[1]孙丽英,秦鹏飞,张亮,等.增液汤对干燥综合征模型鼠血清肿瘤坏死因子-α和白介素-1β的影响*[J].西部中医药,2015,28(02):13-15.
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增液汤对干燥综合征模型鼠血清肿瘤坏死因子-α和白介素-1β的影响*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
28
期数:
2015年02期
页码:
13-15
栏目:
出版日期:
2015-02-15

文章信息/Info

文章编号:
1004-6852(2015)02-0013-03
作者:
孙丽英秦鹏飞张亮孙红丽
黑龙江中医药大学,黑龙江 哈尔滨 150040
关键词:
增液汤干燥综合征肿瘤坏死因子-α白细胞介素-1β
分类号:
R285.5
摘要:
目的:观察增液汤对干燥综合征模型鼠血清中肿瘤坏因子-α(TNF-α)和白细胞介素1β(IL-1β)的影响。方法:将54只ICR小鼠随机分为6组:空白组,模型组,来氟米特组和增液汤高、中、低剂量组。采用弗氏完全佐剂及ICR小鼠颌下腺蛋白抗原联合诱导干燥综合征(SS)动物模型,60天后眼球取血,采用ELISA法测定各组小鼠血清中TNF-α和IL-1β的含量。结果:模型组小鼠血清中TNF-α和IL-1β的含量均高于空白组,差异有统计学意义(P<0.05);来氟米特组和增液汤高、中、低剂量组小鼠血清中TNF-α和IL-1β的含量均低于模型组(P<0.05),增液汤高剂量组小鼠血清中TNF-α和IL-1β的含量明显低于来氟米特组(P<0.05),中剂量组小鼠血清中TNF-α和IL-1β的含量明显介于高、低剂量组之间。结论:增液汤治疗SS模型小鼠的机制之一可能是降低了血清中TNF-α和IL-1β的表达水平,而且增液汤剂量越大效果越明显。

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备注/Memo

备注/Memo:
*基金项目:黑龙江省教育厅科学技术研究项目计划(编号12511529)。作者简介:孙丽英(1966—),女,硕士研究生导师,博士学位,教授。研究方向:方剂的配伍规律及疗效客观化。
更新日期/Last Update: 2015-02-15