[1]杨巾,周雪宇,文杨萍,等.重组牛碱性成纤维细胞生长因子联合中药外用治疗头颈癌放射性皮炎临床观察[J].西部中医药,2026,39(09):146-149.[doi:10.12174/j.issn.2096-9600.2026.09.28]
　YANG Jin,ZHOU Xueyu,WEN Yangping,et al.Clinical Observation of Recombinant Bovine Basic Fibroblast Growth Factor Combined with Topical Chinese Herbal Medicine in the Treatment of Radiation Dermatitis in Head and Neck Cancer[J].Western Journal of Traditional Chinese Medicine,2026,39(09):146-149.[doi:10.12174/j.issn.2096-9600.2026.09.28]
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重组牛碱性成纤维细胞生长因子联合中药外用治疗头颈癌放射性皮炎临床观察()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
39
期数:
2026年09期
页码:
146-149
栏目:
临床研究
出版日期:
2026-09-07

文章信息/Info

Title:
Clinical Observation of Recombinant Bovine Basic Fibroblast Growth Factor Combined with Topical Chinese Herbal Medicine in the Treatment of Radiation Dermatitis in Head and Neck Cancer
作者:
杨巾1,2, 周雪宇2, 文杨萍2, 李坤2, 彭明尧2, 曹炯睿1,2
1.川北医学院，四川 南充 637100
2.攀枝花市中心医院，四川 攀枝花 617000
Author(s):
YANG Jin1,2, ZHOU Xueyu2, WEN Yangping2, LI Kun2, PENG Mingyao2, CAO Jiongrui1,2
1.North Sichuan Medical University, Nanchong 637100, China
2.Panzhihua Central Hospital, Panzhihua 617000, China
关键词:
头颈癌; 放射性皮炎; 重组牛碱性成纤维细胞生长因子; 中药; 疼痛数字评分法; 放射性皮炎反应评估量表
Keywords:
head and neck cancer; radiation dermatitis; recombinant bovine basic fibroblast growth factor; Chinese herbal medicine; Numerical Rating Scale; Radiation Dermatitis Reaction Assessment Scale
分类号:
R262
DOI:
10.12174/j.issn.2096-9600.2026.09.28
文献标志码:
B
摘要:
目的观察重组牛碱性成纤维细胞生长因子联合中药外用治疗头颈癌放射性皮炎的临床疗效。 方法将收治的90例头颈癌放射性皮炎患者根据随机数字表法分为对照组和试验组各45例。对照组给予常规干预，试验组在对照组基础上加用重组牛碱性成纤维细胞生长因子联合中药外用治疗，对比两组患者皮肤损伤情况、皮肤愈合时间、疼痛情况、中医证候积分与放射性皮炎反应情况。 结果两组患者治疗后皮肤损伤分级情况差异有统计学意义（P＜0.05），试验组达到0级患者例数多于对照组；试验组皮肤愈合时间短于对照组（P＜0.05），两组患者治疗后疼痛数字评分法评分、中医证候积分与放射性皮炎反应评估量表评分均下降（P＜0.05），试验组低于对照组（P＜0.05）。 结论重组牛碱性成纤维细胞生长因子联合中药外用方案可有效改善头颈部放射性皮炎患者皮肤损伤情况，缩短皮肤愈合时间，缓解疼痛，降低中医证候积分与放射性皮炎反应。
Abstract:
ObjectiveTo observe the clinical efficacy of recombinant bovine basic fibroblast growth factor combined with topical Chinese herbal medicine in the treatment of radiation dermatitis in head and neck cancer. MethodsA total of 90 patients with radiation dermatitis induced by head and neck cancer were enrolled and randomly divided into a control group and an experimental group using the random number table method, with 45 cases in each group. The control group received routine intervention, while the experimental group was treated with recombinant bovine basic fibroblast growth factor combined with topical Chinese herbal medicine in addition to the routine intervention. The two groups were compared in terms of skin injury severity, skin healing time, pain status, TCM syndrome scores, and radiation dermatitis reactions. ResultsThere was a statistically significant difference in the distribution of skin injury grades between the two groups after treatment (P<0.05), with more patients achieving grade 0 in the experimental group than in the control group. The skin healing time in the experimental group was significantly shorter than that in the control group (P<0.05). After treatment, both groups showed significant reductions in Numerical Rating Scale (NRS) scores, TCM syndrome scores, and Radiation Dermatitis Reaction Assessment Scale scores (all P<0.05), and the experimental group had significantly lower scores than the control group in all these measures (P<0.05). ConclusionThe combined regimen of recombinant bovine basic fibroblast growth factor and topical Chinese herbal medicine can effectively improve skin injury, shorten skin healing time, alleviate pain, and reduce TCM syndrome scores and radiation dermatitis reactions in patients with radiation dermatitis of the head and neck.

备注/Memo

备注/Memo:
四川省中医药管理局科学技术研究专项课题（2021MS174）；云南省地方本科高校基础研究联合专项基金项目（202101AO070205）；四川省医学科技创新研究会“医创之巅”专项研究项目（2025YCZD206）。杨巾（1989—），女，硕士学位，主治医师。研究方向：头颈部肿瘤的临床研究。
更新日期/Last Update: 2026-09-15