[1]赵进东,余婵娟,程若东,等.基于肠道菌群-胆汁酸路径探讨中药调节糖代谢的研究进展[J].西部中医药,2025,38(03):103-106.[doi:10.12174/j.issn.2096-9600.2025.03.19]
　ZHAO Jindong,YU Chanjuan,CHENG Ruodong,et al.Research Progress in the Regulation of Glucose Metabolism with Herbs Based on Gut Microbiota-Bile Acid Pathway[J].Western Journal of Traditional Chinese Medicine,2025,38(03):103-106.[doi:10.12174/j.issn.2096-9600.2025.03.19]
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基于肠道菌群-胆汁酸路径探讨中药调节糖代谢的研究进展()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年03期
页码:
103-106
栏目:
研究进展
出版日期:
2025-03-15

文章信息/Info

Title:
Research Progress in the Regulation of Glucose Metabolism with Herbs Based on Gut Microbiota-Bile Acid Pathway
作者:
赵进东1,2, 余婵娟1, 程若东1, 李金菊1, 方朝晖1,3
1.安徽中医药大学第一附属医院，安徽 合肥 230031
2.合肥综合性国家科学中心大健康研究院新安医学与中医药现代化研究所，安徽 合肥 230038
3.安徽省中医药科学院糖尿病研究所，安徽 合肥 230038
Author(s):
ZHAO Jindong1,2, YU Chanjuan1, CHENG Ruodong1, LI Jinju1, FANG Zhaohui1,3
1.The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China
2.Center for Xin’an Medicine and Modernization of Traditional Chinese Medicine of Institute of Health and Medicine, Hefei Comprehensive National Science Cent
关键词:
2型糖尿病; 中药; 肠道菌群; 胆汁酸; 胆汁酸法尼酯X受体; G蛋白偶联的胆汁酸受体1
Keywords:
type 2 diabetes mellitus; herbs; Gut Microbiota; bile acids; farnesyl X receptor; G protein-coupled bile acid receptor-1
分类号:
R255.4
DOI:
10.12174/j.issn.2096-9600.2025.03.19
文献标志码:
A
摘要:
对相关文献进行梳理，认为中药通过改善肠道菌群中的属、种等水平而调节血浆胆汁酸代谢，抑制肠与肝中的胆汁酸法尼酯X受体和G蛋白偶联的胆汁酸受体1，从而增加能量消耗，促进胰高血糖素样肽1分泌，抑制肝糖异生和促进肝糖原合成，发挥改善葡萄糖代谢作用。黄芩、黄连、栀子、附子以及黄连解毒汤、葛根芩连汤等调节糖代谢可能是基于影响肠道菌群-胆汁酸路径而实现的。
Abstract:
Through sorting out the relevant literature, herbs could adjust the metabolism of bile acid in the plasma through improving genera and species in the Gut Microbiota, and then inhibiting the expressions of farnesyl X receptor and G protein-coupled bile acid receptor-1 in the intestines and liver, thereby increasing energy consumption, promoting the secretion of glucagon-like peptide 1, inhibiting hepatic gluconeogenesis and promoting the synthesis of hepatic glycogen, improving the effects of glucose metabolism, for instance, the effects of the drugs, such as Huangqin (Scutellariae radix), Huanglian (Coptidis rhizoma), Zhizi (Gardeniae fructus), Fuzi (Aconiti lateralis radix praeparata), Huanglian Jiedu Tang, Gegen Qinlian Tang, may was realized by affecting Gut Microbiota-bile acid pathway.

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备注/Memo

备注/Memo:
赵进东（1985—），男，博士学位，副主任医师。研究方向：中医药防治内分泌代谢性疾病。国家自然科学基金（81603574，82174153）；安徽省卫生健康科研项目（AHWJ2023BAc10002）；糖脂代谢病教育部重点实验室开放基金项目（GYDKFXM01）；安徽省高校优秀拔尖人才培育项目（2022-371）；安徽省卫生健康骨干人才培养对象（2022-392）；2023年度新时代育人省级质量工程项目（研究生教育）建设项目（2023gjxslt014）；安徽省高等学校省级质量工程项目（2021jyxm0
更新日期/Last Update: 2025-03-15