[1]张中华,牟倩倩,张亚会.不同厂家当归配方颗粒与当归饮片的质量分析研究[J].西部中医药,2018,31(03):30-32.
　ZHANG Zhonghua,MOU Qianqian,ZHANG Yahui.Study on Quality Analysis of DangGui Crude Slices and DangGui Dispensing Granules in Different Factories[J].Western Journal of Traditional Chinese Medicine,2018,31(03):30-32.
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不同厂家当归配方颗粒与当归饮片的质量分析研究()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年03期
页码:
30-32
栏目:
出版日期:
2018-03-15

文章信息/Info

Title:
Study on Quality Analysis of DangGui Crude Slices and DangGui Dispensing Granules in Different Factories
文章编号:
1004-6852(2018)03-0030-03
作者:
张中华，牟倩倩，张亚会
甘肃省中医院，甘肃 兰州 730050
Author(s):
ZHANG Zhonghua, MOU Qianqian, ZHANG Yahui
Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
关键词:
当归配方颗粒; 阿魏酸; 质量分析; 高效液相色谱
Keywords:
DangGui dispensing granules;  ferulic acid;  quality analysis;  HPLC
分类号:
R284
摘要:
目的：采用高效液相色谱法测定当归饮片及A、B不同厂家生产的当归配方颗粒中阿魏酸的含量，比较三者阿魏酸含量的差异。方法：以Waters Symmetry Shield RP-C18(4.6 mm×250 mm，5 μm)为色谱柱，甲醇-0.5%醋酸溶液(20∶80)为流动相，流速为1.0 mL/min，检测波长为320 nm。测定当归饮片及A、B不同厂家当归配方颗粒中阿魏酸的含量。结果：阿魏酸在 0.0138～0.0690 mg/mL(r=0.999，n=6)的范围内浓度与峰积分面积线性关系良好，平均回收率为97.72%，RSD=1.06%。结论：当归饮片中阿魏酸的含量符合药典规定；A、B不同厂家配方颗粒中阿魏酸含量均低于当归饮片中阿魏酸含量，且A、B不同厂家的配方颗粒中阿魏酸含量也存在较大差异。
Abstract:
Objective: To detect the contents of ferulic acid in Danggui crude slices and DangGui dispensing granules from the manufacture A and B by HPLC, and compare the difference among these three. Methods: The contents of ferulic acid in Danggui crude slices and DangGui dispensing granules from the manufacture A and B were detected by using Waters Symmetry Shield RP-C18 (4.6 mm×250 mm, 5 μm) as chromatographic column, methanol-0.5% acetum (20:80) as the mobile phase, flow rate: 1.0mL/min, detection wavelength: 320 nm. Results: The concentrations and peak integral area showed good linear relationship in the concentrations from 0.013 8 to 0.069 0 mg/mL(r=0.999, n=6), average recovery rate was 97.72% respectively, RSD=1.06%. Conclusion: The contents of ferulic acid in DangGui crude slices meet the standard of pharmacopoeia; the contents of ferulic acid in dispensing granules from the manufacture A and B are lower than these in DangGui crude slices, and there is the bigger difference existed in the contents of ferulic acid contained in dispensing granules from the manufacture A and B.

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备注/Memo

备注/Memo:
收稿日期：2016-11-08 作者简介：张中华(1984—)，男，主管中药师。研究方向：中药调剂与监测的规范化研究。
更新日期/Last Update: 2018-03-15