[1]张慧君.柴胡桂枝干姜汤治疗肝郁脾虚型胃食管反流病临床观察[J].西部中医药,2025,38(11):122-125.[doi:10.12174/j.issn.2096-9600.2025.11.21]
　ZHANG Huijun.Clinical Observation on Chaihu Guizhi Dried Ginger Decoction in the Treatment of Gastroesophageal Reflux Disease of Liver Depression and Spleen Deficiency Pattern[J].Western Journal of Traditional Chinese Medicine,2025,38(11):122-125.[doi:10.12174/j.issn.2096-9600.2025.11.21]
点击复制

柴胡桂枝干姜汤治疗肝郁脾虚型胃食管反流病临床观察()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年11期
页码:
122-125
栏目:
衷中参西
出版日期:
2025-11-15

文章信息/Info

Title:
Clinical Observation on Chaihu Guizhi Dried Ginger Decoction in the Treatment of Gastroesophageal Reflux Disease of Liver Depression and Spleen Deficiency Pattern
作者:
张慧君
甘肃省中医院，甘肃 兰州 730050
Author(s):
ZHANG Huijun
Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
关键词:
胃食管反流病; 肝郁脾虚; 柴胡桂枝干姜汤; 临床疗效; 生活质量; 胃激素
Keywords:
gastroesophageal reflux disease; liver depression and spleen deficiency; dried ginger decoction; clinical effects; quality of life; gastric hormone
分类号:
R256.3
DOI:
10.12174/j.issn.2096-9600.2025.11.21
文献标志码:
B
摘要:
目的观察柴胡桂枝干姜汤治疗肝郁脾虚型胃食管反流病的临床疗效。 方法按照就诊顺序将80例肝郁脾虚型胃食管反流病患者随机分为观察组与对照组，每组40例。对照组采用莫沙必利、雷贝拉唑等西药常规治疗，观察组在对照组治疗基础上联合柴胡桂枝干姜汤加减治疗。两组均于连续治疗4周后观察中医证候积分、生活质量评分及胃激素水平（血浆胃动素、血清胃泌素）的变化情况并观察临床疗效。 结果观察组痊愈率为37.50%（15/40）、总有效率为97.50%（39/40），对照组痊愈率为25.00%（10/40）、总有效率为87.50%（35/40），两组比较差异有统计学意义（P＜0.05）。胸痛、反酸、烧心、胃痛、嘈杂、嗳气、恶心等中医证候积分治疗前两组间比较，差异无统计学意义（P＞0.05）；治疗后两组均下降，且观察组下降更明显，差异有统计学意义（P＜0.05）。生活质量评分治疗前两组间比较，差异无统计学意义（P＞0.05）；治疗后均有所上升，且观察组上升更明显，差异有统计学意义（P＜0.05）。血浆胃动素、血清胃泌素水平治疗前两组间比较，差异无统计学意义（P＞0.05）；治疗后两组均有所上升，且观察组上升更明显，差异有统计学意义（P＜0.05）。 结论在西药常规治疗基础上联合柴胡桂枝干姜汤治疗肝郁脾虚型胃食管反流病，临床疗效较好，可有效调节胃激素水平，减轻患者临床症状，提高生活质量。
Abstract:
ObjectiveTo observe therapeutic effects of Chaihu Guizhi dried ginger decoction in the treatment of gastroesophageal reflux disease (GERD) of liver depression and spleen deficiency pattern. MethodsEighty patients were randomized into the observation group and the control group with 40 cases in each according to the sequence of visits. The control group received conventional therapy of Western medicine including mosapride and rabeprazole, while Chaihu Guizhi dried ginger decoction was given to the observation group on the basis of the therapy of the control group. To observe TCM syndrome scores, the scores of quality of life, and the levels of gastric hormone (plasma gastrin and serum gastrin) between the two groups after four weeks of the treatment, and to survey curative effects. ResultsThe cure rate was 37.50% (15/40) and total effective rate reached 97.50% (39/40) in the observation group, while these rates in the control group were 25.00%(10/40) and 87.50% (35/40), and the difference had statistical meaning between the two groups (P<0.05). The difference was insignificant in the scores of TCM syndromes including chest pain, sour regurgitation, and heartburn, stomachache, gastric discomfort, belching, and nausea before the treatment between the two groups (P>0.05); the scores were reduced after the treatment in the two groups, and the decrease of the observation group was more evident, and the difference had statistical meaning (P<0.05). The difference had no statistical meaning in the scores of quality of life before the treatment between the two groups (P>0.05); the increase was found after the treatment, and the increase of the observation group was more noticeable, and the difference was statistically significant (P<0.05). The difference showed no statistical meaning in the levels of plasma gastrin and serum gastrin before the treatment between the two groups (P>0.05); after the treatment, the elevation was seen in the two groups, and the increase of the observation group was more remarkable, and the difference had statistical meaning (P<0.05). ConclusionOn the foundation of conventional therapy of Western medicine, its combined use with the decoction yields superior clinical outcomes in GERD management, which could effectively adjust the levels of gastric hormone, relieve the patients’ clinical symptoms and improve quality of life.

