[1]白煜君,靳凡钰,王韶华,等.王氏养卵汤联合来曲唑治疗多囊卵巢综合征伴不孕症疗效观察[J].西部中医药,2024,37(10):124-129.[doi:10.12174/j.issn.2096-9600.2024.10.28]
　BAI Yujun,JIN Fanyu,WANG Shaohua,et al.Clinical Observation on Wang′s Egg-fostering Decoction Combined with Letrozole in the Treatment of Polycystic Ovarian Syndrome and Infertility[J].Western Journal of Traditional Chinese Medicine,2024,37(10):124-129.[doi:10.12174/j.issn.2096-9600.2024.10.28]
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王氏养卵汤联合来曲唑治疗多囊卵巢综合征伴不孕症疗效观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年10期
页码:
124-129
栏目:
衷中参西
出版日期:
2024-10-15

文章信息/Info

Title:
Clinical Observation on Wang′s Egg-fostering Decoction Combined with Letrozole in the Treatment of Polycystic Ovarian Syndrome and Infertility
作者:
白煜君1, 靳凡钰1, 王韶华2, 焦宁2, 张登山2
1.山东中医药大学，山东 济南 250000
2.淄博市中医医院，山东 淄博 255000
Author(s):
BAI Yujun1, JIN Fanyu1, WANG Shaohua2, JIAO Ning2, ZHANG Dengshan2
1.Shandong University of Traditional Chinese Medicine, Jinan 250000, China
2.Zibo Hospital of Traditional Chinese Medicine, Zibo 255000, China
关键词:
多囊卵巢综合征; 不孕症; 妊娠率; 性激素; 王氏养卵汤; 来曲唑
Keywords:
PCOS; infertility; pregnancy rate; sex hormone; egg-fostering decoction; letrozole
分类号:
R271.14
DOI:
10.12174/j.issn.2096-9600.2024.10.28
文献标志码:
B
摘要:
目的观察王氏养卵汤联合来曲唑治疗多囊卵巢综合征（polycystic ovarian syndrome，PCOS）伴不孕症的临床疗效。 方法将PCOS伴不孕症患者60例按随机数字表法分为对照组和观察组各30例。对照组予来曲唑治疗，观察组在对照组基础上联合王氏养卵汤治疗。比较两组患者性激素水平［促黄体生成素（luteinizing hormone，LH）、促卵泡激素（follicle stimulating hormone，FSH）、雌二醇（estradiol，E2）、泌乳素（prolactin，PRL）、睾酮（testosterone，T）］、血清空腹胰岛素（fasting insulin，FINS）、肿瘤坏死因子α（tumor necrosis factor α，TNF-α）表达水平及排卵率、妊娠率、中医证候疗效与临床总有效率。 结果治疗后，两组患者血清LH、PRL、T表达水平均低于治疗前（P＜0.05），FSH、E2表达水平高于治疗前（P＜0.05），观察组LH、PRL、T表达水平低于对照组（P＜0.05），E2表达水平高于对照组（P＜0.05）；两组患者血清FINS、TNF-α表达水平均低于治疗前（P＜0.05），观察组低于对照组（P＜0.05）；观察组排卵率为83.3%（25/30），高于对照组的50.0%（15/30）（P＜0.05）；观察组妊娠率为63.3%（19/30），高于对照组的36.7%（11/30）（P＜0.05）；观察组中医证候总有效率为93.33%（28/30），高于对照组的60.0%（18/30）（P＜0.05）；观察组临床总有效率为83.3%（25/30），高于对照组的63.3%（19/30）（P＜0.05）。 结论王氏养卵汤联合来曲唑能够调节血瘀肾虚型PCOS伴不孕症患者体内性激素水平，改善患者慢性炎症及胰岛素抵抗状态，进一步提高排卵率，从而提高妊娠率，降低流产率。
Abstract:
ObjectiveTo observe clinical effects of Wang's egg-fostering decoction (Wangshi Yangluan Tang) and letrozole in the treatment of polycystic ovarian syndrome (PCOS) and infertility. MethodsSixty patients suffering PCOS and infertility were divided into the control group and the observation group using random number table method with 30 cases in each group. The control group was treated with letrozole, and the observation group took Wang's egg-fostering decoction on the foundation of Western medicine. To compare the levels of sex hormone such as LH, FSH, E2, PRL and T, serum FINS, the expressions of TNF-α, ovulation rate, pregnancy rate, clinical effects of TCM syndrome and clinical total effective rates between both groups. ResultsAfter the treatment, the expressions of LH, PRL and T were lower than these before the treatment in the two groups (P<0.05), the levels of FSH and E2 higher than these before the treatment (P<0.05), the levels of LH, PRL and T of the observation group were lower than these of the control group (P<0.05), the expressions of E2 were higher than these of the control group (P<0.05); the levels of FINS and TNF-α in the serum were lower than before the treatment in the two groups (P<0.05), the observation group was lower than the control group (P<0.05); the ovulation rate of the observation group was 83.3% (25/30), higher than 50.0% (15/30) of the control group (P<0.05); the pregnancy rate of the observation group was 63.3% (19/30), higher than 36.7% (11/30) of the control group (P<0.05); total effective rate of TCM syndrome of the observation group was 93.3% (28/30), higher than 60.00% (18/30) of the control group (P<0.05); clinical total effective rate of the observation group was 83.3% (25/30), higher than 63.3% (19/30) of the control group (P<0.05). ConclusionWang's egg-fostering decoction and letrozole could regulate the levels of sex hormone in the treatment of blood stasis and kidney deficiency type of PCOS and infertility, improve chronic inflammation and insulin resistance, further raise the ovulation rate, thus raising the pregnancy rate and reducing the abortion rate.

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备注/Memo

备注/Memo:
白煜君（1998—），女，硕士学位。研究方向：中医药治疗不孕不育的临床研究。国家中医药管理局科技司共建科技项目（GZY-KJS-SD-2023-009）；山东省中医药科技项目（2021M109）；淄博市医药卫生科技项目（20231504103）。
更新日期/Last Update: 2024-10-15