[1]汤梦迪,丁明月.参苓白术颗粒联合西药对肠道菌群失调相关性腹泻患者临床疗效及胃肠激素的影响[J].西部中医药,2026,39(08):167-171.[doi:10.12174/j.issn.2096-9600.2026.08.31]
　TANG Mengdi,DING Mingyue.Effect of Shenling Baizhu Granules Combined with Western Medicine on Clinical Efficacy and Gastrointestinal Hormones in Patients with Intestinal Flora Imbalance-Associated Diarrhea[J].Western Journal of Traditional Chinese Medicine,2026,39(08):167-171.[doi:10.12174/j.issn.2096-9600.2026.08.31]
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参苓白术颗粒联合西药对肠道菌群失调相关性腹泻患者临床疗效及胃肠激素的影响()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
39
期数:
2026年08期
页码:
167-171
栏目:
衷中参西
出版日期:
2026-07-29

文章信息/Info

Title:
Effect of Shenling Baizhu Granules Combined with Western Medicine on Clinical Efficacy and Gastrointestinal Hormones in Patients with Intestinal Flora Imbalance-Associated Diarrhea
作者:
汤梦迪1, 丁明月2
1.中国人民解放军海军第九〇五医院/上海长征医院九〇五医院，上海 200050
2.射阳县人民医院，江苏 射阳 224300
Author(s):
TANG Mengdi1, DING Mingyue2
1.Shanghai Navy No. 905 Hospital/905 Hospital of People’s Liberation Army Navy, Shanghai 200050, China
2.Sheyang County People’s Hospital, Sheyang 224300, China
关键词:
腹泻; 参苓白术颗粒; 脾胃虚弱证; 肠道菌群失调; 胃肠激素
Keywords:
diarrhea; granules; spleen and stomach deficiency pattern; intestinal flora imbalance; gastrointestinal hormone
分类号:
R256.34
DOI:
10.12174/j.issn.2096-9600.2026.08.31
文献标志码:
B
摘要:
目的探讨参苓白术颗粒联合西医常规治疗肠道菌群失调相关性腹泻患者的临床疗效及其对胃肠激素的影响。 方法选取68例肠道菌群失调相关性腹泻患者为研究对象，采用随机数字表法分为对照组（西医常规治疗）与观察组（参苓白术颗粒联合西医常规治疗），每组34例，两组均连续治疗2周。比较两组临床疗效、胃肠激素水平、肠道菌群状况、不良反应发生情况及中医证候积分。 结果观察组临床疗效［97.06%（33/34）］优于对照组［82.35%（28/34）］（P＜0.05）。治疗后，两组生长抑素水平、双歧杆菌及乳杆菌水平均升高，胃动素、胃泌素水平、肠杆菌水平及各项中医证候积分均降低（P＜0.05），且观察组各指标改善程度大于对照组，差异均有统计学意义（P＜0.05）。两组不良反应发生率比较，差异无统计学意义（P＞0.05）。 结论参苓白术颗粒联合西医常规治疗肠道菌群失调相关性腹泻，可提升临床疗效，改善患者胃肠激素及肠道菌群水平，降低中医证候积分，且安全性良好。
Abstract:
ObjectiveTo explore the influence of Shenling Baizhu granules joined with Western medicine on clinical efficacy and gastrointestinal hormones in patients with intestinal flora imbalance-associated diarrhea. MethodsA total of 68 patients with intestinal flora imbalance-associated diarrhea were selected as the study subjects and randomly divided into a control group (conventional Western medicine treatment) and an observation group (Shenling Baizhu Granules combined with conventional Western medicine treatment) using a random number table method, with 34 cases in each group. Both groups received continuous treatment for two weeks. The two groups were compared in terms of clinical efficacy, gastrointestinal hormone levels, intestinal flora status, incidence of adverse reactions, and traditional Chinese medicine syndrome scores. ResultsThe clinical efficacy in the observation group [97.06% (33/34)] was superior to that in the control group [82.35% (28/34)] (P<0.05). After treatment, levels of somatostatin, as well as levels of Bifidobacterium and Lactobacillus, increased in both groups, while levels of motilin, gastrin, Enterobacteriaceae, and various traditional Chinese medicine syndrome scores decreased in both groups (P<0.05). The degree of improvement in each indicator was greater in the observation group than in the control group, and the differences were statistically significant (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Shenling Baizhu Granules combined with conventional Western medicine in the treatment of intestinal flora imbalance-associated diarrhea can improve clinical efficacy, regulate gastrointestinal hormone and intestinal flora levels, reduce traditional Chinese medicine syndrome scores, and demonstrate good safety.

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备注/Memo

备注/Memo:
上海市金山区医药卫生科技创新资金项目（2023WS15）。汤梦迪（1991—），女，主治医师。研究方向：肠道微生态与菌群。
更新日期/Last Update: 2026-08-15