[1]王凤清,刘艳春.艾迪注射液联合CAG方案治疗老年急性髓细胞白血病40例疗效观察[J].西部中医药,2012,25(12):85-87.
　WANG Feng-qing,LIU Yan-chun.Observation on AiDi Injection and CAG Plan in Treating 40 Cases of Senile Acute Myelocytic Leukemia[J].Western Journal of Traditional Chinese Medicine,2012,25(12):85-87.
点击复制

艾迪注射液联合CAG方案治疗老年急性髓细胞白血病40例疗效观察
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
25
期数:
2012年12期
页码:
85-87
栏目:
出版日期:
2012-12-15

文章信息/Info

Title:
Observation on AiDi Injection and CAG Plan in Treating 40 Cases of Senile Acute Myelocytic Leukemia
文章编号:
1004-6852(2012)12-0085-03
作者:
王凤清1，刘艳春2
1 唐山市丰南区医院，河北 唐山 063300；2 唐山市工人医院
Author(s):
WANG Feng-qing1, LIU Yan-chun2
1 Tangshan Municipality Fengnan District Hospital, Tangshan 063300, China; 2 Tangshan Municipality Labor Hospital
关键词:
髓细胞白血病; 急性; 化疗; 老年人
Keywords:
myelocytic leukemia;  acute;  radiotherapy;  the elderly
分类号:
R733.71
文献标志码:
B
摘要:
目的：观察艾迪注射液联合CAG方案治疗老年急性髓细胞白血病的疗效及安全性。方法：将80例患者随机分为观察组和对照组各40例。2组均采用CAG方案：阿糖胞苷(Ara-c)10mg/m2，皮下注射q12h(第1-14天)；阿克拉霉素(Acla)10-14mg/(m2·d)，静脉注射(第1-4天)；粒系集落刺激因子(G-CSF)200μg/(m2·d)，皮下注射(第1-14天)。观察组同时加用艾迪注射液50mL/d，静脉滴注(第1-14天)。结果：完全缓解率观察组75.00%，对照组62.50%，2组差异显著(P＜0.05)；总有效率观察组85.00%，对照组75.00%，2组差异显著(P＜0.05)。1年生存率观察组为65.00%，对照组为45.00%，2组相比差异显著(P＜0.05)；3年生存率观察组为37.50%，对照组为25.00%，2组相比差异显著(P＜0.05)。身心健康、心理健康、社会关系、环境因素等指标治疗后观察组分别(25.7±6.2)(23.3±3.7)(23.7±6.4)(22.4±4.6)分，对照组分别为(15.7±6.2)(14.3±3.7)(14.7±6.4)(17.4±4.6)分，2组均明显好转(P＜0.05)，观察优于对照组(P＜0.05)。结论：艾迪注射液联合CAG方案治疗老年急性髓细胞白血病疗效确切，相对安全，耐受性好。
Abstract:
Objective: To observe clinical effects and safety of AiDi injection and CAG plan in treating senile acute myelocytic leukemia. Method: Eighty Patients were randomly divided into observation group and control group equally. Both groups received CAG plan: cytosine arabinoside (Ara-c) 10 mg/m2, subcutaneous injection q12h, from the first to 14th day; Aclacinomycin (Acla) 10 to 14 mg/(m2·d), intravenous dripping from the 1st to 4th day; granulocyte-colony stimulating factor (G-CSF), 200 μg/ (m2·d), subcutaneous injection, from the first to 14th day. Observation group were also given with intravenous dripping of AiDi injection from the 1st to 14th day,50mL/d. Result: Total remission rate of observation group was 75.00%, higher than 62.50% of control group with significant difference (P＜0.05); total effective rate of observation group was 85.00%, superior to 75.00% with significant difference (P＜0.05). One-year survival rate of observation group was 65.00%, higher than 45.00% of control group with significant difference (P＜0.05); three-year survival rate of observation group was 37.50%, higher than 25.00% of control group with significant difference (P＜0.05). Scales of observation group were (25.7±6.2),(23.3±3.7), (23.7±6.4) and (22.4依4.6) in physical and mental health, mental health, social relations, environmental factors and others indexes, superior to (15.7±6.2), (14.3±3.7), (14.7±6.4) and (17.4±4.6) of control group (P＜0.05),both groups improved remarkably (P＜0.05). Conclusion:AiDi injection and CAG plan are effective and safe in treating senile acute myelocytic leukemia with high tolerance.

参考文献/References:

