[1]吉利,张艳.益气通脉饮对慢性心力衰竭大鼠心功能及血清TNF-α、IL-6、TGF-β1水平的影响[J].西部中医药,2015,28(05):25-27.
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益气通脉饮对慢性心力衰竭大鼠心功能及血清TNF-α、IL-6、TGF-β1水平的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
28
期数:
2015年05期
页码:
25-27
栏目:
出版日期:
2015-05-15

文章信息/Info

文章编号:
1004-6852(2015)05-0025-03
作者:
吉利，张艳
辽宁中医药大学附属医院心内一科，辽宁 沈阳 110032
关键词:
心力衰竭; 心功能; TNF-α; IL-6; TGF-β1; 益气通脉饮
分类号:
R285.5
文献标志码:
A
摘要:
目的：探讨益气通脉饮不同剂量给药对慢性心力衰竭(CHF)大鼠心功能以及血清TNF-α、IL-6、TGF-β1水平的影响。方法：将40只大鼠随机分为模型对照组、中药等效剂量组、中药大剂量组、西药对照组、正常对照组，每组8只。采用结扎大鼠左冠状动脉主干的方法复制急性心梗后心衰大鼠模型，造模成功后，中药等效剂量组与大剂量组分别按照5.4 g/kg（体质量）、16.2 g/kg（体质量）予益气通脉饮煎取液灌胃；西药对照组予科素亚混悬液，按4.5 mg/kg（体质量）灌胃，模型对照组与正常对照组以同体积生理盐水灌胃。1次/d，共8周。采用多普勒超声心动图机测定CHF大鼠的心功能，用放射免疫法检测大鼠血清中TNF-α、IL-6、TGF-β1的含量。结果：模型对照组ESV、LVEF、EDV、SV与正常对照组比较差异有统计学意义(P＜0.05)；与模型对照组比较，中药等效剂量组、西药对照组ESV、LVEF、EDV、SV有统计学差异(P＜0.05)；而中药大剂量组和西药对照组比较各项指标无明显差异(P＞0.05)，与正常对照组相比，模型对照组大鼠血清TNF-α、IL-6、TGF-β1水平显著增高(P＜0.01)；中药大剂量组、等效剂量组和西药对照组血清TNF-α、IL-6、TGF-β1水平均较模型对照组降低(P＜0.05)。而中药大剂量组、等效剂量组和西药对照组之间血清TNF-α、IL-6、TGF-β1水平比较差异无统计学意义(P＞0.05)。结论：益气通脉饮可改善CHF大鼠的心衰症状，降低血清中TNF-α、IL-6、TGF-β1水平，从而延缓慢性心力衰竭的发生和发展。

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备注/Memo

备注/Memo:
作者简介：吉利(1973—)，女，博士学位，副教授。研究方向：心血管内科疾病的临床教学与科研。
更新日期/Last Update: 2015-05-15