[1]王浥柳,王永谦.调神醒脑针刺法联合重复经颅磁刺激治疗轻中度血管性痴呆的临床疗效[J].西部中医药,2025,38(12):153-156.[doi:10.12174/j.issn.2096-9600.2025.12.32]
　WANG Yiliu,WANG Yongqian.Clinical Effects of Mind-adjusting Consciousness-restoring Needling Combined with Repetitive Transcranial Magnetic Stimulation in the Treatment of Mild to Moderate Vascular Dementia[J].Western Journal of Traditional Chinese Medicine,2025,38(12):153-156.[doi:10.12174/j.issn.2096-9600.2025.12.32]
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调神醒脑针刺法联合重复经颅磁刺激治疗轻中度血管性痴呆的临床疗效()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年12期
页码:
153-156
栏目:
特色医疗
出版日期:
2025-12-15

文章信息/Info

Title:
Clinical Effects of Mind-adjusting Consciousness-restoring Needling Combined with Repetitive Transcranial Magnetic Stimulation in the Treatment of Mild to Moderate Vascular Dementia
作者:
王浥柳1, 王永谦2
1.上海中医药大学附属市中医医院，上海 200071
2.上海中医药大学附属龙华医院，上海 200032
Author(s):
WANG Yiliu1, WANG Yongqian2
1.Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai 200071, China
2.Longhua Hospital Shanghai University of TCM, Shanghai 200032, China
关键词:
血管性痴呆; 调神醒脑针刺法; 氧化应激; 生活质量
Keywords:
vascular dementia; mind-adjusting consciousness-restoring needling; oxidative stress; quality of life
分类号:
R246
DOI:
10.12174/j.issn.2096-9600.2025.12.32
文献标志码:
B
摘要:
目的探讨调神醒脑针刺法联合重复经颅磁刺激（repetitive transcranial magnetic stimulation，rTMS）治疗轻中度血管性痴呆（vascular dementia，VD）的临床疗效。 方法选取88例轻中度VD患者，按随机数字表法分为对照组与观察组，每组44例。两组均予常规基础干预；对照组在此基础上口服盐酸多奈哌齐片；观察组在对照组用药基础上，联合调神醒脑针刺法与rTMS治疗。两组均持续治疗3个月。比较两组治疗前后简易精神状态检查（mini-mental state examination，MMSE）评分、日常生活活动能力量表（activities of daily living，ADL）评分，血清超氧化物歧化酶（superoxide dismutase，SOD）、谷胱甘肽过氧化物酶（glutathione peroxidase，GSH-Px）、丙二醛（malondialdehyde，MDA）水平，以及临床总有效率与不良反应发生率。 结果治疗后，两组MMSE评分、ADL评分及血清SOD、GSH-Px水平均升高，血清MDA水平降低（均P＜0.05）；且观察组上述指标变化幅度均大于对照组（均P＜0.05）。观察组临床总有效率［88.64%（39/44）］高于对照组［70.45%（31/44）］（P＜0.05）；观察组不良反应发生率［4.55%（2/44）］低于对照组［6.82%（3/44）］，但两组比较差异无统计学意义（P＞0.05）。 结论调神醒脑针刺法联合rTMS治疗轻中度VD临床疗效显著，可有效改善患者认知功能，提高日常生活活动能力，减轻氧化应激损伤，并降低不良反应发生率。
Abstract:
ObjectiveTo discuss clinical effects of mind-adjusting consciousness-restoring needling combined with repetitive transcranial magnetic stimulation (rTMS) in the treatment of mild to moderate vascular dementia (VD). MethodsAll 88 cases of mild to moderate VD were chosen, and allocated to the control group and the observation group according to random number table method with 44 cases in each. Both groups accepted conventional basic intervention; the control group orally took donepezil hydrochloride tablets; and mind-adjusting consciousness-restoring needling and rTMS were administered to the observation group based on the therapy of the control group. Both groups were treated for three months in a row. To compare MMSE scores, ADL scores, the levels of serum SOD, GSH-Px and MDA, clinical total effective rate and the incidence of adverse reaction before and after the treatment between the two groups. ResultsAfter the treatment, MMSE scores, ADL scores, the levels of serum SOD, GSH-Px were elevated in the two groups, and the levels of serum MDA were lowered (all P<0.05); the changes of the above indexes in the observation group were greater than these of the control group (all P<0.05). Clinical total effective rate of the observation group was [88.64%(39/44)], higher than [70.45%(31/44)] of the control group (P<0.05); the incidence of adverse reaction of the observation group was [4.55%(2/44)], lower than [6.82%(3/44)] of the control group, but the difference showed no statistical meaning between the two groups (P>0.05). ConclusionMind-adjusting consciousness-restoring needling combined with rTMS demonstrates significant clinical efficacy in treating mild to moderate VD, it could effectively improve the patients’ cognitive function, enhance ADL, relieve oxidative stress damage and lower the incidence of adverse reaction.

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备注/Memo

备注/Memo:
上海市卫生和计划生育委员会科研课题（201840029）。王浥柳（1996—），女，硕士学位，医师。研究方向：脑血管病的中西医治疗。
更新日期/Last Update: 2025-12-15