[1]张邦能,舒畅,杜玫,等.昆仑雪菊水提物对2型糖尿病小鼠血糖及胰岛素水平的影响[J].西部中医药,2016,29(01):26-29.
　ZHANG Bangneng,SHU Chang,DU Mei,et al.Impact of Aqueous Extract from KunLun Snow Chrysanthemum on the Levels of Blood Glucose and Insulin of the Mice with Type Two Diabetes Mellitus[J].Western Journal of Traditional Chinese Medicine,2016,29(01):26-29.
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昆仑雪菊水提物对2型糖尿病小鼠血糖及胰岛素水平的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
29
期数:
2016年01期
页码:
26-29
栏目:
出版日期:
2016-01-15

文章信息/Info

Title:
Impact of Aqueous Extract from KunLun Snow Chrysanthemum on the Levels of Blood Glucose and Insulin of the Mice with Type Two Diabetes Mellitus
文章编号:
1004-6852(2016)01-0026-04
作者:
张邦能1，舒畅2，杜玫3，刘晓富4，杨丽霞1，李雪英2
1 甘肃省中医院，甘肃 兰州 730050； 2 甘肃中医药大学； 3 甘肃省建筑职工医院； 4 酒泉市中医院
Author(s):
ZHANG Bangneng1, SHU Chang2, DU Mei3, LIU Xiaofu4, YANG Lixia1, LI Xueying2
1 Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China;2 Gansu University of Traditional Chinese Medicine; 3 Gansu Provincial Construction Worker's Hospital;4 Jiuquan Municipality TCM Hospital
关键词:
2型糖尿病; 血糖; 昆仑雪菊; 小鼠
Keywords:
type two diabetes mellitus;  blood glucose;  Kunlun snow chrysanthemum;  the mice
分类号:
R587
文献标志码:
A
摘要:
目的：探讨昆仑雪菊水提物对2型糖尿病小鼠的降糖作用。方法：将2型糖尿病小鼠50只，按随机数字表法分为吡格列酮组、阳性对照组，昆仑雪菊高、中、低剂量组，每组10只，另设正常对照组10只。正常对照组和阳性对照组每日以0.001 mL/kg灌服0.9%氯化钠溶液；昆仑雪菊高、中、低剂量组每日分别以0.4、0.2、0.1 g/kg浓度按0.01 mL/g体质量灌服昆仑雪菊水溶液；吡格列酮组按每日0.01 g/kg灌服吡格列酮水溶液，1次/d，连续35天。观察小鼠一般情况及餐前、餐后2小时血糖，血清胰岛素及胰岛素敏感指数。结果：昆仑雪菊可显著降低病鼠体质量及空腹血糖值，效果优于吡格列酮；而在降低2小时血糖和提高胰岛素敏感性方面与吡格列酮药效相当。结论：昆仑雪菊具有降低2型糖尿病小鼠血糖、胰岛素水平及改善小鼠胰岛素抵抗的作用。
Abstract:
Objective: To explore the effects of Kunlun snow chrysanthemum on decreasing blood glucose of type two diabetes mellitus (T2DM) mice. Methods: Fifty T2DM mice were divided into pioglitazone group, positive control group, high, moderate and low doses groups of Kunlun snow chrysanthemum according to random number table, ten mice each group, ten mice in the normal control group were established. Normal control group and positive control group accepted intragastric administration of 0.9% sodium chloride solution by standard of 0.001 mL/kg each day; high, moderate and low doses groups of Kunlun snow chrysanthemum lavaged aqueous solution of Kunlun snow chrysanthemum in the concentrations of 0.4, 0.2 and 0.1 g/kg by standard of 0.01 mL/g; pioglitazone group aqueous solution of pioglitazone by standard of 0.01g/kg, once per day, for 35 consecutive days. General condition, preprandial blood glucose, 2hours postprandial blood glucose, serum insulin and insulin sensitivity index(ISI) were observed. Results: Kunlun snow chrysanthemum could significantly decrease body weight and fasting blood glucose of the mice, and its effects were superior to these of pioglitazone; while equivalent to pioglitazone in decreasing 2hours postprandial blood glucose and improving ISI. Conclusion: Kunlun snow chrysanthemum could decrease blood glucose and the levels of insulin of T2DM mice, and improve insulin resistance of the mice.

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备注/Memo

备注/Memo:
*基金项目：2013年甘肃省自然科学基金项目(编号1308RJZA106)。作者简介：张邦能(1970—)，男，副主任检验师。研究方向：糖尿病分子机制研究。
更新日期/Last Update: 2016-01-15