[1]熊巍,王贵梅,谌婕.消增强骨丸对肝肾阴虚型骨质疏松症患者骨转换标志物的影响[J].西部中医药,2024,37(04):116-119.[doi:10.12174/j.issn.2096-9600.2024.04.23]
　XIONG Wei,WANG Guimei,CHEN Jie.Effect of Xiaozeng Qianggu Pill on Bone Turnover Markers in Patients with Osteoporosis of Liver and Kidney Yin Deficiency Pattern[J].Western Journal of Traditional Chinese Medicine,2024,37(04):116-119.[doi:10.12174/j.issn.2096-9600.2024.04.23]
点击复制

消增强骨丸对肝肾阴虚型骨质疏松症患者骨转换标志物的影响
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年04期
页码:
116-119
栏目:
临床研究
出版日期:
2024-04-15

文章信息/Info

Title:
Effect of Xiaozeng Qianggu Pill on Bone Turnover Markers in Patients with Osteoporosis of Liver and Kidney Yin Deficiency Pattern
作者:
熊巍1, 王贵梅1, 谌婕2
1.四川省骨科医院，四川 成都 610041
2.大邑志昌骨科医院，四川 大邑 611330
Author(s):
XIONG Wei1, WANG Guimei1, CHEN Jie2
1.Sichuan Province Orthopedic Hospital, Chengdu 610041, China
2.Dayi Zhichang Orthopedic Hospital, Dayi 611330, China
关键词:
骨质疏松症; 骨密度; 骨转换标志物; 肝肾阴虚
Keywords:
osteoporosis; bone mineral density; bone turnover markers; liver and kidney deficiency
分类号:
R681
DOI:
10.12174/j.issn.2096-9600.2024.04.23
文献标志码:
B
摘要:
目的探讨消增强骨丸对肝肾阴虚型骨质疏松症患者骨转换标志物的影响。 方法选取80例肝肾阴虚型骨质疏松症患者，随机分成观察组和对照组，每组40例。对照组予以碳酸钙D3片、骨化三醇软胶囊及阿仑膦酸钠片，观察组在对照组的基础上服用消增强骨丸，两组均治疗6个月。治疗后比较两组腰椎骨密度（bone mineral density，BMD）、髋部BMD、血清25-（OH）VitD、Ⅰ型胶原羧基端肽β特殊序列（β-C-terminal telopeptide of type I collagen，β-CTX）、Ⅰ型原胶原氨基端延长肽（propeptide of type 1 procollagen，PINP）、骨碱性磷酸酶（bone specific alkaline phosphatase，BALP）、骨钙素（bone gla protein，BGP）及腰部视觉模拟评分法（visual analogue scale，VAS）评分。 结果两组治疗前腰椎BMD、髋部BMD、25-（OH）VitD、β-CTX、PINP、BALP、BGP、腰部VAS评分之间比较，差异无统计学意义（P＞0.05）。治疗后观察组腰椎BMD、髋部BMD、25-（OH）VitD、PINP、BALP、BGP较对照组增高，观察组β-CTX、腰部VAS评分较对照组降低（P＜0.05）。 结论消增强骨丸治疗肝肾阴虚型骨质疏松症患者疗效可靠，可以影响骨转换标志物，提高骨密度，缓解患者腰部疼痛症状。
Abstract:
ObjectiveTo explore the effects of Xiaozeng Qianggu pills on bone turnover markers in patients with liver and kidney yin deficiency pattern osteoporosis. MethodsEighty patients with osteoporosis of liver and kidney yin deficiency pattern were selected and randomly divided into observation group and control group, with 40 cases in each group. The control group was given calcium carbonate D3 tablets, calcitriol soft capsules and alendronate sodium tablets, while the observation group was treated with Xiaozeng Qianggu pills, Both groups were treated for six months. After treatment, to compare BMD, sciatic BMD, 25-(OH)VitD, β-CTX, PINP, BALP, BGP and lumbar VAS scores between both groups. ResultsThe difference had no statistical meaning in the comparisons between lumbar BMD, sciatic BMD, 25-(OH)VitD, β-CTX, PINP, BALP, BGP and lumbar VAS scores between both groups before the treatment (P>0.05). After the treatment, lumbar BMD, sciatic BMD, 25-(OH)VitD, PINP, BALP and BGP of the observation group were increased than these of the control group, β-CTX and lumbar VAS scores of the observation group were lowered than these of the control group (P<0.05). ConclusionXiaozeng Qianggu pills could obtain reliable clinical effects in the treatment of liver and kidney yin deficiency pattern osteoporosis, It can affect bone turnover markers, increase BMD, and relieve patients' waist pain symptoms.

相似文献/References:

