[1]邵建兵,汪燕,王加林.麝香保心丸治疗冠心病急性心肌梗死44例[J].西部中医药,2017,30(12):61-64.
　SHAO Jianbin,WANG Yan,WANG Jialin.SheXiang BaoXin Pills in Treating 44 Cases of Acute Myocardial Infarction of Coronary Heart Disease[J].Western Journal of Traditional Chinese Medicine,2017,30(12):61-64.
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麝香保心丸治疗冠心病急性心肌梗死44例
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年12期
页码:
61-64
栏目:
出版日期:
2017-12-15

文章信息/Info

Title:
SheXiang BaoXin Pills in Treating 44 Cases of Acute Myocardial Infarction of Coronary Heart Disease
文章编号:
1004-6852(2017)12-0061-04
作者:
邵建兵，汪燕，王加林
如皋市人民医院，江苏 如皋 226500
Author(s):
SHAO Jianbin, WANG Yan, WANG Jialin
Rugao Municipality People′s Hospital, Rugao 226500, China
关键词:
心肌梗死; 急性; 冠心病; 麝香保心丸; 心功能; 黏附分子
Keywords:
myocardial infarction;  acute;  coronary heart disease;  SheXiang BaoXin pills;  heart function;  adhesion molecule
分类号:
R542.2+2
文献标志码:
B
摘要:
目的：观察麝香保心丸辅助治疗对冠心病（CHD)急性心肌梗死（AMI)患者心功能的影响及其黏附分子层面作用机制。方法：将88例患者随机分为观察组、对照组各44例。对照组予以AMI常规西医治疗，观察组在对照组基础上加用麝香保心丸治疗，疗程4周。比较2组治疗前后中医临床证候评分、心功能相关指标、血清细胞间黏附分子1（ICAM-1)、血管细胞黏附分子1（VCAM-1)水平及不良事件（MACE)发生率。结果：总有效率观察组为88.64%，对照组为72.73%，2组比较差异有统计学意义(P＜0.05)。中医证候积分治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后2组组间比较，差异也有统计学意义(P＜0.05)。左室射血分数（LVEF)、左室舒张末期容积（LVEDV)、左室收缩末期容积（LVESV)治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后2组组间比较，差异也有统计学意义(P＜0.05)。肌酸激酶同工酶（CK-MB）、脑钠肽（cTnⅠ）及肌红蛋白I（BNP）水平治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后2组组间比较，差异也有统计学意义(P＜0.05)。血清ICAM-1、VCAM-1水平治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后2组组间比较，差异也有统计学意义(P＜0.05)。随访3个月，MACE发生率观察组为4.55%，对照组为15.91%，2组比较差异有统计学意义(P＜0.05)。结论：麝香保心丸辅助治疗CHD后AMI疗效确切，其作用机制可能是下调血清ICAM-1、VCAM-1而抑制炎性反应所致心肌损伤，改善心功能。
Abstract:
Objective: To survey the effects of SheXiang BaoXin pills as adjunctive therapy (AT) on heart function of the patients with acute myocardial infarction (AMI) of coronary heart disease (CHD) and the mechanism in adhesion molecule layer. Methods: All 88 patients were randomized into the observation group and the control group equally. The control group accepted AMI conventional therapy of western medicine, and the observation group took SheXiang BaoXin pills on the foundation of the treatment the control group received, the course was four weeks. The incidence of major adverse cardiac events (MACE), the levels of serum intercellular adhesion molecule-1(ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), the related indexes of heart function, and TCM clinical syndrome scales of both groups were compared before and after treating. Results: Total effective rate of the observation group was 88.64%, higher than 72.73% of the control group, and the difference had statistical meaning (P＜0.05). The difference was statistically significant in the comparisons of TCM syndrome scales before and after treating within two groups (P＜0.05), there was a significant difference in the comparison between both groups after treating (P＜0.05). The difference was statistically significant in the comparisons of LVEF, LVEDV and LVESV within two groups before and after treating (P＜0.05), there was a significant difference in the comparison between both groups after treating(P＜0.05). The difference wasstatistically significant in the comparisons of the levels of CK-MB, cTn Ⅰ and BNP before and after treating within two groups (P＜0.05), there was significant difference in the comparisons between both groups after treating (P＜0.05). The difference was a statistically significant in the comparisons of the levels of ICAM-1 and VCAM-1 before and after treating within two groups (P＜0.05), there was a significant difference in the comparisons between both groups after treating (P＜0.05). After following up for three months, the incidence of MACE in the observation group was 4.55%, lower than 15.91% of the control group, and there was significant difference between both groups (P＜0.05).Conclusion: SheXiang BaoXin pills as AT for AMI of CHD could obtain definite effects, and its mechanism might be related to myocardial damage induced by inhibiting inflammatory reaction through down regulation the levels of ICAM-1 and VCAM-1, as well as to improve heart function.

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备注/Memo

备注/Memo:
收稿日期：2017-06-06 作者简介：邵建兵(1971—)，男，副主任药师。研究方向：药理药剂临床。
更新日期/Last Update: 2017-12-15