[1]施星臣,孙仕华,吕黎,等.复方抗骨质增生缓释片治疗膝关节骨性关节炎的对照研究[J].西部中医药,2018,31(11):7-10.
　SHI Xingchen,SUN Shihua,LYU Li,et al.Case-control Study on Treating Knee Osteoarthritis by Compound Anti-hyperosteogeny Sustained-release Tablets[J].Western Journal of Traditional Chinese Medicine,2018,31(11):7-10.
点击复制

复方抗骨质增生缓释片治疗膝关节骨性关节炎的对照研究()
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年11期
页码:
7-10
栏目:
出版日期:
2018-11-15

文章信息/Info

Title:
Case-control Study on Treating Knee Osteoarthritis by Compound Anti-hyperosteogeny Sustained-release Tablets
文章编号:
1004-6852(2018)11-0007-04
作者:
施星臣1，孙仕华1，吕黎2，李晓强3，王经韬1，许筠1，余利军4△
1 兰州市第二人民医院，甘肃 兰州 730046； 2 甘肃中医药大学； 3 兰州大学第二医院； 4 甘肃省人民医院
Author(s):
SHI Xingchen1, SUN Shihua1, LYU Li2, LI Xiaoqiang3, WANG Jingtao1, XU Jun1, YU Lijun4△
1 The Second People′s Hospital of Lanzhou City, Lanzhou 730046, China; 2 Gansu University of Chinese Medicine; 3 Lanzhou University Second Hospital; 4 Gansu Provincial Hospital
关键词:
骨质增生; 骨性关节炎; 膝; 炎性因子; 复方抗骨质增生缓释片
Keywords:
hyperosteogeny;  knee osteoarthritis;  inflammatory factors;  compound anti-hyperosteogeny sustained-release tablets
分类号:
R684.3
文献标志码:
A
摘要:
目的：观察复方抗骨质增生缓释片治疗膝关节骨性关节炎的临床疗效。方法：将膝关节骨性关节炎患者140例按随机数字表法分为试验组和对照组各70例。对照组给予超短波理疗机治疗，试验组口服复方抗骨质增生缓释片治疗。4周为1个疗程，2组均治疗4个疗程后观察并记录患者Lesquesne评分以及基质金属蛋白酶9（MMP-9）、肿瘤坏死因子α（TNF-α）、白细胞介素1（IL-1）、白细胞介素6（IL-6）炎性介质的水平。结果：1个疗程后，2组患者的休息痛、运动痛、压痛、肿胀、晨僵及行走能力均得到不同程度改善，Lesquesne指数呈下降趋势；4个疗程后治疗组有效率为75.7%（53/70），高于对照组的65.7%(46/70)，差异有统计学意义（P＜0.05）。Lesquesne指数2组比较差异有统计学意义（P＜0.05），但休息痛、肿胀、晨僵2组比较差异无统计学意义（P＞0.05）。2组患者TNF-α，MMP-9、IL-1、IL-6水平1个疗程后呈下降趋势，4个疗程后2组比较差异有统计学意义（P＜0.05）。结论：复方抗骨质增生缓释片治疗膝关节骨性关节炎疗效优于超短波理疗，其作用机制可能与抗炎性因子的表达有关。
Abstract:
Objective: To explore clinical effects of compound anti-hyperosteogeny sustained-release tablets in treating knee osteoarthritis (KOA). Methods: All 140 KOA patients were randomized into the experiment group and the control group according to random number table method, 70 cases each group. The patients in the control group were treated by ultra-short wave physical therapy, and the ones in the experiment group took compound anti-hyperosteogeny sustained-release tablets orally. Four weeks were one course, the levels of inflammatory factors such as IL-6, IL-1, TNF-α, MMP-9 and Lesquesne scores of the patients were observed and recorded after they were treating for four courses. Results: After one course, rest pain, motion pain, tenderness, swelling, morning stiffness and walking ability of the patients in both groups were group improved to different degrees, Lesquesne index showed the decreasing tendency; by the end of the forth course, the effective rate of the treatment group was 75.7% (53/70), it had statistical meaning when compared with 65.7%(46/70) the control group(P＜0.05). The difference had statistical meaning in the comparisons of Lesquesne indexes between both groups(P＜0.05), while the difference had no statistical meaning in the comparisons of rest pain,swelling and morning stiffiness between both groups(P＞0.05).After one course, the level of TNF-α, MMP-9, IL-1 and IL-6 presented the tendency of lowering in the patients of the experiment group; by the end of the forth course, the difference was statistically significant when motion pain, tenderness and walking ability of the experiment group were compared with these of the control group(P＜0.05).Conclusion: The mechanism of compound anti-hyperosteogeny sustained-release tablets in treating KOA might be fighting against the expressions of inflammatory factors.