［1］ Godwin J.Design and conduct of a double-blind，placebo-controlled trial of daunorubicin and cytarabine with or without granulocyte colong-stimulating factor in elderly patients with acute myeloid leukemia：a southwest oncology group study［J］.J Natl Cancer Inst Monogy，1995(19)：31-35. ［2］ 张之南.血液病诊断及疗效标准［M］.北京：科学出版社，1998：214. ［3］ 上海市白血病协作组.上海地区老年急性白血病 417 例回顾性研究［J］.中华血液学杂志，1998，19(1)：3. ［4］ Copplestone JA，Smith AG.Acute myeloid leukemia：in the elderly［J］.Leuk Res，1988，12：617-625. ［5］ 王志慧.化疗联合抗白恒生汤治疗急性淋巴细胞白血病 21例［J］.甘肃中医，2010，23（11）：44-45. ［6］ 王永胜，侯伟，李欲来.川芎嗪注射液治疗高白细胞急性白血病疗效观察［J］.河北中医，2011，33（4）：586-587. ［7］ 苏云明，王欣，孟繁兴，等.灵芪胶囊含药血清对人红白血病K562 细胞增殖抑制作用的影响［J］.中医药信息，2009，26（1）：83-86. ［8］ Stone RM.The difficult problem of acute myeloid leukemia in the older adult［J］.CA Cancer J Clin，2002，52(6)：363-371. ［9］ Yamada K，Furusawa S，Saito K，et al.Concurrent use of granulocyte colony-stimulating factor with low-dose cytosine arabinoside and aclarubicin for previously treated acute myelogenous leukemia：a pilot study［J］.Leukamia，1995，9(1)：10-14. ［10］Saito K，Nakamura Y，Aoyagi M，et al.Low-dose cytarabine and aclarubicin in combination with granulocyte colonystimulating factor(CAG regimen)for previously treated patients with relapsed or primary resistant acute myelogenous leukemia(AML)and previously untreated elderly patients with AML secondary AML.and refractory anemia with excese blasts in transformation［J］.Int J Hematol，2000，71(3)：238-244. ［11］ Bai A，Kojima H，Hori M，et al.Priming with G-CSF effectively enhances low-dose Arac-cinduced in vivo apotosis in myeloid leukemia cells［J］.Exp Hematol，1999，27(2)：259-265. ［12］陈丽梅，李超民，关健虹，等.艾迪注射液与化疗联合应用治疗血液系统恶性肿瘤的临床疗效观察［J］.肿瘤防治杂志，2004，11(2)：175，183.

相似文献/References:

[1]张永全,张惠玉,仝树坡,等.急性脑梗死肝阳暴亢证患者血脂及经颅多普勒检查结果的相关性研究[J].西部中医药,2011,24(11):38.
[2]李雅娟.急性重症胰腺炎62例临床护理干预观察[J].西部中医药,2013,26(03):115.
　LI Yajuan.Observation on Nursing Intervention for 62 Patients with Acute Severe Pancreatitis[J].Western Journal of Traditional Chinese Medicine,2013,26(12):115.
[3]张世祥,贾兴梅,高鹏,等.中西医结合治疗急性重症胰腺炎18例临床研究[J].西部中医药,2013,26(05):102.
　ZHANG Shixiang,JIA Xingmei,GAO Peng,et al.Clinical Study on Integrative Medicine in Treating 18 Cases of Severe Acute Pancreatitis[J].Western Journal of Traditional Chinese Medicine,2013,26(12):102.
[4]胡兰文,徐盛开,范玲莉.老年人急性心肌梗死的临床特征及中医证型分析[J].西部中医药,2013,26(06):44.
　HU Lanwen,XU Shengkai,FAN Lingli.Clinical Characteristics and Patterns Analysis of Acute Myocardial Infarction in the Elderly[J].Western Journal of Traditional Chinese Medicine,2013,26(12):44.
[5]孙志江,王映珍,徐庆杰.大黄内服配合芒硝外敷治疗重症急性胰腺炎患者43例[J].西部中医药,2012,25(08):70.
　SUN Zhi-jiang,WANG Ying-zhen,XU Qing-jie.DaHuang for Oral Administration Combined with MangXiao for External Use in Treating 43 Patients with Severe Acute Pancreatitis[J].Western Journal of Traditional Chinese Medicine,2012,25(12):70.
[6]刘康乐.中西药物联用治疗小儿急性支气管炎86例[J].西部中医药,2013,26(08):90.
　LIU Kangle.Clinical Observation on Treating 86 Cases of Children Suffering from Acute Bronchitis with Integrative Medicine[J].Western Journal of Traditional Chinese Medicine,2013,26(12):90.
[7]董莉莉,王军燕,刘安国,等.针灸治疗急性胃炎的临床选穴规律研究*[J].西部中医药,2013,26(11):129.
　DONG Lili,WANG Junyan,LIU Anguo,et al.Study on Acupoint Selection for Treating Acute Gastritis with Acupuncture[J].Western Journal of Traditional Chinese Medicine,2013,26(12):129.
[8]陈少兰,徐胜珍△.中西医结合护理对急性心肌梗死患者康复效果的影响[J].西部中医药,2014,27(04):129.
　CHEN Shaolan,XU Shengzhen.Influence of Nursing on the Patients with Acute Myocardial Infarction at Recovery Stage by Integrative Medicine[J].Western Journal of Traditional Chinese Medicine,2014,27(12):129.
[9]张兆耘.丹红注射液治疗脑梗塞急性期52例[J].西部中医药,2014,27(06):76.
　ZHANG Zhaoyun.DanHong Injection in Treating 52 Cases of Acute Cerebral Infarction[J].Western Journal of Traditional Chinese Medicine,2014,27(12):76.
[10]魏丹,王安萍△.丙氨酰谷氨酰胺联合血必净注射液治疗重症急性胰腺炎38例[J].西部中医药,2014,27(06):106.
　WEI Dan,WANG Anping.Alanyl-glutamine and XueBiJing Injection in Treating 38 Cases of Severe Acute Pancreatitis[J].Western Journal of Traditional Chinese Medicine,2014,27(12):106.

备注/Memo

备注/Memo:
收稿日期：2012-09-27 作者简介：王凤清(1972—)，男，主治医师。研究方向：血液疾病的诊治。
更新日期/Last Update: 1900-01-01