[1]严亚锋,白海侠.消栓通络胶囊对急性脑缺血再灌注大鼠脑组织TNF-α和IL-1β水平的影响[J].西部中医药,2013,26(09):23-25.
　YAN Yafeng,BAI Haixia.Effects of XiaoShuangTongLuo Capsule on TNF-α and IL-1β in Cerebral Tissue of Rats with Acute Cerebral Ischemia-reperfusion Injury[J].Western Journal of Traditional Chinese Medicine,2013,26(09):23-25.
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消栓通络胶囊对急性脑缺血再灌注大鼠脑组织TNF-α和IL-1β水平的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年09期
页码:
23-25
栏目:
出版日期:
2013-09-15

文章信息/Info

Title:
Effects of XiaoShuangTongLuo Capsule on TNF-α and IL-1β in Cerebral Tissue of Rats with Acute Cerebral Ischemia-reperfusion Injury
文章编号:
1004-6852(2013)09-0023-03
作者:
严亚锋，白海侠
陕西中医学院，陕西 咸阳 712046
Author(s):
YAN Yafeng, BAI Haixia
Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China
关键词:
消栓通络胶囊; 脑缺血再灌注; TNF-α; IL-1β; 实验研究
Keywords:
XiaoShuang TongLuo capsule;  cerebral ischemia-reperfusion;  TNF-α;  IL-1β;  experimental study
分类号:
R285.5
文献标志码:
A
摘要:
目的：观察消栓通络胶囊对急性缺血性中风模型大鼠脑组织肿瘤坏死因子-α(TNF-α)和白介素-1β(IL-1β)水平的影响，以探讨其治疗缺血性中风的作用机制。方法：采用线栓法制备大鼠大脑中动脉缺血再灌注(MCAO)模型，测定大鼠脑组织中TNF-α和IL-1β的水平。结果：与模型组比较，消栓通络胶囊大、中(1.68、0.84 g/kg)剂量组可明显降低MCAO大鼠神经行为学评分(P＜0.01)，可明显降低MCAO大鼠患侧脑匀浆中TNF-α和IL-1β的水平(P＜0.01)。结论：消栓通络胶囊可提高急性脑缺血再灌注大鼠的神经功能活动能力，其治疗缺血性中风的作用机制可能与TNF-α和IL-1β的表达有关。
Abstract:
Objective: To discuss the mechanism of XiaoShuang TongLuo capsule in treating ischemic stroke through observing the effects of the drugs on TNF-α and IL-1β of cerebral tissue of rats with acute ischemic stroke. Method: Rat models with middle cerebral artery occlusion (MCAO) were established, the levels of TNF-α and IL-1β in cerebral tissue were detected. Result: Compared with the model group, high and middle dosage group of XiaoShuang TongLuo capsule (1.68 and 0.84g/kg) could obviously decrease the scales of neurological behavior of MACO rats remarkably (P＜0.01), and lower the levels of TNF-α and IL-1β in cerebral homogenate of the affected side in MACO rat (P＜0.01). Conclusion: XiaoShuang TongLuo capsule could improve the performance and neurological function of the rats with acute cerebral ischemia-reperfusion injury, its mechanism might be related to the expressions of TNF-α and IL-1β.

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备注/Memo

备注/Memo:
收稿日期：2013-02-20 作者简介：严亚锋(1976—)，男，硕士研究生，工程师，讲师，执业药师。研究方向：中药的药理学研究。
更新日期/Last Update: 2013-09-15