[1]吴守义,李雪英,张邦能△.昆仑雪菊水提物对KKAy小鼠血清脂联素、抵抗素、血脂的影响[J].西部中医药,2017,30(10):12-15.
　WU Shouyi,LI Xueying,ZHANG Bangneng.The Effects of Aqueous Extract of KunLun Chrysanthemum on Serum Adiponectin, Resistin and Blood Lipid of KKAy Mice[J].Western Journal of Traditional Chinese Medicine,2017,30(10):12-15.
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昆仑雪菊水提物对KKAy小鼠血清脂联素、抵抗素、血脂的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年10期
页码:
12-15
栏目:
出版日期:
2017-10-15

文章信息/Info

Title:
The Effects of Aqueous Extract of KunLun Chrysanthemum on Serum Adiponectin, Resistin and Blood Lipid of KKAy Mice
文章编号:
1004-6852(2017)10-0012-04
作者:
吴守义1，李雪英2，张邦能3△
1 会宁县中医医院，甘肃 会宁 730799； 2 甘肃中医药大学； 3 甘肃省中医院
Author(s):
WU Shouyi1, LI Xueying2, ZHANG Bangneng3△
1 Huining County TCM Hospital, Huining 730799, China; 2 Gansu University of Traditional Chinese Medicine; 3 Gansu Provincial Hospital of Traditional Chinese Medicine
关键词:
昆仑雪菊; KKAy小鼠; 脂联素; 抵抗素; 血脂
Keywords:
KunLun Chrysanthemum;  KKAy mice;  adiponectin;  resistin;  blood lipid
分类号:
R285.5
文献标志码:
A
摘要:
目的：探讨昆仑雪菊水提物对KKAy小鼠血清脂联素、抵抗素、血脂的影响。方法：将SPF级7～8周龄雄性自发性2型糖尿病KKAy小鼠50只按体质量随机分为模型组(MC组)、昆仑雪菊低剂量组(KD组)、中剂量组(KZ组)、高剂量组(KG组)、吡格列酮组(B组)，正常对照组(NC组)选与KKAy小鼠同源的 C57BL/6J小鼠10只(NC组)。模型组和正常组给予0.9%氯化钠溶液，其余组给予对应浓度的药液灌胃。35天后取材测血清脂联素、抵抗素、血脂水平。结果：与模型组比较，昆仑雪菊低剂量组脂联素水平明显升高，差异有统计学意义(P＜0.05)；昆仑雪菊不同剂量组虽比模型组抵抗素水平降低，但差异无统计学意义(P＞0.05)；昆仑雪菊低剂量组高密度脂蛋白(HDL-C)水平提高，差异有统计学意义(P＜0.05)，而总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)水平无明显降低，差异无统计学意义(P＞0.05)。结论：昆仑雪菊水提物可能通过提升KKAy小鼠血清脂联素与HDL-C水平而发挥其改善胰岛素抵抗及脂代谢紊乱起作用。
Abstract:
Objective: To discuss the effects of aqueous extract of KunLun Chrysanthemum on adiponectin, resistin and blood lipid in the serum of KKAy mice. Methods: All 50 SPF male mice with idiopathic type two diabetes mellitus were randomized into the model group (MC group), low (KD group), moderate (KZ group) and high (KG group) dose groups of KunLun Chrysanthemum, Pioglitazone group (B group), ten C57BL/6J mice sharing the same source with KKAy mice were chosen as normal control group (NC group). The model group and the normal group were given 0.9% sodium chloride solution, and the other groups accepted intragastric administration of the corresponding concentrations of medicinal liquid. The levels of adiponectin, resistin and blood lipid in the serum were detected when the blood was drawn in 35 days. Results: Compared with the model group, the levels of adiponectin raised notably in the low dose group of KunLun Chrysanthemum, and the difference had statistical meaning (P＜0.05). The levels of resistin in different doses groups of KunLun Chrysanthemum were lower compared with the model group, while the difference had no statistical meaning (P＞0.05); low dose of KunLun Chrysanthemum could raise the levels of HDL-C, and the difference had statistical meaning (P＜0.05), while TC, TG and LDL-C showed no changes, and the difference presented no statistical meaning (P＞0.05). Conclusion: Aqueous extract of KunLun Chrysanthemum could improve insulin resistance and lipid disorders by raising the levels of adiponectin and HDL-C of KKAy mice.

相似文献/References:

[1]张邦能,舒畅,杜玫,等.昆仑雪菊水提物对2型糖尿病小鼠血糖及胰岛素水平的影响[J].西部中医药,2016,29(01):26.
　ZHANG Bangneng,SHU Chang,DU Mei,et al.Impact of Aqueous Extract from KunLun Snow Chrysanthemum on the Levels of Blood Glucose and Insulin of the Mice with Type Two Diabetes Mellitus[J].Western Journal of Traditional Chinese Medicine,2016,29(10):26.
[2]刘萍,段雅彬,陈红凯,等.昆仑雪菊中原花青素B2、绿原酸含量测定及对小鼠血糖的影响[J].西部中医药,2018,31(09):13.
　LIU Ping,DUAN Yabin,CHEN Hongkai,et al.Content Determination of Procyanidine B2 and Chlorogenic Acid Contained in Kunlun Chrysanthemum and the Influence on the Levels of Blood Glucose of the Mice[J].Western Journal of Traditional Chinese Medicine,2018,31(10):13.

备注/Memo

备注/Memo:
收稿日期：2016-10-24 *基金项目：2013年甘肃省自然科学基金项目(编号1308RJZA106)。 作者简介：吴守义(1966—)，男，主管检验技师。研究方向：藏药对2型胰岛素抵抗的研究。 △通讯作者：张邦能(1970—)，男，副主任检验师。研究方向：藏药对2型糖尿病胰岛素抵抗的研究。
更新日期/Last Update: 2017-10-15