[1]张彩凤,程卫东△,王彩霞,等.玫参胶囊治疗围绝经期骨质疏松症60例[J].西部中医药,2012,25(05):16.
　ZHANG Cai-feng,CHENG Wei-dong,WANG Cai-xia,et al.MeiShen Capsule in Treating 60 Cases of Menopausal Osteoporosis[J].Western Journal of Traditional Chinese Medicine,2012,25(04):16.
[2]张德宏,李晶.老年骨质疏松症的病因病机及防治原则探析[J].西部中医药,2013,26(03):90.
　ZHANG Dehong,LI Jing.The Etiology, Pathogenesis and Prevention Principles of Senile Osteoporosis[J].Western Journal of Traditional Chinese Medicine,2013,26(04):90.
[3]李晶,宋敏△,罗晓,等.淫羊藿总黄酮对去势大鼠股骨骨组织形态学及生物力学的影响*[J].西部中医药,2014,27(07):13.
　LI Jing,SONG Min,LUO Xiao,et al.Effects of Total Flavonoids of Epimedium on Biodynamics and Bone Morphological Metrology of Ovariectomized Rats[J].Western Journal of Traditional Chinese Medicine,2014,27(04):13.
[4]李非,李红专,叶丙霖.原发性骨质疏松症的中医药研究现状[J].西部中医药,2016,29(03):136.
　LI Fei,LI Hongzhuan,YE Binlin.Research Status of Primary Osteoporosis[J].Western Journal of Traditional Chinese Medicine,2016,29(04):136.
[5]王继宏,杨鹏玲.柴芍抗松汤治疗老年原发性骨质疏松症伴抑郁39例[J].西部中医药,2018,31(10):74.
　WANG Jihong,YANG Pengling.ChaiShao KangSong Decoction in Treating 39 Senile Patients Suffering Primary Osteoporosis Accompanying Depression[J].Western Journal of Traditional Chinese Medicine,2018,31(04):74.
[6]张长彪,彭冉东,赵军,等.益肾地黄汤联合利塞膦酸钠治疗肾阳虚型绝经后骨质疏松症45例[J].西部中医药,2017,30(04):1.
　ZHANG Changbiao,PENG Randong,ZHAO Jun,et al.YiShen Dihuang Tang Combined with Risedronate Sodium in the Treatment for 45 Cases of Postmenopausal Osteoporosis of Kidney Yang Deficiency Type[J].Western Journal of Traditional Chinese Medicine,2017,30(04):1.
[7]董林,雷宁波,邢涛,等.损伤胶囊对绝经后骨质疏松症患者疼痛、骨密度及骨代谢生化指标的影响[J].西部中医药,2017,30(11):8.
　DONG Lin,LEI Ningbo,XING Tao,et al.The Effects of Damage Capsules on the Pain, Bone Mineral Density and Biochemical Markers of Bone Metabolism of Postmenopausal Osteoporosis Patients[J].Western Journal of Traditional Chinese Medicine,2017,30(04):8.
[8]马风英.仙灵骨葆胶囊联合甲氨蝶呤治疗类风湿性关节炎继发骨质疏松症37例[J].西部中医药,2018,31(02):98.
　MA Fengying.XianLing GuBao Capsules Combined with Methotrexate in Treating 37 Rheumatiod Arthritis Patients with Secondary Osteoporosis[J].Western Journal of Traditional Chinese Medicine,2018,31(04):98.
[9]叶丙霖,李盛华,王想福,等.补肾活血类中药治疗绝经期骨质疏松症的研究进展[J].西部中医药,2018,31(03):136.
　YE Binglin,LI Shenghua,WANG Xiangfu,et al.Study on Kidney-tonifying Blood-activating Herb in Treating Menopausal Osteoporosis[J].Western Journal of Traditional Chinese Medicine,2018,31(04):136.
[10]赵永杰,王翰宇,胡广兵,等.中药辅助治疗原发性骨质疏松症的用药规律[J].西部中医药,2018,31(06):65.
　ZHAO Yongjie,WANG Hanyu,HU Guangbing,et al.Research on the Administration Rules of TCM in Adjunctive Therapy for Primary Osteoporosis[J].Western Journal of Traditional Chinese Medicine,2018,31(04):65.
[11]谢栋,陈大军,马国亮,等.原发性骨质疏松症的骨密度与中医脏腑辨证的相关性研究*[J].西部中医药,2015,28(02):82.
[12]梁敏.绝经后骨质疏松症42例护理体会[J].西部中医药,2015,28(12):129.
[13]熊巍,王贵梅.抗骨质疏松胶囊对绝经后骨质疏松症患者骨密度及骨代谢生化指标的影响[J].西部中医药,2022,35(03):104.[doi:10.12174/j.issn.2096-9600.2022.03.23]
　XIONG Wei,WANG Guimei.Influence of Anti-osteoporosis Capsules on Bone Mineral Density and Bone Metabolism Biochemical Markers in Patients with Postmenopausal Osteoporosis[J].Western Journal of Traditional Chinese Medicine,2022,35(04):104.[doi:10.12174/j.issn.2096-9600.2022.03.23]
[14]张斌,秦永,范道波,等.基于PI3K/Akt信号通路探讨益气温阳活血方对老年肾虚血瘀型骨质疏松患者骨代谢的影响[J].西部中医药,2022,35(07):68.[doi:10.12174/j.issn.2096-9600.2022.07.18]
　ZHANG Bin,QIN Yong,FAN Daobo,et al.Effects of Benefiting-Qi Warming-Yang Activating-blood Prescription on Bone Metabolism in Senile Patients with Renal Deficiency and Blood Stasis Pattern Osteoporosis Based on P13K/Akt Signal Pathway[J].Western Journal of Traditional Chinese Medicine,2022,35(04):68.[doi:10.12174/j.issn.2096-9600.2022.07.18]

备注/Memo

备注/Memo:
熊巍（1980—），男，主治医师。研究方向：骨科疾病的中西医结合治疗。E-mail：459440204@qq.com。国家自然科学基金项目（81503444）；陕西省自然科学基础研究计划（2020JQ-966）；西安市科协青年人才托举计划（095920201330）。 中文作者简介:国家自然科学基金（2012BAK21B01）。
更新日期/Last Update: 2024-04-15