[1]董林,雷宁波,邢涛,等.损伤胶囊对绝经后骨质疏松症患者疼痛、骨密度及骨代谢生化指标的影响[J].西部中医药,2017,30(11):8-11.
　DONG Lin,LEI Ningbo,XING Tao,et al.The Effects of Damage Capsules on the Pain, Bone Mineral Density and Biochemical Markers of Bone Metabolism of Postmenopausal Osteoporosis Patients[J].Western Journal of Traditional Chinese Medicine,2017,30(11):8-11.
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损伤胶囊对绝经后骨质疏松症患者疼痛、骨密度及骨代谢生化指标的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年11期
页码:
8-11
栏目:
出版日期:
2017-11-15

文章信息/Info

Title:
The Effects of Damage Capsules on the Pain, Bone Mineral Density and Biochemical Markers of Bone Metabolism of Postmenopausal Osteoporosis Patients
文章编号:
1004-6852(2017)11-0008-04
作者:
董林1，雷宁波1，邢涛1，赵军1，王志勇1，彭冉东2
1 甘肃省中医院，甘肃 兰州 730050； 2 甘肃中医药大学
Author(s):
DONG Lin1, LEI Ningbo1, XING Tao1, ZHAO Jun1, WANG Zhiyong1, PENG Randong2
1 Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China; 2 Gansu University of Traditional Chinese Medicine
关键词:
骨质疏松症; 绝经后妇女; 钙尔奇; 损伤胶囊
Keywords:
osteoporosis;  postmenopausal women;  Caltrate;  damage capsules
分类号:
R259
摘要:
目的：观察损伤胶囊联合钙尔奇D治疗骨质疏松症的临床疗效。方法：将绝经后骨质疏松妇女随机分为2组，观察组66例口服损伤胶囊及钙尔奇D；对照组68例口服钙尔奇D，对2组患者进行不少于1年的随访后采用双能X线吸收法（DXA)检测治疗前后2组患者腰椎侧位(L2)、尺桡骨远端、股骨粗隆部、总体骨密度（BMD)以及骨代谢生化（血清钙、血磷及血碱性磷酸酶)指标；采用视觉模拟疼痛评分(visual analogue scale，VAS)法对患者腰背部疼痛进行评估；行X线检查2组患者骨折发生率。结果：2组患者治疗后3月腰背部疼痛缓解，对照组治疗后6月及末次随访时VAS评分指数高于观察组（P＜0.05)。末次随访时2组L2、尺桡骨远端、股骨粗隆部、总体骨密度均有提高，但观察组优于对照组，差异有统计学意义（P＜0.05)。治疗前2组患者血清钙、血磷及血碱性磷酸酶比较差异无统计学意义（P＞0.05)，治疗后末次随访时血清钙、血磷比较差异无统计学意义（P＞0.05)，观察组较对照组血碱性磷酸酶下降明显，差异有统计学意义(P＜0.05)。结论：损伤胶囊联合钙尔奇D可有效减轻因骨质疏松进行性加重而导致的腰背痛，能改善骨代谢生化标记物，提高骨密度，有效降低早期骨折的发生率。
Abstract:
Objective: To observe curative effects of damage capsules combined with Caltrate D in the treatment for osteoporosis. Methods: The postmenopausal women with osteoporosis were randomized into two groups, 66 cases in the observation group took damage capsules combined with Caltrate D orally, and 68 cases in the control group Caltrate D, all the patients were followed up not less than one year, biochemical markers of bone metabolism (serum calcium, serum inorganic phosphorus and serum alkaline phosphatase), bone mineral density (BMD), trochanteric portion of femur, distal ulnar and radius and L2 of the patients in both groups were detected before and after treating by adopting dual energy X-ray absorptiometry (DXA); back pain of the patients were assessed by using VAS; bone fracture incidence of the patients in both groups were examined by performing X ray. Results: Back pain relieved in both groups in three months after treating, while VAS scales of the control group were higher than these of the observation group in six months after treating and the last follow-up (P＜0.05). In the last follow-up, BMD, trochanteric portion of femur, distal ulnar and radius and L2 of the patients in both groups raised, but the observation group was superior to the control group, and the difference had statistical meaning (P＜0.05). The difference had no statistical meaning in the comparisons of serum calcium, serum inorganic phosphorus and serum alkaline phosphatase between both groups before treating (P＞0.05), and the difference had no statistical meaning in the comparisons of serum calcium and serum inorganic phosphorus in the last follow-up after treating (P＞0.05), the decrease of serum alkaline phosphatase in the observation group was more notable compared with the control group, and the difference showed statistical meaning (P＜0.05). Conclusion: Damage capsules combined with Caltrate D could effectively alleviate back pain caused by progressive exacerbation of osteoporosis; the therapy could improve biochemical markers of bone metabolism, raise BMD and effectively reduce the incidence of early bone fracture.

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备注/Memo

备注/Memo:
收稿日期：2017-03-04 *基金项目：甘肃省中医药管理局项目(编号GZK-2014-10)。 作者简介：董林(1965—)，男，硕士研究生导师，主任医师，甘肃省名中医。研究方向：类风湿性关节炎的中西医结合治疗。
更新日期/Last Update: 2017-11-15