[1]檀盛,邓强,李建花,等.建立椎间盘退变动物模型的研究进展[J].西部中医药,2024,37(07):103-107.[doi:10.12174/j.issn.2096-9600.2024.07.24]
　TAN Sheng,DENG Qiang,LI Jianhua,et al.Research Progress in Establishing Animal Models of Intervertebral Disc Degeneration[J].Western Journal of Traditional Chinese Medicine,2024,37(07):103-107.[doi:10.12174/j.issn.2096-9600.2024.07.24]
点击复制

建立椎间盘退变动物模型的研究进展
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年07期
页码:
103-107
栏目:
研究进展
出版日期:
2024-07-15

文章信息/Info

Title:
Research Progress in Establishing Animal Models of Intervertebral Disc Degeneration
作者:
檀盛1, 邓强2, 李建花1, 张彦军2, 王鹏2, 郭铁峰2, 罗林钊2, 马平怡1, 杜磊1, 姚兴璋1
1.甘肃省中医院，甘肃 兰州 730050
2.甘肃中医药大学，甘肃 兰州 730030
Author(s):
TAN Sheng1, DENG Qiang2, LI Jianhua1, ZHANG Yanjun2, WANG Peng2, GUO Tiefeng2, LUO Linzhao2, MA Pingyi1, DU Lei1, YAO Xingzhang1
1.Gansu University of Traditional Chinese Medicine, Lanzhou 730050, China
2.Gansu University of Chinese Medicine, Lanzhou 730030, China
关键词:
椎间盘退变; 动物模型; 造模方法
Keywords:
intervertebral disc degeneration; animal models; modelling method
分类号:
R681.5+3
DOI:
10.12174/j.issn.2096-9600.2024.07.24
文献标志码:
A
摘要:
通过分析文献，发现目前常用的腰椎间盘退变（Intervertebral disc degeneration，IDD）动物模型的建立方法包括自体髓核移植法、等离子消融术、基因敲除法及机械损伤法。这些方法能够模拟人类IDD的病理生理过程，为研究疾病机制和新的治疗方法提供了有力支持。但目前的动物模型仍存在许多局限性，如模型建立难度大、费时费力、缺乏长期随访等。未来应改进现有模型，提高其仿真度和可重复性，寻找更准确的疾病模拟方法。同时，还需要开展更多关于IDD发病机制和治疗的基础研究，为临床治疗提供更有效的指导。
Abstract:
At present, the commonly-used methods of establishing animal models of intervertebral disc degeneration cover autologous nucleus pulposus transplantation, plasma ablation, gene knockout, and mechanical injury through literature analysis. These methods could simulate the pathological and physiological processes of human intervertebral disc degeneration, which could produce the powerful support for the study on the mechanism of disease and the exploration of new therapeutic methods. However, there are still many limitations in current animal models, such as the difficulty of model establishment, time-consuming and labor-intensive, and the lack of long-term follow-up. The existing models should be improved in the future to raise their simulation and repro-ducibility, and find out more accurate methods to simulate diseases. Meanwhile, more basic researches on the pathogenesis and treatment of lumbar disc degeneration are needed to provide more effective guidance for clinical treatment.

相似文献/References:

[1]甘雨,马进△,袁媛,等.线栓法制备SD大鼠局灶性脑缺血再灌注模型的实践与评价[J].西部中医药,2018,31(07):12.
　GAN Yu,MA Jin,YUAN Yuan,et al.Practice and Evaluation of Focal Cerebral Ischemia Reperfusion Rat Model Prepared by Middle Cerebral Artery Occlusion[J].Western Journal of Traditional Chinese Medicine,2018,31(07):12.
[2]蒙帅杰,蒋越,王权胜,等.补肾活血类中药对少弱精子症模型生殖激素水平干预研究的系统评价?[J].西部中医药,2021,34(11):94.[doi:10.12174/j.issn.2096-9600.2021.11.20]
　MENG Shuaijie,JIANG Yue,WANG Quansheng,et al.Systematic Evaluation on the Intervention of Kidney-tonifying Blood-activating Herbs on Reproductive Hormone Levels in Oligoasthenospermia Model[J].Western Journal of Traditional Chinese Medicine,2021,34(07):94.[doi:10.12174/j.issn.2096-9600.2021.11.20]
[3]陈丹丹,董博,欧国峰,等.抗疏强骨颗粒对去卵巢模型大鼠血清ALP及TRACP5b的影响[J].西部中医药,2021,34(05):22.[doi:10.12174/j.issn.2096-9600.2021.05.06]
　CHEN Dandan,DONG Bo,OU Guofeng,et al.Influence of Anti-osteoporosis Strengthening Bone Granules on Serum ALP and TRACP5b in Ovariectomized Rats[J].Western Journal of Traditional Chinese Medicine,2021,34(07):22.[doi:10.12174/j.issn.2096-9600.2021.05.06]
[4]高国莉.针刀对肌性斜颈模型兔胸锁乳突肌中calpain-1、CD45、MMP-2、TIMP-2蛋白表达的影响[J].西部中医药,2024,37(04):13.[doi:10.12174/j.issn.2096-9600.2024.04.03]
　GAO Guoli.Influence of Needle-knife on the Expressions of calpain-1, CD45, MMP-2 and TIMP-2 Protein in Cleidomastoid of CMT Rabbit Models[J].Western Journal of Traditional Chinese Medicine,2024,37(07):13.[doi:10.12174/j.issn.2096-9600.2024.04.03]
[5]张文瑞,杨爽,吕新亮.类风湿关节炎中医实验动物模型研究进展[J].西部中医药,2024,37(04):106.[doi:10.12174/j.issn.2096-9600.2024.04.21]
　ZHANG Wenrui,YANG Shuang,LYU Xinliang.Research Progress on Animal Model with Rheumatoid Arthritis in Traditional Chinese Medicine[J].Western Journal of Traditional Chinese Medicine,2024,37(07):106.[doi:10.12174/j.issn.2096-9600.2024.04.21]

备注/Memo

备注/Memo:
檀盛（1998—），男，在读硕士研究生。研究方向：椎间盘退变防治及治疗。国家自然科学基金地区科学基金项目（82060879）；甘肃省自然科学基金（22JR5RA624；2020-0406-JCC-0436）；甘肃省重点课题研发项目（GZKZ-2022-1）。
更新日期/Last Update: 2024-07-15