[1]李晶,谢兴文,宋敏.淫羊藿总黄酮对去势大鼠腰椎椎体生物力学的影响[J].西部中医药,2016,29(01):15-16.
　LI Jing,XIE Xingwen,SONG Min.Influence of Total Flavonoids from YinYangHuo on Lumbar Vertebral Body Biomechanics of Castrated Rats[J].Western Journal of Traditional Chinese Medicine,2016,29(01):15-16.
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淫羊藿总黄酮对去势大鼠腰椎椎体生物力学的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
29
期数:
2016年01期
页码:
15-16
栏目:
出版日期:
2016-01-15

文章信息/Info

Title:
Influence of Total Flavonoids from YinYangHuo on Lumbar Vertebral Body Biomechanics of Castrated Rats
文章编号:
1004-6852(2016)01-0015-02
作者:
李晶1，谢兴文1，宋敏2
1 甘肃省中医药研究院，甘肃 兰州 730050； 2 甘肃中医药大学
Author(s):
LI Jing1, XIE Xingwen1, SONG Min2
1 Gansu Provincial Academy of Chinese Medicine, Lanzhou 730050, China;2 Gansu University of Traditional Chinese Medicine
关键词:
淫羊藿总黄酮; 生物力学; 去势大鼠
Keywords:
total flavonoids from YinYangHuo;  the biomechanics;  castrated rats
分类号:
R318
文献标志码:
A
摘要:
目的：探讨淫羊藿总黄酮对去势大鼠腰椎椎体生物力学的影响。方法：将10月龄SPF级雌性SD大鼠60只随机分为6组，每组10只，除正常对照组外，均行双侧卵巢切除术，术后1周给予淫羊藿总黄酮高、中、低剂量和β-雌二醇进行干预，采用万能材料试验机进行三点弯曲试验，检测腰椎椎体生物力学指标的变化情况。结果：模型对照组较其余各组生物力学指标显著下降(P＜0.01)。结论：大鼠去势后腰椎椎体的脆性增加，淫羊藿总黄酮可增强去势大鼠椎体的弹性，降低其脆性。
Abstract:
Objective: To explore the influence of total flavonoids from YinYangHuo(Epimedium brevicornu Maxim.) on lumbar vertebral body biomechanics of castrated rats. Methods: Sixty rats were randomly divided into six groups, ten rats each group. Except normal control group, the rats were performed oophorectomy bilaterally, and they were intervened by high, moderate and low doses of total flavonoids from YinYangHuo and β-estrogen in one week after the operation, three point bending test was performed by adopting universal testing machine to detect biomechanical indexes of lumbar vertebral body. Results: Biomechanical indexes of model control group decreased compared with other groups significantly (P＜0.01). Conclusion: Castration could cause the fragility of lumbar vertebral body of the rat increase, while total flavonoids from YinYangHuo could increase the elasticity of vertebral body of the rats and decrease its fragility.

相似文献/References:

[1]张 伟,李 晶△,宋 敏,等.淫羊藿总黄酮对去势大鼠钙、磷代谢的影响[J].西部中医药,2012,25(08):30.
　ZHANG Wei,LI Jing,SONG Min,et al.Influence of Total Flavonoids from YinYangHuo on Calcium and Phosphorus Metabolism of Emasculate Rat[J].Western Journal of Traditional Chinese Medicine,2012,25(01):30.
[2]张德宏,王兴盛,毕华焱,等.从生物力学角度探究腰椎管狭窄症术后残留下腰痛的可能机制及中医药研究进展[J].西部中医药,2019,32(03):140.
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[3]李晶,宋敏△,罗晓,等.淫羊藿总黄酮对去势大鼠股骨骨组织形态学及生物力学的影响*[J].西部中医药,2014,27(07):13.
　LI Jing,SONG Min,LUO Xiao,et al.Effects of Total Flavonoids of Epimedium on Biodynamics and Bone Morphological Metrology of Ovariectomized Rats[J].Western Journal of Traditional Chinese Medicine,2014,27(01):13.

备注/Memo

备注/Memo:
*基金项目：甘肃省自然科学基金计划项目(编号3ZS061-A25-109)。作者简介：李晶(1983—)，男，硕士学位，主治医师。研究方向：骨关节疾病的中医药防治。
更新日期/Last Update: 2016-01-15