[1]卜献忠,钟远鸣,卜保献,等.独活寄生汤治疗腰椎管狭窄症的有效性与安全性Meta分析[J].西部中医药,2024,37(10):45-50.[doi:10.12174/j.issn.2096-9600.2024.10.12]
　BU Xianzhong,ZHONG Yuanming,BU Baoxian,et al.The Effectiveness and Safety of Duhuo Jisheng Tang in the Treatment of Lumbar Spinal Stenosis: a Meta Analysis[J].Western Journal of Traditional Chinese Medicine,2024,37(10):45-50.[doi:10.12174/j.issn.2096-9600.2024.10.12]
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独活寄生汤治疗腰椎管狭窄症的有效性与安全性Meta分析
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年10期
页码:
45-50
栏目:
二次研究
出版日期:
2024-10-15

文章信息/Info

Title:
The Effectiveness and Safety of Duhuo Jisheng Tang in the Treatment of Lumbar Spinal Stenosis: a Meta Analysis
作者:
卜献忠1,2, 钟远鸣3, 卜保献4, 秦百君2, 卜若晨5, 王奕鑫4, 杨汉立2
1.河南中医药大学第一附属医院骨伤一科，河南 郑州 450000
2.广西中医药大学，广西 南宁 530001
3.广西中医药大学第一附属医院，广西 南宁 530023
4.河南省洛阳正骨医院/河南省骨科医院，河南 洛阳 471002
5.海南医学院，海南 海口 570100
Author(s):
BU Xianzhong1,2, ZHONG Yuanming3, BU Baoxian4, QIN Baijun2, BU Ruochen5, WANG Yixin4, YANG Hanli2
1.First Department of Orthopedic Traumatology, The First Affiliated Hospital of Henan University of CM, Zhengzhou 450000, China
2.Guangxi University of Chinese Medicine, Nanning 530001, China
3.The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China
4.Luoyang Orthopedic-Traumatological Hospital of Henan Province (Henan Provincial Orthopedic Hospital), Luoyang 471002, China
5.Hainan Medical University, Hainan 570100, China
关键词:
腰椎管狭窄症; 独活寄生汤; 有效性; 安全性; Meta分析
Keywords:
lumbar spinal stenosis; the effectiveness; safety; Meta analysis
分类号:
R274.9
DOI:
10.12174/j.issn.2096-9600.2024.10.12
文献标志码:
A
摘要:
目的评价独活寄生汤治疗腰椎管狭窄症（lumbar spinal stenosis，LSS）的有效性与安全性，为临床应用提供循证参考。 方法通过系统检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、PubMed、EMbase、The Cochrane library数据库有关独活寄生汤加减治疗LSS的国内外临床随机对照试验，检索时间为建库至2021年4月10日，对符合纳入标准的研究文献采用Rev Man 5.3软件进行Meta分析。 结果共纳入符合标准的文献15篇，纳入病例1314例，其中研究组659例，对照组655例；Meta分析结果显示：与对照组相比，研究组有效率（RR=1.19，95%CI：1.09～1.30，P=0.0001）、治疗后视觉模拟量表（visual analogue scale，VAS）评分（SMD=-1.03，95%CI：-1.71～-0.36，P=0.003）、日本骨科协会评估治疗分数（Japa-nese orthopedic association，JOA）评分（SMD=1.46，95%CI：0.72～2.20，P=0.0001）、Oswestry功能障碍指数问卷表（Oswestry disability index，ODI）评分（SMD=-1.23，95%CI：-1.47～-1.00，P＜0.000 01）、中医证候评分（SMD=-1.00，95%CI：-1.22～-0.78，P＜0.000 01）均优于对照组，差异均有统计学意义；两组患者不良反应发生率（RR=0.10，95%CI：0.01～1.70，P=0.11）比较，差异无统计学意义。 结论独活寄生汤加减治疗LSS具有明显优势，能够减轻患者疼痛、改善肢体功能障碍，提高患者生活质量，但安全性方面未体现出明显优势。
Abstract:
ObjectiveTo provide evidence-based reference for clinical application by evaluating the effe-ctiveness and safety of Duhuo Jisheng decoction in the treatment of lumbar spinal stenosis (LSS). MethodsClinical randomized control trials on the treatment of LSS with modified Duhuo Jisheng Tang were retrieved from CNKI, Wanfang, VIP, CBMdisc, PubMed, EMBASE and the Cochrane library database, the retrieval time ranged from the time of establishing the database to April 10, 2021, Meta analysis of the research literature that met the inclusion criteria was carried out using Rev Man 5.3 software. ResultsAll 15 papers that met the inclusion criteria, and 1314 cases have been included, among them, there were 659 cases in the study group and 655 cases in the control group; Meta analysis result displayed that the effective rate (RR=1.19, 95%CI:1.09～1.30, P=0.0001), VAS scores (SMD=-1.03, 95%CI:-1.71～ -0.36, P=0.003), and JOA scores (SMD=1.46, 95%CI:0.72～2.20, P=0.0001), ODI scores (SMD=-1.23, 95%CI:-1.47～ -1.00, P<0.000 01) and TCM syndrome integrals (SMD=-1.00, 95%CI:-1.22～-0.78, P<0.000 01) were better than these of the control group, and the difference had statistical meaning; compared with the control group, the difference had no statistical meaning in the incidences of adverse reaction (RR=0.10, 95%CI:0.01～1.70, P=0.11) between the study group and the control group. ConclusionDuhuo Jisheng Tang has the clear advantages in the treatment of LSS, it could relieve the patients' pain, improve limb dysfunction and the patients' quality of life, however, there is no clear advantage in terms of safety.

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备注/Memo

备注/Memo:
卜献忠（1989—），男，博士学位，在读博士后，助理研究员。研究方向：脊柱相关疾病的基础与临床研究。国家自然科学基金地区基金（81760874）；国家自然科学基金青年基金（82405439）；广西重点研发计划（桂科AB20159018）；河南省中医药科学研究专项课题（20-21ZY2083，2023ZXZX1003）；广西中医药大学2021年博士研究生科研创新项目（YCBXJ2021009）；河南中医药大学第一附属医院博士启动基金（KY-B0367-36）。
更新日期/Last Update: 2024-10-15