[1]宗嬿,徐莲薇.基于HPO内分泌轴探讨中药单体有效成分治疗围绝经期失眠的研究进展[J].西部中医药,2026,39(09):112-116.[doi:10.12174/j.issn.2096-9600.2026.09.22]
　ZONG Yan,XU Lianwei.Research Progress on the Treatment of Perimenopausal Insomnia with Effective Components of Traditional Chinese Medicine Monomers Based on the HPO Endocrine Axis[J].Western Journal of Traditional Chinese Medicine,2026,39(09):112-116.[doi:10.12174/j.issn.2096-9600.2026.09.22]
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基于HPO内分泌轴探讨中药单体有效成分治疗围绝经期失眠的研究进展()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
39
期数:
2026年09期
页码:
112-116
栏目:
研究进展
出版日期:
2026-09-07

文章信息/Info

Title:
Research Progress on the Treatment of Perimenopausal Insomnia with Effective Components of Traditional Chinese Medicine Monomers Based on the HPO Endocrine Axis
作者:
宗嬿1,2, 徐莲薇2
1.上海市闵行区妇幼保健院,上海 201102
2.上海中医药大学附属龙华医院,上海 200032
Author(s):
ZONG Yan1,2, XU Lianwei2
1.Minhang District Maternal and Child Health Hospital, Shanghai 201102, China
2.Longhua Hospital Shanghai University of TCM, Shanghai 200032, China
关键词:
下丘脑-垂体-卵巢轴; 围绝经期失眠; 中药单体; 有效成分
Keywords:
hypothalamic-pituitary-ovarian axis; perimenopausal insomnia; traditional Chinese medicine monomer; active component
分类号:
R256.23
DOI:
10.12174/j.issn.2096-9600.2026.09.22
文献标志码:
A
摘要:
对中药单体有效成分治疗内分泌轴相关性围绝经期失眠机制进行文献综述，指出HPO内分泌轴失衡是导致围绝经期失眠的主要病理机制之一，调节HPO内分泌轴、恢复内分泌系统平衡是改善失眠症状并提高睡眠质量的核心关键；中药有效成分可通过对HPO内分泌轴的调节，稳定雌激素水平，减轻失眠症状，具有预防和治疗相结合、副作用小等优势，然而目前缺乏相应的总结性文献记载。
Abstract:
This paper presents a literature review on the mechanisms by which active ingredients of traditional Chinese medicine monomers treat perimenopausal insomnia associated with the hypothalamic-pituitary-ovarian (HPO) endocrine axis. It is pointed out that HPO endocrine axis imbalance is one of the major pathological mechanisms leading to perimenopausal insomnia, and that regulating the HPO endocrine axis to restore endocrine system homeostasis is the core key to improving insomnia symptoms and enhancing sleep quality. The active components of traditional Chinese medicine can stabilize estrogen levels through the regulation of the HPO endocrine axis, thereby alleviating insomnia symptoms. They offer advantages such as the combina-tion of prevention and treatment, as well as fewer side effects. However, there is currently a lack of comprehensive and systematic literature documentation on this topic.

相似文献/References:

[1]张耕源,张建春,谢娜,等.舒肝解郁胶囊对围绝经期失眠妇女血清FSH、IL-1β及5-HT的影响[J].西部中医药,2018,31(04):5.
　ZHANG Gengyuan,ZHANG Jianchun,XIE Na,et al.Effects of Liver-soothing Depression-relieving Capsules on FSH, IL-1β and 5-HT in the Serum of Female Patients with Menopausal Insomnia[J].Western Journal of Traditional Chinese Medicine,2018,31(09):5.

备注/Memo

备注/Memo:
上海市闵行区自然科学研究课题（2025MHZ126）；上海申康医院发展中心促进市级医院临床技能与临床创新能力三年行动计划项目（SHDC2020CR2050B）。宗嬿（1998—），女，医师。研究方向：中医药诊治妇科生殖内分泌疾病。
更新日期/Last Update: 2026-09-15