相似文献/References:

[1]李兴勇,徐霞,麻虎,等.中医药治疗膝关节骨性关节炎的现状[J].西部中医药,2013,26(12):144.
　LI Xingyong,XU Xia,MA Hu,et al.Progress of Treatment for Knee Osteoarthritis by TCM[J].Western Journal of Traditional Chinese Medicine,2013,26(11):144.
[2]李春娥,董建文,王文波.膝关节骨性关节炎熏洗方用药规律文献研究[J].西部中医药,2015,28(03):97.
[3]王想福,石瑞芳,武纪玲,等.玻璃酸钠单独使用与联合解毒消瘀膏治疗膝骨性关节炎疗效观察[J].西部中医药,2015,28(03):118.
[4]周天恒.针灸治疗膝骨性关节炎临床观察[J].西部中医药,2015,28(04):123.
[5]陆金金,欧阳八四.电针与温针灸治疗瘀血阻滞型膝骨关节炎的疗效比较[J].西部中医药,2014,27(04):119.
　LU Jinjin,OUYANG Basi.Comparison of Clinical Effects between Acusector and Warm Needling Moxibustion in Treating Knee Osteoarthritis of Blood Stasis Obstruction Pattern[J].Western Journal of Traditional Chinese Medicine,2014,27(11):119.
[6]田雪梅,张丽君,柳树英.中医外治法辨证治疗膝骨性关节炎120例[J].西部中医药,2012,25(10):95.
　TIAN Xue-mei,ZHANG Li-jun,LIU Shu-ying.Syndrome Differentiation of TCM External Treatment for 120 Cases of Knee Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2012,25(11):95.
[7]赵道洲,郑恒恒.手法配合陇中Ⅰ号汽雾透皮疗法治疗膝骨性关节炎的临床研究*[J].西部中医药,2013,26(04):36.
　ZHAO Daozhou,ZHENG Hengheng.Clinical Study on Manipulation and Gansu Mist Transdermal Therapy No.1 in Treating Knee Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2013,26(11):36.
[8]郝峰.中药提速透化结合点穴按摩治疗膝骨性关节炎90例[J].西部中医药,2017,30(10):105.
　HAO Feng.Herbs Accelerating Permeabilization Combined with Acupoint Massage in Treating 90 Cases of Knee Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2017,30(11):105.
[9]李宁,李应福,谢兴文,等.兰州地区膝关节骨性关节炎的中医证候分布特点[J].西部中医药,2016,29(02):95.
　LI Ning,LI Yingfu,XIE Xingwen,et al.Distribution Features of TCM Syndromes of Knee Osteoarthritis in Lanzhou City[J].Western Journal of Traditional Chinese Medicine,2016,29(11):95.
[10]姚兴璋,李兴勇,李喜香,等.骨痹止痛液对兔膝骨性关节炎软骨中相关因子表达影响的研究[J].西部中医药,2016,29(04):29.
　YAO Xingzhang,LI Xingyong,LI Xixiang,et al.Study on the Influence of GuBi ZhiTong Liquid on Cartilage-related Factors Expressions of the Rabbits with Knee Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2016,29(11):29.

备注/Memo

备注/Memo:
收稿日期：2018-01-26 *基金项目：甘肃省青年科技基金计划(编号1506RJYA315)。 作者简介：施星臣(1980—)，男，副主任医师。研究方向：骨关节疾病的诊治。 △通讯作者：余利军(1968—)，女，副主任药师。研究方向：医院药学与药物制剂。
更新日期/Last Update: 2018-11-15