肝豆状核变性患者尿酶和尿微量蛋白的检测及分析-《西部中医药》

文章信息/Info

Title:: Detection and Analysis on Urease and Urinary Micro-albumin of Patients with Hepatolenticular Degeneration

作者:: 陈后勤1，胡纪源2△，吴君霞2，薛明月2，刘庆云2，马心锋2，张杰2; 1 安徽中医学院研究生部，安徽合肥 230038； 2 安徽中医学院神经病学研究所

Author(s):: CHEN Hou-qin1, HU Ji-yuan2△, WU Jun-xia2, XUE Ming-yue2, LIU Qing-yun2, MA Xin-feng2, ZHANG Jie2; 1 Graduate Department of Anhui University of Traditional Chinese Medicine, Hefei 230038, China； 2 Psychiatric Institute of Anhui University of Traditional Chinese Medicine

Keywords:: urinary micro-albumin; retinol binding protein(RBP); urinary N-acetyl β-d-glucosaminidase(NAG); hepatolenticular degeneration (HLD); renal injury in early times

摘要:: 目的：探讨尿微量白蛋白(mALB)、视黄醇结合蛋白(RBP)和尿N-乙酰-β-d-氨基葡萄糖苷酶(NAG)检测对肝豆状核变性(HLD)早期肾脏损伤的诊断价值及其在不同类型HLD中测定值是否存在差异。方法：采用免疫比浊法检测尿mALB和RBP水平，采用连续监测法检测尿NAG水平。结果：各中医证型及西医临床分型HLD组尿mALB、RBP和NAG测定值均较正常对照组显著增高(P＜0.01)；而各中医证型及西医临床分型组组间mALB、RBP及NAG测定值比较，差异无统计学意义(P＞0.05)。其在尿常规尿蛋白定性阴性HLD中阳性率分别为RBP94.74%、mALB78.07%和NAG35.09%。其中mALB与NAG呈正相关(r=0.26，P＜0.01)，mALB与RBP水平呈正相关(r=0.232，P＜0.01)，NAG与RBP水平呈正相关(r=0.180，P＜0.01)。结论：尿mALB、RBP和NAG检测对HLD早期肾损害具有诊断价值，其中RBP阳性率最高达94.74%。HLD各中医证型与西医临床分型间尿mALB、RBP和NAG水平无明显差异。

Abstract:: Objective: To survey diagnostic value of urinary micro-albumin(mALB), retinol binding protein (RBP), urinary N-acetyl β-d-glucosaminidase(NAG) detection on renal surgery in early times of hepatolenticular degeneration(HLD) and whether the difference existed in index of different HLD. Method: Levels of urinary mALB and RBP were detected with immunoturbidimetry and level of urinary NAG was tested with the continuous monitoring method. Result: Urinary mALB, RBP, NAG of TCM pattern and western medicine pattern groups were higher than normal control group (P＜0.01); comparison among groups had no statistical meaning in mALB, RBP and NAG (P＞0.05). Positive rates of HLD were respectively: RBP(94.74%), mALB (78.07%) and MAG(35.09%). mALB is positively associated to NAG (r=0.26, P＜0.01) and RBP (r=0.232,P＜0.01), NAG is positively related to RBP (r=0.180, P＜0.01). Conclusion: Urinary mALB, RBP and NAG show diagnostic value to renal injury in early time of HLD, among them, positive rate of RBP can reach to 94.74%. There is no significant difference among mALB, RBP and NAG in different patterns of HLD.