[1]谭超,安文蓉,刘娟,等.大柴胡汤中柴胡、大黄不同配比对抗炎镇痛作用的影响[J].西部中医药,2016,29(03):8-10.
　TAN Chao,AN Wenrong,LIU Juan,et al.HuangQin; body temperature; IL-1β; PGE2; genuine herbs[J].Western Journal of Traditional Chinese Medicine,2016,29(03):8-10.
点击复制

大柴胡汤中柴胡、大黄不同配比对抗炎镇痛作用的影响()
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
29
期数:
2016年03期
页码:
8-10
栏目:
出版日期:
2016-03-15

文章信息/Info

Title:
HuangQin; body temperature; IL-1β; PGE2; genuine herbs
文章编号:
1004-6852(2016)03-0008-03
作者:
谭超，安文蓉，刘娟，崔玉娇，朱青，谢瑞，于鹰△
山东中医药大学，山东 济南 250014
Author(s):
TAN Chao, AN Wenrong, LIU Juan, CUI Yujiao, ZHU Qing, XIE Rui, YU Ying△
Shandong University of Traditional Chinese Medicine, Jinan 250014, China
关键词:
大柴胡汤; 柴胡; 大黄; 抗炎; 镇痛
Keywords:
DaChaiHu Tang;  ChaiHu;  DaHuang;  anti-inflammatory;  analgesic
分类号:
R285
文献标志码:
A
摘要:
目的：探讨大柴胡汤中柴胡、大黄不同配比(5∶2，1∶1，2∶3)对小鼠抗炎镇痛作用的影响。方法：采用小鼠蛋清致肿胀法观察大柴胡汤中柴胡、大黄不同配比的抗炎作用，采用冰醋酸致小鼠扭体反应法观察大柴胡汤中柴胡、大黄不同配比的镇痛作用。结果：大柴胡汤中柴胡与大黄不同配比对冰醋酸致小鼠的扭体反应均有显著的抑制作用，并能对抗蛋清所引起的小鼠肿胀。结论：大柴胡汤中柴胡与大黄不同配比对小鼠抗炎镇痛作用的影响具有差异，其中，原方中柴胡与大黄用量比例为5∶2时的抗炎镇痛作用效果最佳。
Abstract:
Objective: To explore ChaiHu(Radix Bupleuri) and DaHuang (Rheum palmatum L.) in different proportions(5:2, 1:1, 2:3) influencing on anti-inflammatory and analgesic effects in mice. Methods: Anti-inflammatory effects of ChaiHu and DaHuang in different proportions in DaChaiHu Tang were observed by adopting mice albumen-induced swelling method, and analgesic effects of ChaiHu and DaHuang in different proportions in DaChaiHu Tang by glacial acetic acid-induced writhing test of the mice. Results: ChaiHu and DaHuang in different proportions in DaChaiHu Tang could inhibit glacial acetic acid-induced writhing test significantly, and could fight against albumen-induced swelling. Conclusion: The comparisons of ChaiHu and DaHuang in different proportions in DaChaiHu Tang here present notable differences, and the prescription shows the best anti-inflammatory and analgesic effects when the proportions of ChaiHu and DaHuang are 5:2.

相似文献/References:

[1]金国泰,李 博,王树荣△.柴胡解热的物质基础、药效及机制研究[J].西部中医药,2014,27(02):20.
　JIN Guotai,LI Bo,WANG Shurong.Research on the Mechanism, the Effects and Material Foundation of ChaiHu in Relieving Fever[J].Western Journal of Traditional Chinese Medicine,2014,27(03):20.
[2]刘博,王玉梅△,王涛,等.中西医结合治疗高脂血症性急性胰腺炎的临床研究[J].西部中医药,2014,27(05):96.
　LIU Bo,WANG Yumei,WANG Tao,et al.Clinical Study on Treating Hyperlipidemic Acute Pancreatitis by Integrative Medicine[J].Western Journal of Traditional Chinese Medicine,2014,27(03):96.
[3]黄海荣.大柴胡汤治疗窦型慢性根尖周炎40例[J].西部中医药,2019,32(08):70.
　HUANG Hairong.Dachaihu Decoction in the Treatment for 40 Cases of Sinus Chronic Periapical Periodontitis[J].Western Journal of Traditional Chinese Medicine,2019,32(03):70.
[4]潘宝峰,杨鲲,陈松,等.张仲景柴胡方方族组方规律研究[J].西部中医药,2022,35(01):93.[doi:10.12174/j.issn.2096-9600.2022.01.22]
　PAN Baofeng,YANG Kun,CHEN Song,et al.Study on the Formulation Law of Zhang Zhongjing’s Chaihu Formula Family[J].Western Journal of Traditional Chinese Medicine,2022,35(03):93.[doi:10.12174/j.issn.2096-9600.2022.01.22]
[5]张维芯,周青,戴国梁,等.基于SARS-CoV-2关键蛋白ACE2探索“葛根-柴胡”治疗COVID-19的潜在机制[J].西部中医药,2022,35(05):1.[doi:10.12174/j.issn.2096-9600.2022.05.01]
　ZHANG Weixin,ZHOU Qing,DAI Guoliang,et al.The Potential Mechanism of “Gegen-Chaihu” in the Treatment of COVID-19 Based on SARS-CoV-2 Target Protein ACE2[J].Western Journal of Traditional Chinese Medicine,2022,35(03):1.[doi:10.12174/j.issn.2096-9600.2022.05.01]
[6]吕婷婷,蓝绍航,李瑞暖,等.基于网络药理学方法分析柴胡配伍香附治疗癫痫的作用机制[J].西部中医药,2023,36(05):1.[doi:10.12174/j.issn.2096-9600.2023.05.01]
　LYU Tingting,LAN Shaohang,LI Ruinuan,et al.The Mechanism of Chaihu Combined with Xiangfu in the Treatment of Epilepsy Based on Network Pharmacology[J].Western Journal of Traditional Chinese Medicine,2023,36(03):1.[doi:10.12174/j.issn.2096-9600.2023.05.01]
[7]姚丽丽,王春虹,王婷婷.大柴胡汤联合短波紫外线与康复新液治疗小儿溃疡性口腔炎疗效观察[J].西部中医药,2024,37(10):120.[doi:10.12174/j.issn.2096-9600.2024.10.27]
　YAO Lili,WANG Chunhong,WANG Tingting.Clinical Observation on Dachaihu Tang Joined with Short-wave Ultraviolet C and Kangfuxin Liquid in the Treatment of Pediatric Ulcerative Stomatitis[J].Western Journal of Traditional Chinese Medicine,2024,37(03):120.[doi:10.12174/j.issn.2096-9600.2024.10.27]

备注/Memo

备注/Memo:
*基金项目：山东中医药大学大学生研究训练(SRT)计划项目(编号2014070)。作者简介：谭超(1993—)，女，在读硕士研究生。研究方向：内分泌系统疾病的诊治。△通讯作者：于鹰(1977—)，女，博士学位，讲师。研究方向：方剂学配伍理论。
更新日期/Last Update: 2016-03-15