[1]杨立静.凉血解毒止痛方对急性肛裂中医证候积分、hs-CRP、IL-6及疗效的影响[J].西部中医药,2017,30(12):51-54.
　YANG Lijing.Clinical Effects of Blood-cooling Detoxifying Pain-relieving Prescriptions in Treating Acute Anal Fissure and Its Effects on TCM Syndrome Scales, the Expressions of hs-CRP and IL-6[J].Western Journal of Traditional Chinese Medicine,2017,30(12):51-54.
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凉血解毒止痛方对急性肛裂中医证候积分、hs-CRP、IL-6及疗效的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年12期
页码:
51-54
栏目:
出版日期:
2017-12-15

文章信息/Info

Title:
Clinical Effects of Blood-cooling Detoxifying Pain-relieving Prescriptions in Treating Acute Anal Fissure and Its Effects on TCM Syndrome Scales, the Expressions of hs-CRP and IL-6
文章编号:
1004-6852(2017)12-0051-04
作者:
杨立静
唐山市中医医院，河北 唐山 063000
Author(s):
YANG Lijing
Tangshan Municipality TCM Hospital, Tangshan 063000, China
关键词:
肛裂; 急性; 凉血解毒止痛方; 中医证候积分; 生活质量; 血清超敏C反应蛋白; 白介素6
Keywords:
anal fissure;  acute;  blood-cooling detoxifying pain-relieving prescriptions;  TCM syndrome scales;  quality of life;  hs-CRP;  IL-6
分类号:
R657.1+4
文献标志码:
B
摘要:
目的：探讨凉血解毒止痛方治疗急性肛裂的临床疗效及对中医证候积分和血清超敏C反应蛋白(hs-CRP)和白介素6(IL-6)表达的影响。方法：将94例患者随机分为对照组和观察组，每组各47例。对照组给予西医常规治疗，观察组在对照组治疗的基础上给予凉血解毒止痛方治疗，10天后观察2组临床疗效，疼痛、水肿、便秘、出血、脓肿中医证候积分和生活质量，采用Elisa法检测hs-CRP和IL-6表达水平。结果：总有效率观察组95.74%，对照组为78.72%，2组比较差异有统计学意义(P＜0.05)。疼痛、水肿、便秘、出血、脓肿中医证候积分治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后组间比较，差异也有统计学意义(P＜0.05)。躯体功能、认知功能、情绪功能、角色功能、社会功能等生活质量评治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后组间比较，差异也有统计学意义(P＜0.05)。血清hs-CRP和IL-6表达水平治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后组间比较，差异也有统计学意义(P＜0.05)。结论：凉血解毒止痛方治疗急性肛裂具有较好的临床疗效，可降低中医证候积分，提高生活质量，减轻炎症反应。
Abstract:
Objective: To discuss clinical effects of blood-cooling detoxifying pain-relieving prescriptions in the treatment for acute anal fissure and its effects on TCM syndrome scales, the expressions of hs-CRP and IL-6. Methods: All 94 patients were randomized into the control group and the observation group, 47 cases each group. The control group accepted routine treatment of western medicine, and the observation group took blood-cooling detoxifying pain-relieving prescriptions on the foundation of the therapy the control group received, clinical effects, TCM syndrome scales such as pain, edema, constipation, bleeding and abscess, and quality of life of both groups were observed in ten days, the expressions of hs-CRP and IL-6 were detected by using Elisa method. Results: Total effective rate of the observation group was 95.74%, higher than 78.72% of the control group, and the difference had statistical meaning (P＜0.05). The difference had statistical meaning in the comparisons of TCM syndrome scales such as pain, edema, constipation, bleeding and abscess before and after treating within the groups (P＜0.05); and the difference showed statistical meaning in the comparisons between both groups after treating (P＜0.05). The difference showed statistical meaning in the comparisons of the scales of quality of life including somatic function, cognitive function, emotional function, role function, social function and others within the groups before and after treating (P＜0.05); the difference had statistical meaning in the comparisons between both groups after treating (P＜0.05). The difference presented statistical meaning in the comparisons of the expressions of hs-CRP and IL-6 within the groups before and after treating (P＜0.05); the difference had statistical meaning in the comparisons between both groups after treating (P＜0.05). Conclusion: Blood-cooling detoxifying pain-relieving prescriptions are effective in the treatment for acute anal fissure, which could lower TCM syndrome scales, improve quality of life and relieve inflammatory reaction.

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备注/Memo

备注/Memo:
收稿日期：2017-05-28 *基金项目：河北省自然科学基金面上项目(编号0131674)；河北省中医药管理局科研指导计划项目(编号20131227)。 作者简介：杨立静(1980—)，女，主治医师。研究方向：肛肠疾病。
更新日期/Last Update: 2017-12-15