[1]张健,杨东霞,王硕琪,等.少腹逐瘀汤加减联合西药治疗子宫内膜异位症的Meta分析[J].西部中医药,2025,38(08):59-65.[doi:10.12174/j.issn.2096-9600.2025.08.12]
　ZHANG Jian,YANG Dongxia,WANG Shuoqi,et al.Meta-analysis of the Treatment of Endometriosis by Modified Shaofu Zhuyu Decoction and Western Medicine[J].Western Journal of Traditional Chinese Medicine,2025,38(08):59-65.[doi:10.12174/j.issn.2096-9600.2025.08.12]
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少腹逐瘀汤加减联合西药治疗子宫内膜异位症的Meta分析
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年08期
页码:
59-65
栏目:
二次研究
出版日期:
2025-08-15

文章信息/Info

Title:
Meta-analysis of the Treatment of Endometriosis by Modified Shaofu Zhuyu Decoction and Western Medicine
作者:
张健1, 杨东霞2, 王硕琪1, 李富震1, 李晓霖1, 常铭熙1, 张福利1
1.黑龙江中医药大学，黑龙江 哈尔滨 150040
2.黑龙江中医药大学附属第二医院，黑龙江 哈尔滨 150001
Author(s):
ZHANG Jian1, YANG Dongxia2, WANG Shuoqi1, LI Fuzhen1, LI Xiaolin1, CHANG Mingxi1, ZHANG Fuli1
1.Heilongjiang University of Chinese Medicine, Harbin 150040, China
2.The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, China
关键词:
子宫内膜异位症; 少腹逐瘀汤; Meta分析; 随机对照试验
Keywords:
endometriosis; decoction; Meta-analysis; randomized controlled trials
分类号:
R271.11
DOI:
10.12174/j.issn.2096-9600.2025.08.12
文献标志码:
A
摘要:
目的系统评价少腹逐瘀汤加减联合西药治疗子宫内膜异位症（endometriosis，EMS）的有效性和安全性。 方法检索建库至2022年3月1日期间中国知网、维普、万方、CBM、PubMed、EMbase、Cochrane Library数据库中少腹逐瘀汤治疗EMS的相关研究，使用RevMan 5.4软件进行Meta分析。 结果共纳入研究文献17篇，患者1514例，Meta分析结果显示：与单纯常规西药治疗组相比，中西医结合治疗组可提高临床有效率（RR=1.18，95%CI：1.13～1.23，P＜0.000 01）、妊娠率（RR=1.83，95%CI：1.33～2.54，P＜0.05），降低EMS复发率（RR=0.25，95%CI：0.16～0.41，P＜0.000 01）、促黄体生成素水平（MD=-0.72，95%CI：-1.10～-0.35，P＜0.05）、雌二醇水平（MD=-28.35，95%CI：-41.21～-15.49，P＜0.000 1）、CA125水平（SMD=-1.71，95%CI：-2.49～-0.93，P＜0.000 1）、痛经程度VAS评分（MD=-0.50，95%CI：-0.57～-0.44，P＜0.000 01）以及不良反应发生率（RR=0.39，95%CI：0.23～0.65，P＜0.05），在降低促卵泡生成素水平方面，中西医结合治疗组与单纯常规西药治疗组相比差异无统计学意义（MD=-1.04，95%CI：-2.25～0.16，P=0.09）。 结论少腹逐瘀汤加减联合西药治疗EMS与单纯使用西药相比，可提高临床有效率、提高妊娠率，降低EMS复发率、促黄体生成素、雌二醇、CA125水平、痛经程度VAS评分以及减少不良反应发生率。
Abstract:
ObjectiveTo systematically assess the effectiveness and safety of modified Shaofu Zhuyu decoction and Western medicine in the treatment of endometriosis (EMS). MethodsThe relevant studies on treating EMS with Shaofu Zhuyu decoction were retrieved from CNKI, VIP, Wanfang, CBM, PubMed, EMbase and Cochrane Library between the time of establishing the database to March 1st, 2022, RevMan 5.4 was used to conduct Meta analysis. ResultsAll 17 papers and 1514 patients were included, the results of Meta analysis displayed that: compared with the treatment group of single conventional Western medicine, the treatment group of integrative medicine could lift clinical effective rate (RR=1.18, 95%CI:1.13-1.23, P<0.000 01), pregnancy rate (RR=1.83, 95%CI:1.33-2.54, P<0.05), lower the recurrence rate of EMS (RR=0.25, 95%CI:0.16-0.41, P<0.000 01), the levels of luteinizing hormone (LH) (MD=-0.72, 95%CI:-1.10--0.35, P<0.05), estradiol (MD=-28.35, 95%CI:-41.21--15.49, P<0.000 1), and the levels of CA125 (SMD=-1.71, 95%CI:-2.49--0.93, P<0.000 1), and the VAS scores of dysmenorrhea (MD=-0.50, 95%CI:-0.57--0.44, P<0.000 01) and the incidence of adverse reaction (RR=0.39, 95%CI:0.23-0.65, P<0.05), the difference had no statistical meaning in reducing the levels of follicle-stimulating hormone between the treatment group of integrative medicine and the treatment group of conventional Western medicine (MD=-1.04, 95%CI:-2.25--0.16, P=0.09). ConclusionCompared with single use of Western medicine, modified Shaofu Zhuyu decoction and Western medicine could improve clinical effective rate and pregnancy rate, lower EMS recurrence rate, the levels of LH, estradiol, CA125, VAS scores of dysmenorrhea, and the incidences of adverse reaction in the treatment of EMS.

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备注/Memo

备注/Memo:
张健（1995—），女，在读博士研究生。研究方向：温病学理法方药的临床与实验研究。国家自然科学基金（81574015）；中央支持地方高校改革发展资金人才培养项目；黑龙江省自然科学基金（LH2020H087）；黑龙江省中医药科研项目（ZHY2020-80）。
更新日期/Last Update: 2025-08-15