[1]李浩林,程伟刚,杨红梅,等.益气蠲痹方治疗脾失健运型膝骨关节炎性滑膜炎临床研究[J].西部中医药,2024,37(08):124-128.[doi:10.12174/j.issn.2096-9600.2024.08.28]
　LI Haolin,CHENG Weigang,YANG Hongmei,et al.Clinical Study on Benefiting-Qi Arthralgia-eliminating Decoction in the Treatment of Knee Synovitis of Dysfunction of Spleen in Transportation Pattern[J].Western Journal of Traditional Chinese Medicine,2024,37(08):124-128.[doi:10.12174/j.issn.2096-9600.2024.08.28]
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益气蠲痹方治疗脾失健运型膝骨关节炎性滑膜炎临床研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年08期
页码:
124-128
栏目:
临床研究
出版日期:
2024-08-15

文章信息/Info

Title:
Clinical Study on Benefiting-Qi Arthralgia-eliminating Decoction in the Treatment of Knee Synovitis of Dysfunction of Spleen in Transportation Pattern
作者:
李浩林1, 程伟刚1, 杨红梅1, 杨娟娟1, 李伟青2, 陈平2, 金芳梅2, 阚丽丽2, 王海东2
1.甘肃中医药大学，甘肃 兰州; 730000
2.甘肃省中医院，甘肃 兰州 730050
Author(s):
LI Haolin1, CHENG Weigang1, YANG Hongmei1, YANG Juanjuan1, LI Weiqing2, CHEN Ping2, JIN Fangmei2, KAN Lili2, WANG Haidong2
1.Gansu University of Chinese Medicine, Lanzhou 730000, China
2.Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
关键词:
骨关节炎性滑膜炎; 膝; 益气蠲痹方; 脾失健运型
Keywords:
synovitis;  knee; benefiting- arthralgia-eliminating decoction; dysfunction of spleen in transportation
分类号:
R255.6
DOI:
10.12174/j.issn.2096-9600.2024.08.28
文献标志码:
B
摘要:
目的观察益气蠲痹方治疗脾失健运型膝骨关节炎性滑膜炎（knee synovitis，KS）的临床疗效。 方法将70例患者随机分为试验组（35例，后脱落3例，纳入32例）和对照组（35例，后脱落5例，纳入30例）。对照组给予塞来昔布胶囊口服，试验组予以益气蠲痹方口服，两组连续治疗3周。评价治疗前后症状评分、视觉模拟评分法（visual analogue scale，VAS）、西安大略和麦克马斯特大学骨关节炎指数（Western Ontario and McMaster Universities Osteoarthritis Index，WOMAC）评分、膝关节肿胀程度评分等情况，评估不良反应发生情况。 结果治疗后试验组总有效率［93.75%（30/32）］高于对照组［83.33%（25/30）］（P＜0.01）；两组治疗后VAS评分、WOMAC评分及关节肿胀程度评分相比治疗前均降低（P＜0.05），且试验组下降幅度大于对照组（P＜0.05）。治疗后对照组症状总评分及关节肿胀、关节疼痛、关节活动不利及乏力等症状评分较治疗前降低（P＜0.05），但腹胀纳呆、便溏、面黄肌瘦症状评分变化不明显（P＞0.05）；试验组症状总评分及各症状评分均较治疗前降低（P＜0.05）；两组在关节活动不利症状评分的改善方面效果相当（P＞0.05），但试验组在关节肿胀、关节疼痛、腹胀纳呆、便溏、面黄肌瘦、乏力症状评分的改善方面优于对照组（P＜0.01）。 结论益气蠲痹方治疗脾失健运型KS患者，在改善患者腹胀纳呆、便溏、面黄肌瘦等伴随症状上优势明显，并且在治疗期间未出现明显不良反应。
Abstract:
ObjectiveTo observe the clinical effects of benefiting-Qi arthralgia-eliminating decoction (Yiqi Juanbi formulation) in the treatment of knee synovitis (KS) of dysfunction of spleen in transportation pattern. MethodsSeventy patients were randomized into the test group (35 cases, three cases dropped out, and 32 cases included) and the control group (35 cases, five cases dropped out, and 30 cases included). The control group took celecoxib capsules orally, and the test group accepted oral administration of the herbs, both groups were treated for three weeks continuously. To assess symptom scores, VAS, WOMAC scores, the degree of knee joint swelling before and after the treatment, and evaluate the incidence of adverse reactions. ResultsAfter the treatment, total effective rate of the test group was [93.75%(30/32)], higher than [83.33%(25/30)] of the control group (P<0.01); after the treatment, VAS scores, WOMAC scores and the degrees of knee joint swelling lowered than before the treatment (P<0.05), and the decrease of the test group was greater than that of the control group (P<0.05). After the treatment, total scores of the symptoms, joint swelling, joint pain, unfavorable joint motion and weakness reduced than before the treatment (P<0.05), while the changes in abdominal distension and anorexia, loose stool, yellow complexion and emaciated body were insignificant (P>0.05); total scores of the symptoms and the scores of different symptoms reduced than before the treatment in the test group (P<0.05); both groups were equally effective in improving the scores of unfavorable joint motion (P>0.05), but the test group was superior to the control group in improving joint swelling, joint pain, abdominal distension and anorexia, loose stool, yellow complexion and emaciated body (P<0.05). ConclusionThe prescription in the treatment of KS patients of dysfunction of spleen in transportation pattern presents the clear advantages in the improvement of the concomitant symptoms including abdominal distension and anorexia, loose stool, yellow complexion and emaciated body, and no obvious adverse reaction occur in the therapeutic period.

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备注/Memo

备注/Memo:
李浩林（1998—），男，在读博士研究生。研究方向：风湿病的中医药防治及研究。国家自然科学基金地区科学基金项目（82260880）；国家中医优势专科建设项目（甘卫中医函〔2023〕63号）；王海东甘肃省名中医传承工作室建设项目（甘卫中医函〔2022〕50号）。
更新日期/Last Update: 2024-08-15