青蒿琥酯联合奎宁马斯治疗疟疾90例临床观察-《西部中医药》

文章信息/Info

Title:: Clinical Observation on Treating 90 Cases of Malaria with Artesunate and Quinimax Injection

Author(s):: FAN Chun-hui; Central Hospital of Bailongjiang Forstry Administration Office in Gansu Province, Longnan 746010, China

摘要:: 目的：观察青蒿琥酯联合奎宁马斯治疗疟疾的临床效果。方法：将180例疟疾患者根据入院顺序分为治疗组与对照组各90例，2组均给予奎宁马斯针剂静脉滴注治疗，治疗组同时给予青蒿琥酯针剂静脉滴注。结果：治疗组显效率显著高于对照组(P＜0.05)，2组总有效率差异无统计学意义(P＞O.05)。治疗组平均退热时间、平均原虫转阴时间均比对照组短(P＜0.05)，24小时平均原虫下降率高于对照组(P＜0.05)；不良反应明显少于对照组(P＜0.05)。结论：青蒿琥酯联合奎宁马斯治疗疟疾疗效显著，可改善临床症状，且安全性好。

Abstract:: Objective: To explore clinical effects of artesunate and quinimax in treating malaria. Method: All 180 patients were divided into treatment group and control group in the order of hospitalization. Both groups received intravenous quinimax injection. Threatment group were given with intravenous artesunate. Result: Effectual rate of treatment group was higher than that of control group(P＜0.05), comparison of both groups showed no statistical meaning in total effective rate(P＞0.05). Average time of defervescence and mean time of parasite clearance of treatment group were shorter than that of control group(P＜0.05), 24 h mean decline rate of parasite of treatment group was higher than that of control group(P＜0.05), Adverse reactions were remarkably less than that of control group (P＜0.05). Conclusion: Artesunate and quinimax injection are effective and safe in treating malaria and could improve clinical symptoms.