOI:
10.12174/j.issn.2096-9600.2025.06.16
文献标志码:
A
摘要:
目的系统评价红景天治疗抑郁症的有效性及安全性。 方法计算机检索Cochrane Library，Pubmed和Embase英文数据库，中国期刊全文数据库（CNKI）、万方中文数据库中红景天治疗抑郁症的所有临床随机对照试验，检索时间范围限定为建库至2022年3月。由两位研究者对纳入文献独立进行数据提取，运用Rev Man 5.4软件进行Meta分析。 结果最终纳入3篇文献，共360例患者，其中试验组230例，对照组130例。试验组在降低抑郁症患者汉密尔顿抑郁量表（Hamilton depression scale，HAMD）评分（MD=-6.21，95%CI：-10.22～-2.20，P=0.002）和贝克抑郁量表（Beck depression inventory，BDI）评分（MD=-8.61，95%CI：-15.22～-1.99，P=0.01）方面均优于对照组。两组患者在普通及严重不良事件发生率方面差异无统计学意义。亚组分析显示，高剂量红景天组患者BDI评分降低幅度（MD=-2.22，95%CI：-2.89～-1.56，P＜0.000 01）大于低剂量组。 结论红景天可有效治疗抑郁症，且安全性良好。
Abstract:
ObjectiveTo systematically evaluate the effectiveness and safety of Hongjingtian (Rhodiolae crenulatae radix et rhizoma) in the treatment of depression. MethodsAll clinical randomized controlled trials (RCTs) on the treatment of depression with Hongjingtian were searched from Cochrane Library, Pubmed, Embase databases, CNKI and Wanfang, and the retrieval time was between the time of establishing the database and March, 2022. Data was extracted from the included literature by two researchers independently, and Meta analysis was performed using Rev Man 5.4 software. ResultsConsequently, three papers were included, involving 360 patients, among them, there were 230 cases in the experiment group and 130 cases in the control group. The experiment group was better than the control group in reducing depression patients’ HAMD scores (MD=-6.21, 95%CI:-10.22 - -2.20, P=0.002) and BDI scores (MD=-8.61, 95%CI:-15.22 - -1.99, P=0.01). The difference had no statistical meaning in the incidences of common and serious adverse events between both groups. Subgroup analysis displayed that the decrease (MD=-2.22, 95%CI:-2.89 - -1.56, P<0.000 01) of BDI in high dose group of Hongjingtian was greater than that of low dose group. Conclusion Hongjingtian could effectively treat depression with good safety.

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备注/Memo

备注/Memo:
王强（1996—），女，在读博士研究生。研究方向：中医药抗肿瘤。青海省自然科学基金（2020-ZJ-949Q）。
更新日期/Last Update: 2025-06-15