[1]王佳,王钢,王丽琴,等.秦艽醇提物治疗类风湿关节炎的实验研究[J].西部中医药,2015,28(07):11-14.
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秦艽醇提物治疗类风湿关节炎的实验研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
28
期数:
2015年07期
页码:
11-14
栏目:
出版日期:
2015-07-15

文章信息/Info

文章编号:
1004-6852(2015)07-0011-04
作者:
王佳，王钢，王丽琴，王涛，田杰祥
甘肃中医药大学附属医院，甘肃 兰州 730000
关键词:
类风湿关节炎; 胶原诱导性关节炎; 秦艽醇提物
分类号:
R285.5
文献标志码:
A
摘要:
目的：观察大叶秦艽醇提取物对胶原诱导性关节炎大鼠的防治作用，并探讨其作用机制。方法：将SPF级SD大鼠80只随机分为正常组、模型组、白芍组及秦艽组，每组20只。除正常组外，其余各组用胶原乳液多点皮内注射建立关节炎模型；秦艽组以秦艽乙醇提物1.8 mL（kg/d）灌胃；白芍组以白芍总苷胶囊内容物混悬液2 mL（kg/d）灌胃；正常组和模型组予等量蒸馏水灌胃。实验第24天、31天观察各组大鼠一般情况及关节X线片变化情况。结果：模型组大鼠踝关节及足趾关节明显肿胀、变形，秦艽组及白芍组与模型组比较关节肿胀程度明显减轻，其差异有统计学意义（P＜0.05）。结论：秦艽提取物能在早期改善胶原诱导性关节炎大鼠的一般情况，减轻关节肿胀程度，改善滑膜炎症状，保护关节，体现治疗早期RA的优势。

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备注/Memo

备注/Memo:
*基金项目：甘肃省中医药科学技术研究课题（编号 GZK-2010-3）。作者简介：王佳（1981—），男，硕士学位，主治医师。研究方向：骨病的中西医结合治疗。
更新日期/Last Update: 2015-07-15