[1]陈琦,王虹,朱伟,等.针刺髓海联合重复经颅磁刺激治疗轻中度血管性痴呆临床研究[J].西部中医药,2025,38(10):134-137.[doi:10.12174/j.issn.2096-9600.2025.10.24]
　CHEN Qi,WANG Hong,ZHU Wei,et al.Clinical Study on the Combination of Needling Marrow Sea and Repetitive Transcranial Magnetic Stimulation in Treating Mild to Moderate Vascular Dementia[J].Western Journal of Traditional Chinese Medicine,2025,38(10):134-137.[doi:10.12174/j.issn.2096-9600.2025.10.24]
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针刺髓海联合重复经颅磁刺激治疗轻中度血管性痴呆临床研究()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年10期
页码:
134-137
栏目:
特色医疗
出版日期:
2025-10-15

文章信息/Info

Title:
Clinical Study on the Combination of Needling Marrow Sea and Repetitive Transcranial Magnetic Stimulation in Treating Mild to Moderate Vascular Dementia
作者:
陈琦, 王虹, 朱伟, 马雪峰, 吴金仓, 张静静
亳州市中医院，安徽 亳州 236800
Author(s):
CHEN Qi, WANG Hong, ZHU Wei, MA Xuefeng, WU Jincang, ZHANG Jingjing
Bozhou Hospital of Traditional Chinese Medicine, Bozhou 236818, China
关键词:
血管性痴呆; 髓海; 重复经颅磁刺激; 针刺
Keywords:
vascular dementia; marrow sea; rTMS; acupuncture
分类号:
R259
DOI:
10.12174/j.issn.2096-9600.2025.10.24
文献标志码:
B
摘要:
目的观察针刺髓海联合重复经颅磁刺激（repetitive transcranial magnetic stimulation，rTMS）对轻中度血管性痴呆（vascular dementia，VD）患者的临床疗效。 方法将68例轻中度VD患者按照随机数字表法分为对照组和观察组，每组34例。两组均根据痴呆诊疗指南行常规疗法，对照组予盐酸多奈哌齐片治疗，观察组在对照组治疗基础上予针刺髓海联合rTMS治疗，两组均连续治疗12周。比较两组患者认知能力简易精神状态（mini-mental state examination，MMSE）、长谷川智能量表（revised Hasegawa?s dementia scale，HDS-R）评分、日常生活能力（activities of daily living，ADL）评分、临床疗效及不良反应。 结果治疗12周后两组患者MMSE与HDS-R评分均增加（P＜0.05），且观察组增加程度优于对照组（P＜0.05）；治疗6周及12周，两组患者ADL评分均增加（P＜0.05），且观察组较同时间点对照组增加更显著（P＜0.05）；治疗12周总有效率观察组［88.24%（30/34）］高于对照组［64.71%（22/34）］（P＜0.05）；两组治疗期间不良反应发生率比较差异无统计学意义（P＞0.05）。 结论针刺髓海联合rTMS能改善轻中度VD患者的认知功能，提高日常生活能力。
Abstract:
Objective: To survey curative effects of needling marrow sea and rTMS in the treatment of mild to moderate VD. MethodsA total of 68 patients were allocated to the control group (n=34) and the observation group (n=34). Conventional therapy was administered to the two groups per the diagnostic guidelines for dementia, the control group was administered Donepezil Hydrochloride tablets orally, and the observation group received needling marrow sea and rTMS, and both groups were treated for 12 weeks in a row. To compare MMSE, HDS-R scores, ADL scores, curative effects and adverse reaction between the two groups. ResultsAfter 12 weeks of the treatment, MMSE and HDS-R scores increased in the two groups (P<0.05), amd the increase of the observation group was better than that of the control group (P<0.05); after 6 weeks and 12 weeks of the treatment, the increase of ADL scores could be found in the two groups (P<0.05), and the increase was greater in the observation group than in the control group at the same time point (P<0.05); total effective rate of the observation group was [88.24%(30/34)], higher than [64.71%(22/34)] of the control group (P<0.05); The difference was insignificant in the comparisons of the incidences of adverse reaction during therapeutic period between both groups (P>0.05). ConclusionNeedling marrow sea and rTMS could improve the patients’ cognitive function and ADL.

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备注/Memo

备注/Memo:
陈琦（1988—），男，主治中医师。研究方向：针灸康复。Email：1049585465@qq.com。上海市卫生健康委员会科研项目（202140160）。 2022年度安徽省中医药传承创新科研项目计划（2022CCCD07）。
更新日期/Last Update: 2025-10-15