[1]苏成程,唐艳芬,章匀,等.降气止咳免煎颗粒对CVA疗效及对TNF-γ、IL-4和气道反应性的影响[J].西部中医药,2017,30(12):48-50.
　SU Chengcheng,TANG Yanfen,ZHANG Yun,et al.Clinical Effects of JiangQi ZhiKe Granules in Treating CVA and Its Influence on TNF-γ, IL-4 and Airway Reactivity[J].Western Journal of Traditional Chinese Medicine,2017,30(12):48-50.
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降气止咳免煎颗粒对CVA疗效及对TNF-γ、IL-4和气道反应性的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年12期
页码:
48-50
栏目:
出版日期:
2017-12-15

文章信息/Info

Title:
Clinical Effects of JiangQi ZhiKe Granules in Treating CVA and Its Influence on TNF-γ, IL-4 and Airway Reactivity
文章编号:
1004-6852(2017)12-0048-03
作者:
苏成程，唐艳芬，章匀，尤菊松
南通市中医院呼吸内科，江苏 南通 226001
Author(s):
SU Chengcheng, TANG Yanfen, ZHANG Yun, YOU Jusong
Department of Respiratory Medicine, Nantong Municipality TCM Hospital, Nantong 226001, China
关键词:
咳嗽变异性哮喘; 降气止咳免煎颗粒; TNF-γ; IL-4; 气道反应性
Keywords:
cough variant asthma;  JiangQi ZhiKegranules;  TNF-γ;  IL-4;  airway reactivity
分类号:
R562.2+5
文献标志码:
B
摘要:
目的：观察降气止咳免煎颗粒治疗咳嗽变异性哮喘(cough variant asthma，CVA)的疗效及对肿瘤坏死因子γ(TNF-γ)和白介素4（IL-4）及气道反应性的影响。方法：将60例患者随机分为观察组与对照组，每组各30例，分别给予降气止咳免煎颗粒与苏黄止咳胶囊口服，疗程4周。观察2组治疗前后证候积分及血清TNF-γ、IL-4及气道反应性的变化并进行对比分析。结果：证候总积分治疗后组间比较差异有统计学意义(P＜0.05)。总有效率观察组为96.67%，对照组为93.33%，2组比较差异无统计学意义(P＞0.05)。TNF-γ和IL-4治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后组间比较，差异有统计学意义(P＜0.05)。气道反应性指标(PD20FEV1)治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后组间比较，差异有统计学意义(P＜0.05)。2组在治疗过程中均未发现明显毒副作用(P＜0.05)。结论：降气止咳免煎颗粒对CVA证候疗效与苏黄止咳胶囊相当，且安全性较好，能降低血清IL-4水平，提高血清TNF-γ水平，纠正Thl/Th2细胞因子平衡失调，有效降低气道反应性。
Abstract:
Objective: To observe JiangQi ZhiKe granules in treating cough variant asthma (CVA) and its influence on TNF-γ, IL-4 and airway reactivity (AR). Methods: Sixty patients were randomized into the observation group and the control group, 30 cases each group, both groups took JiangQi ZhiKe granules and SuHuang ZhiKe capsules orally, the course was four weeks. The changes of TNF-γ, IL-4, AR and syndrome scales of both groups were observed, compared and analyzed. Results: The difference had statistical meaning in the comparisons of total scales of the syndrome between both groups after treating (P＜0.05). Total effective rate of the observation group was 96.67%, higher than 93.33% of the control group, and the difference had no statistical meaning (P＞0.05). The difference had statistical meaning in the comparisons of TNF-γ and IL-4 within both groups before and after treating (P＜0.05); the difference showed statistical meaning in the comparisons between both groups after treating (P＜0.05). The difference had statistical meaning in the comparisons of PD20FEV1 before and after treating within two groups (P＜0.05); the difference had statistical meaning in the comparisons between both groups after treating (P＜0.05).Obvious toxic and adverse reaction happened during therapeutic courses in both groups (P＜0.05). Conclusion:JiangQi ZhiKegranules are equivalent to SuHuang ZhiKe capsules in treating CVA, and the therapy shows high safety, it could lower the level of IL-4, raise the level of TNF-γ, correct the imbalance of Th1/Th2 cytokines and effectively relieve airway reactivity.

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备注/Memo

备注/Memo:
收稿日期：2017-05-26 *基金项目：南通市卫生局2014年青年医学人才科研基金项目(编号WQ2014051)。 作者简介：苏成程(1979—)，男，硕士学位，主治医师。研究方向：中医药防治呼吸系统临床疾病。
更新日期/Last Update: 2017-12-15