相似文献/References:

[1]杨建新,王春晓,胡晓兰.运用“胸痹”理论治疗胃食管反流病经验[J].西部中医药,2015,28(11):94.
[2]梁胜斌,杨世洁,李共信,等.敦煌葆元汤治疗肝郁脾虚型肠易激综合征的临床观察[J].西部中医药,2013,26(07):79.
　LIANG Shengbin,YANG Shijie,LI Gongxin,et al.Clinical Observation on DunHuang BaoYuanTang in Treating Irrirable Bowel Syndrome of Liver Qi Stagnation and Spleen Deficiency Pattern[J].Western Journal of Traditional Chinese Medicine,2013,26(11):79.
[3]牛晓玲,孙志广△,颜翠红,等.泻火降逆汤对胃食管反流患者胃肠激素的影响及临床观察[J].西部中医药,2018,31(02):82.
　NIU Xiaoling,SUN Zhiguang,YAN Cuihong,et al.Clinical Observation and the Influence of XieHuo JiangNi Decoction on Gastrointestinal Hormone of Gastroesophageal Reflux Disease[J].Western Journal of Traditional Chinese Medicine,2018,31(11):82.
[4]马国珍,舒劲,王煜,等.运脾颗粒对功能性消化不良大鼠胃肠激素的影响[J].西部中医药,2018,31(04):20.
　MA Guozhen,SHU Jin,WANG Yu,et al.Effects of Spleen-activating Granules on Gastrointestinal Hormone of the Rats with Functional Dyspepsia[J].Western Journal of Traditional Chinese Medicine,2018,31(11):20.
[5]曲骞,吴煜△.吴煜教授疏肝健脾法治疗肝癌经验探析[J].西部中医药,2018,31(06):40.
　QU Qian,WU Yu.Analysis of Professor Wu Yu′s Experience of Treating Liver Cancer by Liver-soothing Spleen-invigorating Method[J].Western Journal of Traditional Chinese Medicine,2018,31(11):40.
[6]周晓曦.加味三香汤治疗肝郁脾虚型功能性消化不良66例[J].西部中医药,2019,32(08):76.
　ZHOU Xiaoxi.Modified Sanxiang Decoction in Treating 66 Cases of Functional Dyspepsia of Liver Depression and Spleen Deficiency Pattern[J].Western Journal of Traditional Chinese Medicine,2019,32(11):76.
[7]冯敏,马维晋.个性化干预对胃食管反流病患者生活质量的影响[J].西部中医药,2025,38(11):108.[doi:10.12174/j.issn.2096-9600.2025.11.18]
　FENG Min,MA Weijin.Effects of Individualized Intervention on Quality of Life in GERD Patients[J].Western Journal of Traditional Chinese Medicine,2025,38(11):108.[doi:10.12174/j.issn.2096-9600.2025.11.18]
[8]郭栴子,朱中博,杨硕,等.王道坤教授治疗乳腺癌化疗后失眠经验撷英[J].西部中医药,2021,34(06):38.[doi:10.12174/j.issn.2096-9600.2021.06.09]
　GUO Zhanzi,ZHU Zhongbo,YANG Shuo,et al.Professor Wang Daokun′s Experience in Treating Insomnia after Chemotherapy of Breast Cancer[J].Western Journal of Traditional Chinese Medicine,2021,34(11):38.[doi:10.12174/j.issn.2096-9600.2021.06.09]
[9]豆鹏程,代禹红.舒劲主任医师治疗胃食管反流病经验[J].西部中医药,2023,36(01):36.[doi:10.12174/j.issn.2096-9600.2023.01.09]
　DOU Pengcheng,DAI Yuhong.Chief Physician Shu Jin's Experience in Treating Gastroesophageal Reflux Disease[J].Western Journal of Traditional Chinese Medicine,2023,36(11):36.[doi:10.12174/j.issn.2096-9600.2023.01.09]
[10]张迎春,何海艳,杨欣,等.PPIs联合半夏厚朴汤治疗胃食管反流病疗效与安全性Meta分析[J].西部中医药,2023,36(01):62.[doi:10.12174/j.issn.2096-9600.2023.01.16]
　ZHANG Yingchun,HE Haiyan,YANG Xin,et al.Meta-analysis of the Efficacy and the Safety of PPIs Combined with Banxia Houpo Tang in the Treatment of Gastroesophageal Reflux Disease[J].Western Journal of Traditional Chinese Medicine,2023,36(11):62.[doi:10.12174/j.issn.2096-9600.2023.01.16]

备注/Memo

备注/Memo:
张慧君（1976—），女，硕士学位，副主任医师。研究方向：中西医结合治疗消化系统疾病。Email：huijun110@126.com。
更新日期/Last Update: 2025-11-15