[1]吕立勋,李唐棣,赵琳琳,等.自制三清降糖缓释片对糖尿病兔血糖、血脂及氧化应激的影响*[J].西部中医药,2014,27(09):13-15.
点击复制

自制三清降糖缓释片对糖尿病兔血糖、血脂及氧化应激的影响*
分享到:

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
27
期数:
2014年09期
页码:
13-15
栏目:
出版日期:
2014-09-15

文章信息/Info

作者:
吕立勋1李唐棣1赵琳琳1赵利刚1吴范武2
1 河北联合大学药学院,河北 唐山 063000; 2 河北联合大学中医学院
关键词:
糖尿病血脂氧化应激三清降糖方缓释片
分类号:
R587.1
摘要:
目的:探讨自制三清降糖缓释片对糖尿病兔血糖、血脂及体内氧化应激水平的影响。方法:采用高脂高糖饮食喂养健康雄性家兔4周后,静脉注射链脲佐菌素制备糖尿病模型。将造模成功的家兔随机分为正常组、模型组、格列美脲组、三清降糖方汤剂、三清降糖缓释片组5组,灌胃给药4周后,生化法测血脂、血糖浓度;放免法测血清胰岛素,并计算胰岛素抵抗指数;双抗体夹心-ELISA法测肿瘤坏死因子-α(TNF-α);WST法测超氧化物歧化酶;比色法测丙二醛和谷胱甘肽。结果:糖尿病兔各给药组与用药前比较血糖、血脂及SOD值、血清胰岛素及其抵抗指数均有所下降(P<0.05),谷胱甘肽水平无变化(P>0.05);而MDA、TNF-α水平升高,各给药组比较无统计学差异(P>0.05)。结论:三清降糖缓释片对糖尿病兔具有降血糖、降脂作用,同时能减轻氧化应激改变。

相似文献/References:

[1]朱晓娜,李天浩.调脂柔脉颗粒治疗动脉粥样硬化性脑梗死的疗效评价[J].西部中医药,2012,25(10):77.
 ZHU Xiao-na,LI Tian-hao.Evaluation on Clinical Efficacy of TiaoZhi RouMai Granules in Treating Atherosclerotic Cerebral Infarction[J].Western Journal of Traditional Chinese Medicine,2012,25(09):77.
[2]段尚勤.糖脂消合罗格列酮治疗2型糖尿病合并非酒精性脂肪肝疗效观察[J].西部中医药,2013,26(02):88.
 DUAN Shangqin.Clinical Observation on TangZhiXiao and Rosiglitazone Maleate in Treating Type 2 Diabetes Mellitus Complicated with Non Alcoholic Fatty Liver Disease[J].Western Journal of Traditional Chinese Medicine,2013,26(09):88.
[3]张国民.消渴清颗粒治疗糖尿病周围神经病变疗效分析[J].西部中医药,2012,25(08):66.
 ZHANG Guo-min.XiaoKeQing Granules in Treating Diabetic Peripheral Neuropathy[J].Western Journal of Traditional Chinese Medicine,2012,25(09):66.
[4]张艳玲,高文菊.系统性干预对糖尿病并发症发生发展的影响[J].西部中医药,2013,26(12):81.
 ZHANG Yanling,GAO Wenju.Effects of Systematic Intervention on the Onset and Progression of Diabetic Complications[J].Western Journal of Traditional Chinese Medicine,2013,26(09):81.
[5]刘希宏.中西药物联用对老年高血压合并2型糖尿病患者肾功能的保护作用[J].西部中医药,2012,25(07):9.
 LIU Xi-hong.Protection of Integrated Traditional Chinese and Western Medicine on Renal Function of Patients with Senile Hypertension and Type 2 Diabetes Mellitus[J].Western Journal of Traditional Chinese Medicine,2012,25(09):9.
[6]王学琦,李丰华,张荣华,等.温肾汤治疗早期糖尿病肾病80例[J].西部中医药,2013,26(09):62.
 WANG Xueqi,LI Fenghua,ZHANG Ronghua,et al.WenShenTang for 80 Cases of Early Diabetic Nephropathy[J].Western Journal of Traditional Chinese Medicine,2013,26(09):62.
[7]呼宝娟.护理干预对肺结核合并糖尿病患者生活质量的影响[J].西部中医药,2013,26(09):125.
 HU Baojuan.Effects of Nursing Intervention on Life Quality of Diabetic Patients Complicated with Pulmonary Tuberculosis[J].Western Journal of Traditional Chinese Medicine,2013,26(09):125.
[8]王瑞福.调脂汤对冠心病PCI术后血液流变学及血脂的影响[J].西部中医药,2013,26(12):71.
 WANG Ruifu.Effects of TiaoZhi Tang on Blood Lipid and Rheology of the Patients with Coronary Heart Disease After PCI[J].Western Journal of Traditional Chinese Medicine,2013,26(09):71.
[9]梁伟.护理干预在2型糖尿病患者护理中的应用[J].西部中医药,2013,26(12):128.
 LIANG Wei.Application of Nursing Intervention to the Patients with Diabetes Mellitus Type 2[J].Western Journal of Traditional Chinese Medicine,2013,26(09):128.
[10]童玲利.外伤性跟骨骨折合并糖尿病患者围手术期护理体会[J].西部中医药,2014,27(02):131.
 TONG Lingli.Perioperative Care for the Patients with Diabetes Mellitus and Traumatic Calcaneal Fracture[J].Western Journal of Traditional Chinese Medicine,2014,27(09):131.
[11]龚云,王超,亢建国.运动结合灵芝多糖干预对糖尿病大鼠血脂的影响[J].西部中医药,2013,26(08):8.
 GONG Yun,WANG Chao,KANG Jianguo.Effects of Exercise and Ganoderan Intervention on Blood Fat of Rats with Diabetes Mellitus[J].Western Journal of Traditional Chinese Medicine,2013,26(09):8.
[12]张智明,陈孝民△.芪蛭消渴方联合西药基础治疗对 2 型糖尿病症状及血脂的影响*[J].西部中医药,2014,27(08):79.
[13]孟祥云,张之弘,汪永锋,等.当归多糖对糖尿病大鼠脂代谢及脂肪因子的影响?[J].西部中医药,2021,34(11):33.[doi:10.12174/j.issn.2096-9600.2021.11.07]
 MENG Xiangyun,ZHANG Zhihong,WANG Yongfeng,et al.Influence of Angelica Polysaccharide on Lipid Metabolism and Adipokine in Diabetic Rats[J].Western Journal of Traditional Chinese Medicine,2021,34(09):33.[doi:10.12174/j.issn.2096-9600.2021.11.07]
[14]侯杰军,吕予,路亚娥,等.益气养阴活血汤对2型糖尿病患者胰岛β细胞功能、血脂和血液流变学的影响[J].西部中医药,2021,34(02):85.[doi:10.12174/j.issn.2096-9600.2021.02.23]
 HOU Jiejun,LYU Yu,LU Yae,et al.Effects of Qi-invigorating Yin-nourishing Blood-activating Decoction on Hemorheology, Blood Lipids and Islet β Cell Function in Type Two Diabetes Mellitus Patients[J].Western Journal of Traditional Chinese Medicine,2021,34(09):85.[doi:10.12174/j.issn.2096-9600.2021.02.23]

备注/Memo

备注/Memo:
*基金项目:2011年唐山市科技支撑项目(编号1113020112a)作者简介:吕立勋(1972—),女,硕士学位,副教授。研究方向:中药药效物质基础及其制剂。
更新日期/Last Update: 2014-09-15